| Name | ATPases |
|---|---|
| Synonyms | (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9726993 | Vasilyeva E, Forgac M: Interaction of the clathrin-coated vesicle V-ATPase with ADP and sodium azide. J Biol Chem. 1998 Sep 11;273(37):23823-9. We have further investigated the effect of sodium azide, an inhibitor of the F-ATPases that has been shown to stabilize an inactive complex between ADP and the F1-F0-ATP synthase (F-ATPase). |
2(0,0,0,2) | Details |
| 9888269 | Yaktubay N, Ogulener N, Onder S, Baysal F: Possible stimulation of Na+-K+-ATPase by NO produced from by ultraviolet light in mouse gastric fundal strip. Gen Pharmacol. 1999 Jan;32(1):159-62. In the present study, we investigated the roles of Na+-K+-ATPase and extracellular Na+ or Ca2+ ions in ultraviolet (UV) light-induced photorelaxation of methacholine-contracted mouse isolated gastric fundus in the presence of NaNO2 (50 microM). 2. Metabolic inhibitors, sodium azide (10-100 microM), 2,4-dinitrophenol (100 microM to 1 mM) and (100 microM to 1 mM) significantly reduced photorelaxation. 4. |
2(0,0,0,2) | Details |
| 8687417 | Docampo R, Vanderheyden NM, Shaw MM, Durant PJ, Bartlett MS, Smith JW, McLaughlin GL: An H (+)-ATPase regulates cytoplasmic pH in Pneumocystis carinii trophozoites. Biochem J. 1996 Jun 1;316 ( Pt 2):681-4. In contrast, the general inhibitors of ATPases, N-ethylmaleimide (1 mM), and dicyclohexylcarbodi-imide (100 microM), and the inhibitor of yeast H (+)-ATPase, diethylstilbestrol (12.5-100 microM), decreased pHi, while the K+/H (+)-ATPase inhibitor (50-400 microM), and the vacuolar-type H (+)-ATPase inhibitor bafilomycin A1 (1-5 microM) only produced a dose-dependent acidification of the cells when used at high concentrations. In addition, steady-state pHi depended on the availability of cellular ATP, since it was decreased by the ATP synthase inhibitors oligomycin (1 microgram/ml) and sodium azide (1 mM), and by the uncoupler of oxidative phosphorylation carbonyl p-trifluorophenylhydrazone (1 microM), agents that were able to deplete significantly the intracellular ATP levels. |
1(0,0,0,1) | Details |
| 10231536 | Smith TM, Lewis Carl SA, Kirley TL: Mutagenesis of two conserved residues of the E-type ATPases: inactivation and conversion of an ecto-apyrase to an ecto-NTPase. Biochemistry. 1999 May 4;38(18):5849-57. |
2(0,0,0,2) | Details |
| 11325562 | Ju R, Mao Y, Glick MJ, Muller MT, Snyder RD: Catalytic inhibition of DNA topoisomerase IIalpha by sodium azide. . Toxicol Lett. 2001 Apr 30;121(2):119-26. Azide interferes with mitochondrial production of ATP and is also known to inhibit cellular ATPases. |
1(0,0,0,1) | Details |
| 19226326 | Hahn J, Kramer N, Briley K Jr, Dubnau D: McsA and B mediate the delocalization of competence proteins from the cell poles of Bacillus subtilis. Mol Microbiol. 2009 Apr;72(1):202-15. Epub 2009 Feb 17. We show that localization most likely occurs by a diffusion-capture mechanism, not requiring metabolic energy, whereas delocalization is prevented in the presence of sodium azide. We further show that the protein kinase proteins McsA and McsB are needed for delocalization, as are ClpP and either of the AAA (+) (ATPases associated with a variety of cellular activities) proteins ClpC or ClpE. |
1(0,0,0,1) | Details |
| 15284222 | Kaasik A, Joubert F, Ventura-Clapier R, Veksler V: A novel mechanism of regulation of cardiac contractility by mitochondrial functional state. FASEB J. 2004 Aug;18(11):1219-27. It is generally considered that mitochondria regulate cardiac cell contractility by providing ATP for cellular ATPases and by participating in Ca2+ homeostasis. |
