Protein Information

Name SUR1
Synonyms ABC36; PHHI; MRP8; HI; ABCC 8; ABCC8; ATP binding cassette transporter sub family C member 8; HHF 1…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
10864893 McKay NG, Kinsella JM, Campbell CM, Ashford ML: Sensitivity of Kir6.2-SUR1 currents, in the absence and presence of sodium azide, to the K (ATP) channel inhibitors, ciclazindol and englitazone. Br J Pharmacol. 2000 Jun;130(4):857-66.
41(0,1,2,6) Details
11082117 Trapp S, Ashcroft FM: Direct interaction of Na-azide with the KATP channel. Br J Pharmacol. 2000 Nov;131(6):1105-12.

The effects of the metabolic inhibitor sodium azide were tested on excised macropatches from XENOPUS: oocytes expressing cloned ATP-sensitive potassium (KATP) channels of the Kir6.2/SUR1 type. 2.
33(0,1,1,3) Details
14872319 Dufer M, Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G: Oscillations of membrane potential and cytosolic Ca (2+) concentration in SUR1 (-/-) beta cells. Diabetologia. 2004 Mar;47(3):488-98. Epub 2004 Feb 11.

The depolarization of DeltaPsi evoked by sodium azide was significantly lower in SUR1 (-/-) than SUR1 (+/+) cells.
12(0,0,1,7) Details
13679426 Chen M, Dong Y, Simard JM: Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain. J Neurosci. 2003 Sep 17;23(24):8568-77.

4(0,0,0,4) Details
9135131 Gribble FM, Tucker SJ, Ashcroft FM: The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. EMBO J. 1997 Mar 17;16(6):1145-52.

3(0,0,0,3) Details
10050011 Lee K, Dixon AK, Richardson PJ, Pinnock RD: Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits. J Physiol. 1999 Mar 1;515 ( Pt 2):439-52.

In cell-attached recordings, removal of extracellular glucose or metabolic inhibition with sodium azide reduced the firing rate of a subpopulation of cells through the activation of a 65 pS channel that was blocked by the sulphonylureas tolbutamide and glibenclamide. 2.
1(0,0,0,1) Details
9705995 Lee K, Dixon AK, Freeman TC, Richardson PJ: Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneurones. J Physiol. 1998 Jul 15;510 ( Pt 2):441-53.

It is concluded that cholinergic interneurones within the rat striatum exhibit a KATP channel current and that this channel is formed from Kir6.1 and SUR1 subunits.
Using permeabilized patch recordings, neurones were shown to hyperpolarize in response to glucose deprivation or metabolic poisoning with sodium azide (NaN3).
1(0,0,0,1) Details
10516647 Surah-Narwal S, Xu SZ, McHugh D, McDonald RL, Hough E, Cheong A, Partridge C, Sivaprasadarao A, Beech DJ: Block of human aorta Kir6.1 by the vascular KATP channel inhibitor U37883A. Br J Pharmacol. 1999 Oct;128(3):667-72.


Metabolic poisoning of Xenopus laevis oocytes with sodium azide and application of the K+ channel opener drug diazoxide induced K+ channel currents in oocytes co-injected with cRNA for hKir6.1 and hamster sulphonylurea receptor (SUR1), but not in oocytes injected with water or cRNA for hKir6.1 or SUR1 alone. 3.
0(0,0,0,0) Details