Protein Information

Name CA1
Synonyms CA IX; CA1; Carbonic anhydrase I; CA2; CAII; Carbonic anhydrase II; Carbonic dehydratase; Carbonic anhydrase III…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
17284575 Sener A, Jijakli H, Zahedi Asl S, Courtois P, Yates AP, Meuris S, Best LC, Malaisse WJ: Possible role of carbonic anhydrase in rat pancreatic islets: enzymatic, secretory, metabolic, ionic, and electrical aspects. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1624-30. Epub 2007 Feb 6.

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15895688 Demir Y, Nadaroglu H, Demir N: Purification and characterization of carbonic anhydrase from bovine stomach and effects of some known inhibitors on enzyme activity. J Enzyme Inhib Med Chem. 2005 Feb;20(1):75-80.

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17970284 Demir Y, Nadaroglu H, Demir N: Purification and some properties of carbonic anhydrase from Elephas trogontherii (Steppe elephant) bone. Indian J Biochem Biophys. 2007 Aug;44(4):252-6.

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15082229 Cho S, Liu D, Fairman D, Li P, Jenkins L, McGonigle P, Wood A: Spatiotemporal evidence of apoptosis-mediated ischemic injury in organotypic hippocampal slice cultures. Neurochem Int. 2004 Jul;45(1):117-27.

Neuronal death was first evident in the CA1 region 24 h after the injury as assessed by propidium iodide (PI) labeling, and continued to extend to the CA3/4 region up to 72 h.
In order to ascertain the existence of the synaptic pool of glutamate, sister cultures were treated with sodium azide.
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16412262 Wang ZJ, Li GM, Tang WL, Yin M: Neuroprotective effects of stearic acid against toxicity of oxygen/glucose deprivation or glutamate on rat cortical or hippocampal slices. Acta Pharmacol Sin. 2006 Feb;27(2):145-50.

AIM: To observe the effects of stearic acid, a long-chain saturated fatty acid consisting of 18 carbon atoms, on brain (cortical or hippocampal) slices insulted by oxygen-glucose deprivation (OGD), glutamate or sodium azide (NaN3) in vitro.
METHODS: The activities of hippocampal slices were monitored by population spikes recorded in the CA1 region.
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14991459 Weinstock M, Shoham S: Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity. J Neural Transm. 2004 Mar;111(3):347-66. Epub 2003 Dec 12.

Three models are described in rats which attempt to mimic morphological and behavioural pathology of Alzheimer's dementia; intracerebroventricular injection of streptozotocin (STZ), permanent bilateral carotid artery occlusion (2VO) and brain mitochondrial cytochrome oxidase inhibition by sodium azide.
STZ causes microglial activation and specific damage to myelinated tracts in the fornix through generation of oxidative stress, thereby disrupting connections between the septum and hippocampus. 2VO results in damage to myelin and CA1 cells in hippocampus and in abnormal processing of APP to beta-amyloid.
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