1(0,0,0,1) | Details |
| 11278748 | Kawasaki-Nishi S, Nishi T, Forgac M: Yeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation. J Biol Chem. 2001 May 25;276(21):17941-8. Epub 2001 Mar 2. To compare the properties of V-ATPases containing Vph1p or Stv1p, Stv1p was expressed at higher than normal levels in a strain disrupted in both genes, under which conditions V-ATPase complexes containing Stv1p appear in the vacuole. Both exhibited a K (m) for ATP of about 250 microm, and both showed resistance to sodium azide and vanadate and sensitivity to nanomolar concentrations of concanamycin A. |
1(0,0,0,1) | Details |
| 9570787 | Rose CR, Waxman SG, Ransom BR: Effects of deprivation, chemical hypoxia, and simulated ischemia on Na+ homeostasis in rat spinal cord astrocytes. J Neurosci. 1998 May 15;18(10):3554-62. Combined glycolytic and respiratory blockage by NaN3 and 0 saline caused [Na+] i to increase by 20 mM, similar to the [Na+] i increases elicited by blocking the Na+/K+-ATPase with ouabain. |
1(0,0,0,1) | Details |
| 15488293 | Grammatopoulos TN, Johnson V, Moore SA, Andres R, Weyhenmeyer JA: Angiotensin type 2 receptor neuroprotection against chemical hypoxia is dependent on the delayed rectifier K+ channel, Na+/Ca2+ exchanger and Na+/K+ ATPase in primary cortical cultures. Neurosci Res. 2004 Nov;50(3):299-306. Sodium azide (10mM) induced apoptosis in 40% of neurons. |
1(0,0,0,1) | Details |
| 14629005 | Alves-Ferreira M, Dutra PM, Lopes AH, Ferreira-Pereira A, Scofano HM, Meyer-Fernandes JR: -dependent ecto-ATP diphosphohydrolase activity in Herpetomonas muscarum muscarum. Curr Microbiol. 2003 Oct;47(4):265-71. The ecto-ATPase activity was insensitive to oligomycin and sodium azide, two inhibitors of mitochondrial Mg-ATPase, bafilomycin A1, a V-ATPase inhibitor, ouabain, a Na (+)+K+-ATPase inhibitor and to levamizole, an inhibitor of alkaline phosphatase. The ecto-ATPase activity was insensitive to oligomycin and sodium azide, two inhibitors of mitochondrial Mg-ATPase, bafilomycin A1, a V-ATPase inhibitor, ouabain, a Na (+)+K+-ATPase inhibitor and to levamizole, an inhibitor of alkaline phosphatase. |
1(0,0,0,1) | Details |
| 8768517 | Aparicio G, Buche A, Mendez C, Salas JA: Characterization of the ATPase activity of the N-terminal nucleotide binding domain of an ABC transporter involved in oleandomycin secretion by Streptomyces antibioticus. FEMS Microbiol Lett. 1996 Aug 1;141(2-3):157-62. ATPase activity was resistant to specific inhibitors of P-, F-, and V-type ATPase whereas sodium azide and 7-chloro-4-nitrobenzo-2-oxa- (NBD-C1) were strong inhibitors. The results suggest that the intrinsic ATPase activity of purified fusion protein can be clearly distinguished from other ATP-hydrolysing enzymes, including ion-translocating ATPases or ABC-traffic ATPases, both on the basis of inhibition by different agents and since it hydrolyzes ATP without interacting with a hydrophobic membrane component. |
1(0,0,0,1) | Details |
| 15050517 | Borges E, Cognato Gde P, Vuaden FC, Bogo MR, Fauth Mda G, Bonan CD, Dias RD: Nucleotidase activities in membrane preparations of nervous ganglia and digestive gland of the snail Helix aspersa. Comp Biochem Physiol B Biochem Mol Biol. 2004 Mar;137(3):297-307. In nervous ganglia, the enzyme was insensitive to the classical ATPases inhibitors. Sodium azide, at 100 microM and 20 mM, inhibited Mg (2+)-ATP hydrolysis by 36% and 55% in digestive gland, respectively. |
