Protein Information

Name integrins
Synonyms Alpha 11 precursor; HsT18964; ITGA11; Integrin; Integrin alpha 11; Integrin alpha 11 precursor; MSTP018; HsT18964s…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
11967230 Tsuruta D, Gonzales M, Hopkinson SB, Otey C, Khuon S, Goldman RD, Jones JC: Microfilament-dependent movement of the beta3 integrin subunit within focal contacts of endothelial cells. FASEB J. 2002 Jun;16(8):866-8. Epub 2002 Apr 10.

7(0,0,0,7) Details
11781014 Kurtis MS, Tu BP, Gaya OA, Mollenhauer J, Knudson W, Loeser RF, Knudson CB, Sah RL: Mechanisms of chondrocyte adhesion to cartilage: role of beta1-integrins, CD44, and annexin V. J Orthop Res. 2001 Nov;19(6):1122-30.

6(0,0,0,6) Details
9334374 Yauch RL, Felsenfeld DP, Kraeft SK, Chen LB, Sheetz MP, Hemler ME: Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding. J Exp Med. 1997 Oct 20;186(8):1347-55.

5(0,0,0,5) Details
7523420 Wickham TJ, Filardo EJ, Cheresh DA, Nemerow GR: Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization. J Cell Biol. 1994 Oct;127(1):257-64.


Human adenovirus type 2 (Ad2) enters host cells by receptor-mediated endocytosis, an event mediated by the virus penton base binding to cell surface integrins alpha v beta 3 and alpha v beta 5.
2(0,0,0,2) Details
7583793 Jackola DR, Hallgren HM: Diminished cell-cell binding by lymphocytes from healthy, elderly humans: evidence for altered activation of LFA-1 function with age. J Gerontol A Biol Sci Med Sci. 1995 Nov;50(6):B368-77.

In both donor groups, aggregation by activated cells could be partially blocked by pretreating cells with monoclonal antibodies directed against the alpha and beta chains of the integrin leukocyte function-associated antigen-1 (LFA-1) (CD11a/CD18).
Further, aggregation was Ca2+/Mg2+ dependent, and the reaction required metabolically active cells, as the reaction was inhibited by the addition of sodium azide and 2-deoxy-D-glucose in both donor groups.
1(0,0,0,1) Details
8724599 Khaspekova SG, Vyzova TV, Lukin VV, Tikhomirov OIu, Berndt M, Kouns W, Mazurov AV: [Conformational changes of the platelet membrane glycoprotein IIb-IIIa complex stimulated by a monoclonal antibody to the N-terminal segment of glycoprotein IIIa]. Biokhimiia. 1996 Mar;61(3):412-28.

However, the platelet activation inhibitor, prostaglandin EI, and the mixture of metabolic inhibitors, deoxyglucose-sodium azide, only party inhibited the CRC54-dependent aggregation.
During platelet activation, the glycoprotein (GP) complex IIb-IIIa (alpha 11b beta 3-integrin) changes its conformation, resulting in binding of adhesive proteins of RGD containing an amino acid sequence as well as in expression of new ligand-induced binding sites (LIBS) on the GPIIb-IIIa molecule.
1(0,0,0,1) Details
12736272 Fujimoto TT, Katsutani S, Shimomura T, Fujimura K: Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphaIIbbeta3 by its extracellular domain. J Biol Chem. 2003 Jul 18;278(29):26655-65. Epub 2003 May 7.

Platelet aggregation induced by 4N1K was not completely inhibited by energy depletion with sodium azide and 2-deoxy-d-glucose, although ADP or collagen-induced platelet response was completely inhibited.
4(0,0,0,4) Details
7631157 Yang Y, Sammar M, Harrison JE, Lehnert K, Print CG, Leung E, Prestidge R, Krissansen GW: Construction and adhesive properties of a soluble MadCAM-1-Fc chimera expressed in a baculovirus system: phylogenetic conservation of receptor-ligand interaction. Scand J Immunol. 1995 Aug;42(2):235-47.

MAdCAM-1 is a high endothelial venule adhesion molecule composed of immunoglobulin and mucin-like domains which binds the leucocyte integrin LPAM-1 (alpha 4 beta 7), and is largely responsible for the selective homing of lymphocytes to mucosal tissues.
Binding was blocked by pretreatment of cells with sodium azide, and EDTA, indicating that binding is an energy-dependent process which requires divalent cations.
3(0,0,0,3) Details
10362101 Runnels JM, Chen N, Ortel B, Kato D, Hasan T: BPD-MA-mediated photosensitization in vitro and in vivo: cellular adhesion and beta1 integrin expression in ovarian cancer cells. Br J Cancer. 1999 Jun;80(7):946-53.

Photosensitized adhesion was reduced in the presence of sodium azide and enhanced in deuterium oxide, suggesting mediation by singlet oxygen.
2(0,0,0,2) Details
8898914 De Melker AA, Sonnenberg A: The role of the cytoplasmic domain of alpha 6 integrin in the assembly and function of alpha 6 beta 1 and alpha 6 beta 4. Eur J Biochem. 1996 Oct 1;241(1):254-64.

2(0,0,0,2) Details
7558718 O'Sullivan NL, Raja R, Montgomery PC: Lymphocyte adhesive interactions with lacrimal gland acinar epithelial cells in primary culture. Invest Ophthalmol Vis Sci. 1995 Oct;36(11):2246-53.


Thoracic duct lymphocyte binding required intact metabolic and membrane-cytoskeletal function and was inhibited by treating the lymphocytes with sodium azide, formaldehyde, or cytochalasin B (23%, 12%, and 10% of control binding, respectively).
0(0,0,0,0) Details