Protein Information

Name Stress Activated Protein Kinase
Synonyms Mitogen activated protein kinase 8; JNK 1; JNK 46; JNK1; JNK1 alpha protein kinase; JNK1 beta protein kinase; JNK1A2; JNK21B1/2…

Compound Information

Name sodium azide
CAS sodium azide

Reference List

PubMed Abstract RScore(About this table)
9360968 Yu R, Tan TH, Kong AN: Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. J Biol Chem. 1997 Nov 14;272(46):28962-70.

Furthermore, BHA and tBHQ activation of ERK2 was strongly inhibited by ascorbic acid and a peroxidase inhibitor, sodium azide, suggesting the potential role of phenoxyl radicals and/or their derivatives.
Here we demonstrate that BHA is capable of activating distinct mitogen-activated protein kinases (MAPKs), extracellular signal-regulated protein kinase 2 (ERK2), and c-Jun N-terminal kinase 1 (JNK1).
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17384288 Siniscalchi A, Cavallini S, Marino S, Falzarano S, Franceschetti L, Selvatici R: Effects of chemical ischemia on cerebral cortex slices: focus on mitogen-activated protein kinase cascade. Ann N Y Acad Sci. 2006 Dec;1090:445-54.

In superfused, electrically stimulated rat cerebral cortex slices, chemical ischemia (CI) was induced by a 5-min treatment with the mitochondrial toxin, sodium azide (10 mM), combined with the glycolysis blocker, 2-deoxyglucose (2 mM).
Western blot analysis of p21Ras, extracellular signal-regulated protein kinases (ERK) 1/2 (p44/42), phospho-ERK1/2, mitogen-activated protein kinase (MAPK)-p38, phospho-p38, stress-activated protein kinases/c-Jun NH2-terminal protein kinases (SAPK/JNK), phospho-SAPK/JNK was carried out.
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9788740 Behrooz A, Ismail-Beigi F: Induction of GLUT1 mRNA in response to azide and inhibition of protein synthesis. Mol Cell Biochem. 1998 Oct;187(1-2):33-40.


The induction of GLUT1 mRNA by anisomycin was half-maximal at approximately 3 microM, whereas inhibition of leucine incorporation and stimulation of Stress Activated Protein Kinase (SAPK), measured as c-Jun N-terminal kinase activity, were half-maximal at approximately 0.3 and approximately 0.05 microM anisomycin, respectively.
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12945585 Le Panse R, Dubertret L, Coulomb B: p38 mitogen-activated protein kinase activation by ultraviolet A radiation in human dermal fibroblasts. Photochem Photobiol. 2003 Aug;78(2):168-74.


L-Histidine and sodium azide had an inhibitory effect on UVA activation of p38 MAPK, pointing to a role of singlet oxygen in transduction of the UVA effect.
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