Protein Information

Name interstitial collagenase
Synonyms CLG; CLGN; Fibroblast collagenase; Interstitial collagenase; Interstitial collagenase precursor; MMP 1; MMP1; MMP1 protein…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
9280289 Wlaschek M, Wenk J, Brenneisen P, Briviba K, Schwarz A, Sies H, Scharffetter-Kochanek K: Singlet oxygen is an early intermediate in cytokine-dependent ultraviolet-A induction of interstitial collagenase in human dermal fibroblasts in vitro. FEBS Lett. 1997 Aug 18;413(2):239-42.

These effects are enhanced in deuterium oxide-based medium and are diminished in the presence of non-toxic concentrations of sodium azide.
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7829875 Wlaschek M, Briviba K, Stricklin GP, Sies H, Scharffetter-Kochanek K: Singlet oxygen may mediate the ultraviolet A-induced synthesis of interstitial collagenase. J Invest Dermatol. 1995 Feb;104(2):194-8.

In contrast, sodium azide, a potent quencher of singlet oxygen, almost totally abrogated the induction of collagenase after exposure of fibroblasts to NDPO2 or to UVA irradiation.
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8375513 Scharffetter-Kochanek K, Wlaschek M, Briviba K, Sies H: Singlet oxygen induces collagenase expression in human skin fibroblasts. . FEBS Lett. 1993 Oct 4;331(3):304-6.

Singlet oxygen generated in a dark reaction by thermodissociation of an endoperoxide (NDPO2) elicits an increase in mRNA of interstitial collagenase (MMP-1) in cultured human fibroblasts.
The effect is enhanced in deuterium oxide-based medium and is abolished in the presence of non-toxic doses of sodium azide.
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