Protein Information

Name GSTP1 1
Synonyms DFN 7; PI; DFN7; FAEES 3; FAEES3; GST class pi; GST3; GSTP 1…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
8597579 Kura T, Takahashi Y, Takayama T, Ban N, Saito T, Kuga T, Niitsu Y: Glutathione S-transferase-pi is secreted as a monomer into human plasma by platelets and tumor cells. Biochim Biophys Acta. 1996 Feb 8;1292(2):317-23.

The release of GST-pi from cancer cells was suppressed at 4 degrees C, or by sodium azide, but not suppressed by colchicine or cytochalasin B.
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17964427 Kell A, Ventura N, Kahn N, Johnson TE: Activation of SKN-1 by novel kinases in Caenorhabditis elegans. Free Radic Biol Med. 2007 Dec 1;43(11):1560-6. Epub 2007 Sep 7.

The SKN-1 transcription factor specifies cell fate of the EMS blastomere at the four-cell stage in the nematode Caenorhabditis elegans and also directs transcription of many genes responding to oxidative stress, including glutathione S-transferase, NAD (P) H:quinone oxidoreductase, and superoxide dismutase.
SKN-1 localizes to the nucleus and directs transcription following exposure to paraquat, heat, hyperbaric oxygen, and sodium azide.
1(0,0,0,1) Details
10366541 Diah SK, Smitherman PK, Townsend AJ, Morrow CS: Detoxification of 1-chloro-2,4-dinitrobenzene in MCF7 breast cancer cells expressing glutathione S-transferase P1-1 and/or multidrug resistance protein 1. Toxicol Appl Pharmacol. 1999 Jun 1;157(2):85-93.


Moreover, combined expression of GSTP1-1 with MRP1 moderately augmented MRP1-mediated resistance to CDNB but only during short term (10 min) exposures to CDNB where IC50 values were in the 8-10 microM range.
1(0,0,0,1) Details