| Name | GS X |
|---|---|
| Synonyms | ABC29; MRP; MRP1; ABCC; ABCC 1; ABCC1; ATP binding cassette subfamily C member1; ATP binding cassette sub family C member 1… |
| Name | sodium azide |
|---|---|
| CAS | sodium azide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10366541 | Diah SK, Smitherman PK, Townsend AJ, Morrow CS: Detoxification of 1-chloro-2,4-dinitrobenzene in MCF7 breast cancer cells expressing glutathione S-transferase P1-1 and/or multidrug resistance protein 1. Toxicol Appl Pharmacol. 1999 Jun 1;157(2):85-93. We examined the roles of glutathione S-transferase (GST) P1-1 and the S-conjugate (GS-X) transporter, multidrug resistance protein 1 (MRP1), singly or in combination, in the detoxification of 1-chloro-2,4-dinitrobenzene (CDNB). |
10(0,0,0,10) | Details |
| 15486199 | Loganzo F, Hari M, Annable T, Tan X, Morilla DB, Musto S, Zask A, Kaplan J, Minnick AA Jr, May MK, Ayral-Kaloustian S, Poruchynsky MS, Fojo T, Greenberger LM: Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin. Mol Cancer Ther. 2004 Oct;3(10):1319-27. These data suggest that HTI-286 resistance may be partially mediated by mutation of alpha-tubulin and by an ATP-binding cassette drug pump distinct from P-glycoprotein, ABCG2, MRP1, or MRP3. Sodium azide treatment partially reversed low HTI-286 accumulation, suggesting involvement of an ATP-dependent drug pump. |
1(0,0,0,1) | Details |
| 12893836 | Dallas S, Zhu X, Baruchel S, Schlichter L, Bendayan R: Functional expression of the multidrug resistance protein 1 in microglia. J Pharmacol Exp Ther. 2003 Oct;307(1):282-90. Epub 2003 Jul 31. Vincristine accumulation by monolayers of MLS-9 cells increased significantly in the presence of several well established MRP1 inhibitors (MK571, sulfinpyrazone, probenecid, and indomethacin), protease inhibitors, or the ATPase inhibitor sodium azide. |
36(0,1,1,6) | Details |
| 12750271 | Grzywacz MJ, Yang JM, Hait WN: Effect of the multidrug resistance protein on the transport of the antiandrogen flutamide. Cancer Res. 2003 May 15;63(10):2492-8. Finally, intracellular depletion with buthionine sulfoximine or energy depletion using 2-deoxy-/sodium azide restored flutamide accumulation to that of parental cells while incubating the cells at 4 degrees C abolished MRP1-mediated transport. |
35(0,1,1,5) | Details |
| 20190417 | Ishikawa Y, Nagai J, Okada Y, Sato K, Yumoto R, Takano M: Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol Pharm Bull. 2010;33(3):504-11. Conventional RT-PCR analysis showed the expression of multidrug resistance 1 (MDR1), MRP1, MRP2 and lung resistance-related protein (LRP) mRNAs. The accumulation of doxorubicin was increased in the presence of metabolic inhibitors (10 mM 2-deoxyglucose and 5 mM sodium azide). |
2(0,0,0,2) | Details |
| 11288109 | Hamilton KO, Backstrom G, Yazdanian MA, Audus KL: P-glycoprotein efflux pump expression and activity in Calu-3 cells. J Pharm Sci. 2001 May;90(5):647-58. The metabolic inhibitor sodium azide decreased the efflux of Rh123 out of Calu-3 cells to the same degree as CsA, supporting inhibition of an active, efflux pathway. |
0(0,0,0,0) | Details |
| 10930538 | Yang CH, Schneider E, Kuo ML, Volk EL, Rocchi E, Chen YC: BCRP/MXR/ABCP expression in topotecan-resistant human breast carcinoma cells. Biochem Pharmacol. 2000 Sep 15;60(6):831-7. Topotecan efflux was increased in MCF7/TPT300 cells compared with MCF7/WT cells, and this increase was reversed upon ATP depletion by sodium azide, suggesting an energy-dependent drug efflux mechanism. |
0(0,0,0,0) | Details |