Protein Information

Name OCTN2
Synonyms CDSP; SCD; High affinity sodium dependent carnitine cotransporter; OCTN 2; OCTN2; Organic cation/carnitine transporter 2; SLC22A5; Solute carrier family 22 member 5…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
10504033 Yokogawa K, Miya K, Tamai I, Higashi Y, Nomura M, Miyamoto K, Tsuji A: Characteristics of L-carnitine transport in cultured human hepatoma HLF cells. J Pharm Pharmacol. 1999 Aug;51(8):935-40.

The recently cloned organic cation transporter, OCTN2, isolated as a homologue of OCTN1, has been shown to be of physiological importance in the renal tubular reabsorption of filtered L-carnitine as a high-affinity Na+ carnitine transporter in man.
The high affinity L-carnitine transporter was significantly inhibited by metabolic inhibitors (sodium azide, dinitrophenol, iodoacetic acid) and at low temperature (4 degrees C).
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18606742 Okura T, Hattori A, Takano Y, Sato T, Hammarlund-Udenaes M, Terasaki T, Deguchi Y: Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone. Drug Metab Dispos. 2008 Oct;36(10):2005-13. Epub 2008 Jul 7.


The transport was inhibited by metabolic inhibitors (rotenone and sodium azide) but was insensitive to extracellular sodium and membrane potential for both substrates.
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