| Name | xanthine oxidase |
|---|---|
| Synonyms | XDH; XDHA; XO; XOD; XOR; Xanthene dehydrogenase; Xanthine dehydrogenase; Xanthine dehydrogenase/oxidase… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18161508 | Ammar RB, Kilani S, Bouhlel I, Ezzi L, Skandrani I, Boubaker J, Sghaier MB, Naffeti A, Mahmoud A, Chekir-Ghedira L, Ghedira K: Antiproliferative, antioxidant, and antimutagenic activities of -enriched extracts from (Tunisian) Rhamnus alaternus L.: combination with the phytochemical composition. Drug Chem Toxicol. 2008;31(1):61-80. High DPPH radical-scavenging activity (7.21 and 18.84 microg/mL, respectively) and antioxidative effects using the xanthine oxidase assay (IC (50) values of 83.33 and 103.96 microg/mL, respectively) were detected in the presence of the two tested extracts. Although no mutagenic effect was observed when using the Salmonella typhimurium assay system with TA1535 and TA100 strains, the two tested extracts exhibited a high-level protection toward the direct mutagen, sodium azide-induced response. |
1(0,0,0,1) | Details |
| 18511029 | Ammar RB, Sghaier MB, Boubaker J, Bhouri W, Naffeti A, Skandrani I, Bouhlel I, Kilani S, Ghedira K, Chekir-Ghedira L: Antioxidant activity and inhibition of -, nifuroxazide-, and sodium azide-induced mutagenicity by extracts from Rhamnus alaternus L. Chem Biol Interact. 2008 Jul 10;174(1):1-10. Epub 2008 Jun 3. These same active extracts exhibited high xanthine oxidase (XOD) inhibiting with respective IC (50) values of 208 and 137 microg/ml, and -scavenging effects (IC (50) values of 132 and 117 microg/ml) when tested in the XOD enzymatic assay system. |
1(0,0,0,1) | Details |
| 12900405 | Emerson JP, Coulter ED, Phillips RS, Kurtz DM Jr: Kinetics of the reductase catalytic cycle. J Biol Chem. 2003 Oct 10;278(41):39662-8. Epub 2003 Aug 4. A proximal electron donor, rubredoxin, was used to supply reducing equivalents from via ferredoxin: NADP+ oxidoreductase, and /xanthine oxidase was used to provide a calibrated flux of |
1(0,0,0,1) | Details |
| 16447283 | Bizzozero OA, Ziegler JL, De Jesus G, Bolognani F: Acute depletion of causes extensive carbonylation of rat brain proteins. J Neurosci Res. 2006 Mar;83(4):656-67. Inhibition of catalase activity with sodium azide and aminotriazole, and peroxidase activity with mercaptosuccinic acid did not increase PCOs or TBARS, suggesting that increased production of reactive species (ROS) rather than compromised cellular antioxidant defenses is the cause for the accumulation of H2O2 after GSH depletion. |
0(0,0,0,0) | Details |
| 10561478 | Ohyashiki T, Nunomura M, Katoh T: Detection of radical in phospholipid liposomal membrane by fluorescence quenching method using 1,3-diphenylisobenzofuran. Biochim Biophys Acta. 1999 Sep 21;1421(1):131-9. The fluorescence intensity of DPBF incorporated in phospholipid liposomes consisting of (PC) and (PS) is effectively quenched by incubation with /xanthine oxidase system. On the other hand, catalase (1 U/ml), and and singlet scavengers (10 mM 300 mM 1 mM and 1 mM sodium azide) did not protect /xanthine oxidase-induced fluorescence quenching of DPBF-labeled liposomes. |
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| 9211432 | Aitken RJ, Fisher HM, Fulton N, Gomez E, Knox W, Lewis B, Irvine S: Reactive species generation by human spermatozoa is induced by exogenous and inhibited by the flavoprotein inhibitors diphenylene iodonium and quinacrine. Mol Reprod Dev. 1997 Aug;47(4):468-82. Addition of to viable populations of motile spermatozoa induced a sudden dose-dependent increase in the rate of generation via mechanisms that could not be disrupted by inhibitors of the mitochondrial electron transport chain (antimycin A, rotenone, carbonyl m-chlorophenylhydrazone [CCCP], and sodium azide), diaphorase (dicoumarol) xanthine oxidase (allopurinol), or lactic acid dehydrogenase oxamate). |
