Protein Information

Name LAT1
Synonyms 4F2; LAT 1; LAT1; CD98; 4F2 LC; 4F2 light chain; 4F2LC; CD98 light chain…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
12824232 Jain-Vakkalagadda B, Dey S, Pal D, Mitra AK: Identification and functional characterization of a Na+-independent large neutral amino acid transporter, LAT1, in human and rabbit cornea. Invest Ophthalmol Vis Sci. 2003 Jul;44(7):2919-27.

Inhibition studies were conducted in the presence of other L- and D-amino acids and metabolic inhibitors, such as ouabain and sodium azide, and in the absence of sodium to delineate the mechanism of uptake and transport.
6(0,0,0,6) Details
17998105 Nakajima S, Shikano N, Kotani T, Ogura M, Nishii R, Yoshimoto M, Yamaguchi N, Iwamura Y, Kubota N, Ishikawa N, Kawai K: Pharmacokinetics of 3-[125I] iodo-alpha-methyl-L-tyrosine, a tumor imaging agent, after probenecid loading in mice implanted with colon cancer DLD-1 cells. Nucl Med Biol. 2007 Nov;34(8):1003-8. Epub 2007 Sep 4.

In vitro inhibition study was then performed based on the accumulation mechanisms of [125I] IMT in DLD-1, using 1 mM l-tyrosine, BCH, alpha-(methylamino)-isobutyric acid, N-benzoyl-beta-alanine, PBC, PAH, 2,4-dinitrophenol and sodium azide.
We confirmed that [125I] IMT transport is predominantly mediated by l-type amino acid transporter-1 in DLD-1 cells.
1(0,0,0,1) Details