1(0,0,0,1) | Details |
| 11742758 | Da Silva RS, de Paula Cognato G, Bogo MR, da Graca Fauth M, Fin CA, Thome JW, Bonan CD, Dutra Dias R: Unique Ca (2+)-activated ATPase in the nervous ganglia of Phyllocaulis soleiformis (Mollusca). Comp Biochem Physiol B Biochem Mol Biol. 2002 Jan;131(1):55-61. Ca (2+)-ATPase activity was insensitive to the classical ATPase inhibitors ouabain, N-ethylmaleimide, orthovanadate and sodium azide. |
0(0,0,0,0) | Details |
| 10393565 | Lee K, Thakker DR: Saturable transport of H2-antagonists and across Caco-2 cell monolayers. J Pharm Sci. 1999 Jul;88(7):680-7. Na+, K+-ATPase inhibitor ouabain and metabolic inhibitors sodium azide + 2-deoxy- did not affect transport, suggesting that the active transport was not involved. |
0(0,0,0,0) | Details |
| 18422631 | Borges FP, de Brum Vieira P, Wiltuschnig RC, Tasca T, De Carli GA, Bonan CD: Characterization of nucleoside diphosphohydrolase activity in Trichomonas gallinae and the influence of penicillin and streptomycin in extracellular nucleotide hydrolysis. FEMS Microbiol Lett. 2008 Jun;283(2):189-95. Epub 2008 Apr 14. Contaminant activities were ruled out because the enzyme was not inhibited by classical inhibitors of ATPases (ouabain, 5.0 mM sodium azide, oligomycin) and alkaline phosphatases (levamisole). |
0(0,0,0,0) | Details |
| 11862992 | Coimbra ES, Goncalves-da-Costa SC, Corte-Real S, De Freitas FG, Durao AC, Souza CS, Silva-Santos MI, Vasconcelos EG: Characterization and cytochemical localization of an ATP diphosphohydrolase from Leishmania amazonensis promastigotes. Parasitology. 2002 Feb;124(Pt 2):137-43. Sodium azide (5-10 mM) caused inhibition of the ATP and ADP hydrolysis in a dose-dependent manner. |
0(0,0,0,0) | Details |
| 8040116 | Mtairag EM, Abdelghaffar H, Labro MT: Investigation of dirithromycin and erythromycylamine uptake by human neutrophils in vitro. J Antimicrob Chemother. 1994 Mar;33(3):523-36. Metabolic inhibitors (2-4 dinitrophenol, and sodium azide) did not impair the uptake of either drug but, interestingly, ouabain, an inhibitor of membrane Na+/K+ ATPase activity, impaired uptake by about 30%. |
0(0,0,0,0) | Details |
| 19286983 | Bagar T, Altenbach K, Read ND, Bencina M: Live-Cell imaging and measurement of intracellular pH in filamentous fungi using a genetically encoded ratiometric probe. Eukaryot Cell. 2009 May;8(5):703-12. Epub 2009 Mar 13. The inhibition of ATPases with N-ethylmaleimide, dicychlohexylcarbodimide, or sodium azide caused the cytoplasmic pH to decrease by <1 pH unit. |
81(1,1,1,1) | Details |
| 7486907 | Belli WA, Fryklund J: Partial characterization and effect of on ATPase activity in Helicobacter pylori by using permeabilized cells. Antimicrob Agents Chemother. 1995 Aug;39(8):1717-20. The ATPase activities in these cells were most susceptible to sodium azide, fluoroaluminate, and dicyclohexylcarbodiimide, which are typical inhibitors of F ATPases. |
81(1,1,1,1) | Details |
| 10681547 | Sevigny J, Robson SC, Waelkens E, Csizmadia E, Smith RN, Lemmens R: Identification and characterization of a novel hepatic canalicular ATP diphosphohydrolase. J Biol Chem. 2000 Feb 25;275(8):5640-7. Biochemical activity was unaffected by sodium azide or other inhibitors of ATPases. |
82(1,1,1,2) | Details |