0(0,0,0,0) | Details |
| 7663419 | Mao Y, Zang L, Shi X: Singlet generation in the reaction. Biochem Mol Biol Int. 1995 May;36(1):227-32. Omission of xanthine oxidase or H2O2 caused a sharp decrease in 1O2 generation. 1O2 scavenger, sodium azide, inhibited 1O2 generation while .OH scavenger, only slightly decreased the signal intensity. |
32(0,1,1,2) | Details |
| 9801073 | Lacy F, Gough DA, Schmid-Schonbein GW: Role of xanthine oxidase in peroxide production. . Free Radic Biol Med. 1998 Oct;25(6):720-7. In the presence of sodium azide, an inhibitor of catalase, peroxide production was measured in plasma after adding or xanthine oxidase and the results were similar to those obtained in buffered saline. |
7(0,0,0,7) | Details |
| 7833505 | Demiryurek AT, Wainwright CL, Wadsworth RM, Kane KA: Characterization of a method for the detection of drugs with free radical scavenging activity using porcine leukocytes. J Pharmacol Toxicol Methods. 1994 Sep;32(1):35-40. The effects of a range of free-radical scavenging drugs on luminol-enhanced chemiluminescence (CL) generated by porcine leukocytes, following activation by two nonreceptor-mediated stimulants, phorbol (PMA; a protein kinase activator) and ionomycin (a cation ionophore), and by plus xanthine oxidase (X-XO), have been examined. Sodium azide (10 (-5) to 10 (-3) M) caused a marked inhibition in CL production in activated leukocytes, but not of X-XO CL. |
2(0,0,0,2) | Details |
| 19015021 | Skandrani I, Bouhlel I, Limem I, Boubaker J, Bhouri W, Neffati A, Ben Sghaier M, Kilani S, Ghedira K, Ghedira-Chekir L: Moricandia arvensis extracts protect against DNA damage, mutagenesis in bacteria system and scavenge the Toxicol In Vitro. 2009 Feb;23(1):166-75. Epub 2008 Oct 30. Our results showed that M. arvensis extracts possess antimutagenic effects against sodium azide (SA) in the two tested Salmonella assay systems, except metabolized aqueous and PE extracts when tested with S. typhimurium TA100 assay system. Antioxidant capacity of the tested extracts was evaluated using the enzymatic /xanthine oxidase assay) (X/XOD) and the non enzymatic (NBT/ assay) systems. |
2(0,0,0,2) | Details |
| 9125514 | Hunter T, Ikebukuro K, Bannister WH, Bannister JV, Hunter GJ: The conserved residue 34 is essential for maximal activity of iron-superoxide dismutase from Escherichia coli. Biochemistry. 1997 Apr 22;36(16):4925-33. Specific activities were measured using the -xanthine oxidase method and gave 3148 u/mg for wild-type FeSOD. SODY34F exhibited decreased thermal stability, reduced activity at high pH, and a pronounced increase in sensitivity to the inhibitor sodium azide compared with wild-type FeSOD. |
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| 9557922 | Lacy F, O'Connor DT, Schmid-Schonbein GW: Plasma peroxide production in hypertensives and normotensive subjects at genetic risk of hypertension. J Hypertens. 1998 Mar;16(3):291-303. Further investigations showed that is produced in plasma and that one of its sources is xanthine oxidase. METHODS: An electrode technique was used to determine plasma peroxide levels after blockade of endogenous catalase with sodium azide. |
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