Protein Information

Name plasminogen
Synonyms A; Apo(a); APOA2; Plasminogen; APOA 2; Angiostatin; Apolipoprotein A II; Microplasmin…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
2829391 Lison D, Dubois P, Lauwerys R: In vitro effect of mercury and vanadium on superoxide anion production and plasminogen activator activity of mouse peritoneal macrophages. Toxicol Lett. 1988 Jan;40(1):29-36.

The in vitro effects of mercuric chloride and vanadate were examined on two functions of mouse peritoneal macrophages, i.e., the superoxide anion production and the plasminogen activator (PA) activity.
32(0,1,1,2) Details
2255679 Lison D, Raguzzi F, Lauwerys R: Comparison of the effects of auranofin, heavy metals and retinoids on protein kinase C in vitro and on a protein kinase C mediated response in macrophages. Pharmacol Toxicol. 1990 Sep;67(3):239-42.

The effect of auranofin (AF), retinoic acid (RA), and three heavy metals reacting with thiol groups (Hg, Cd, Pb) has been compared on a PKC mediated response of intact macrophages (i.e. plasminogen activator (PA) induction) and on purified PKC activity.
In vitro, and in absence of chelators, mercuric chloride is also a potent inhibitor of PKC.
1(0,0,0,1) Details
3146750 Michalska M, Mirowski M, Wierzbicki R: Coagulation and fibrinolysis in rats poisoned with mercuric chloride. . Pol J Pharmacol Pharm. 1988 Jul-Aug;40(4):365-71.

The main reason of the lowered fibrinolytic activity seemed to be the inhibition of plasma plasminogen activator or the inhibition of plasminogen activation reaction catalyzed by this enzyme.
1(0,0,0,1) Details