| Name | H:quinone oxidoreductase |
|---|---|
| Synonyms | Diaphorase; DHQU; DIA 4; DIA4; DT diaphorase; DTD; Diaphorase (NADH/NADPH); Diaphorase (NADH/NADPH) (cytochrome b 5 reductase)… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7525331 | Brouillet E, Hyman BT, Jenkins BG, Henshaw DR, Schulz JB, Sodhi P, Rosen BR, Beal MF: Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism. Exp Neurol. 1994 Oct;129(2):175-82. Sodium azide is an inhibitor of cytochrome oxidase which produces selective striatal lesions in both rodents and primates. Neurochemical and histologic evaluation showed that markers of both spiny projection neurons substance P) and aspiny interneurons (somatostatin, neuropeptide Y, -diaphorase) were equally affected. |
1(0,0,0,1) | Details |
| 11483385 | Shon YH, Nam KS: Antimutagenicity and induction of anticarcinogenic phase II enzymes by basidiomycetes. J Ethnopharmacol. 2001 Sep;77(1):103-9. Extracts from Phellinus linteus, Phellinus igniarius, and Agrocybe cylindracea have been tested for their antimutagenic properties against direct-acting mutagens [4-nitro-o-phenylenediamine (NPD) and sodium azide (NaN (3))] and indirect-acting mutagens [2-aminofluorene (2-AF) and benzo [a] pyrene (B [a] P)], using the Salmonella typhimurium tester strains TA 98 and TA 100. In addition, the chemopreventive potentials of these extracts to induce NAD (P) H:quinone oxidoreductase (QR) and glutathione S-transferase (GST) activities and (GSH) level extracts from the filtrate of the cultured broth of P. linteus, polysaccharide extracts from the cultured broth (PI I) and mycelia (PI II) and water extract of fruiting bodies (PI II) of P. igniarius, and polysaccharide extracts from the cultured broth (AC I) and mycelia (AC II) of A. cylindracea showed inhibitory effects on the mutagenic activities induced by the direct-acting mutagens, NPD and NaN (3), and the indirect-acting mutagens, 2-AF and B [a] P. |
1(0,0,0,1) | Details |
| 17964427 | Kell A, Ventura N, Kahn N, Johnson TE: Activation of SKN-1 by novel kinases in Caenorhabditis elegans. Free Radic Biol Med. 2007 Dec 1;43(11):1560-6. Epub 2007 Sep 7. The SKN-1 transcription factor specifies cell fate of the EMS blastomere at the four-cell stage in the nematode Caenorhabditis elegans and also directs transcription of many genes responding to oxidative stress, including glutathione S-transferase, NAD (P) H:quinone oxidoreductase, and superoxide dismutase. SKN-1 localizes to the nucleus and directs transcription following exposure to paraquat, heat, hyperbaric and sodium azide. |
1(0,0,0,1) | Details |
| 10193578 | Gutierrez-Correa J, Stoppani AO: Inactivation of myocardial dihydrolipoamide dehydrogenase by myeloperoxidase systems: effect of halides, and thiol compounds. Free Radic Res. 1999 Feb;30(2):105-17. The effect of the MPO/H2O2/NaNO2 system was prevented by MPO inhibitors (sodium azide, isoniazid, salicylhydroxamic acid) and also by and Dihydrolipoamide dehydrogenase (LADH) reductase activity decreased whereas enzyme diaphorase activity increased after LADH treatment with myeloperoxidase (MPO) dependent systems (MPO/H2O2/halide, MPO//halide and MPO/H2O2/ systems. |
1(0,0,0,1) | Details |
| 9211432 | Aitken RJ, Fisher HM, Fulton N, Gomez E, Knox W, Lewis B, Irvine S: Reactive species generation by human spermatozoa is induced by exogenous and inhibited by the flavoprotein inhibitors diphenylene iodonium and quinacrine. Mol Reprod Dev. 1997 Aug;47(4):468-82. Addition of to viable populations of motile spermatozoa induced a sudden dose-dependent increase in the rate of generation via mechanisms that could not be disrupted by inhibitors of the mitochondrial electron transport chain (antimycin A, rotenone, carbonyl m-chlorophenylhydrazone [CCCP], and sodium azide), diaphorase (dicoumarol) xanthine oxidase (allopurinol), or lactic acid dehydrogenase oxamate). |
0(0,0,0,0) | Details |
| 9343371 | Qiu XB, Cadenas E: The role of NAD (P) H:quinone oxidoreductase in -mediated p21 induction in human colon carcinoma cells. Arch Biochem Biophys. 1997 Oct 15;346(2):241-51. At variance with HT29 cells, H2O2 formation by BE cells was insensitive to the catalase inhibitor sodium azide. |
1(0,0,0,1) | Details |