| 7761265 | Ziganshin AU, Ziganshina LE, King BE, Burnstock G: Characteristics of ecto-ATPase of Xenopus oocytes and the inhibitory actions of suramin on ATP breakdown. Pflugers Arch. 1995 Jan;429(3):412-8. Ecto-ATPase activity was unaffected by ouabain (100 microM), sodium azide (100 microM), and oligomycin (5 micrograms/ml) (as inhibitors of endo-ATPases) and beta-glycerophosphate (10 mM) and p-nitrophenyl (10 mM) (as inhibitors of non-specific alkaline phosphatase). |
81(1,1,1,1) | Details |
| 16327018 | Qamirani E, Razavi HM, Wu X, Davis MJ, Kuo L, Hein TW: Sodium azide dilates coronary arterioles via activation of inward rectifier K+ channels and Na+-K+-ATPase. Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1617-23. Epub 2005 Dec 3. |
81(1,1,1,1) | Details |
| 9972316 | Podsiadlowski L, Matha V, Vilcinskas A: Detection of a P-glycoprotein related pump in Chironomus larvae and its inhibition by and cyclosporin A. Comp Biochem Physiol B Biochem Mol Biol. 1998 Dec;121(4):443-50. This increase was unaffected by inhibitors of other membrane ATPases (sodium azide, EGTA, ouabain), but sensitive to vanadate, cyclosporin A and which inhibit mammalian P-glycoprotein mediated ATP-consumption. |
31(0,1,1,1) | Details |
| 8083192 | RayChaudhuri D, Park JT: A point mutation converts Escherichia coli FtsZ septation GTPase to an ATPase. J Biol Chem. 1994 Sep 16;269(37):22941-4. This activity, unlike the wild-type GTPase, is specifically inhibited by sodium azide, a known antagonist of F-type ATPases and the bacterial SecA protein translocation ATPase (Oliver, D., Cabelli, R. |
81(1,1,1,1) | Details |
| 16770322 | Shahidullah M, Delamere NA: NO donors inhibit Na,K-ATPase activity by a protein kinase G-dependent mechanism in the nonpigmented ciliary epithelium of the porcine eye. Br J Pharmacol. 2006 Jul;148(6):871-80. Epub 2006 Jun 12. The inhibitory effect of SNP or sodium azide on Na,K-ATPase activity was suppressed by soluble guanylate cyclase (sGC) inhibitors, ODQ (10 microM) or methylene blue (10 microM). 6. |
33(0,1,1,3) | Details |
| 11007172 | Furriel RP, McNamara JC, Leone FA: Characterization of (Na+, K+)-ATPase in gill microsomes of the freshwater shrimp Macrobrachium olfersii. Comp Biochem Physiol B Biochem Mol Biol. 2000 Jul;126(3):303-15. The remaining 30% activity was inhibited by oligomycin, sodium azide and bafilomycin A. |
5(0,0,0,5) | Details |
| 14758500 | Birkedal R, Gesser H: Regulation of mitochondrial energy production in cardiac cells of rainbow trout (Oncorhynchus mykiss). J Comp Physiol B. 2004 Apr;174(3):255-62. Epub 2004 Feb 3. In skinned rat cardiac fibres, mitochondrial affinity for endogenous ADP generated by kinase and Ca2+-activated ATPases is higher than for exogenous ADP added to the surrounding medium, suggesting that mitochondria are functionally coupled to kinase and ATPases. |
3(0,0,0,3) | Details |
| 9226881 | Specht SC, Rodriguez C, Quinones L, Velazquez S: Effect of high ionic strength and inhibitors of H,K-ATPase on the ouabain-sensitive K-p-nitrophenylphosphatase activity in the sea anemone Stichodactyla helianthus. Comp Biochem Physiol B Biochem Mol Biol. 1997 Jun;117(2):217-24. The ouabain-sensitive, K-stimulated p-nitrophenyl phosphatase (K-pNPPase) activity, an associated activity of the Na,K-ATPase, was assayed in tentacles of the sea anemone Stichodactyla helianthus to investigate the possibility that the sea anemone Na,K-ATPase activity is an associated activity of an H,K-ATPase. Activity of the sea anemone enzyme was inhibited by 10 microM ammonium vanadate, an inhibitor of P-type ATPase, and not by 2.5 mM sodium azide, an inhibitor of both F-type and V-type ATPase. |
2(0,0,0,2) | Details |