Protein Information

Name CD134
Synonyms ACT35; ACT35 antigen; CD134; CD134 antigen; Lymphoid activation antigen ACT35; OX40; OX40 antigen; OX40L receptor…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
9766631 Roos A, Schilder-Tol EJ, Weening JJ, Aten J: Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment. J Leukoc Biol. 1998 Oct;64(4):503-10.

8(0,0,0,8) Details
9388500 Roos A, Claessen N, Schilder-Tol EJ, Chand MA, Weening JJ, Aten J: Thiol levels in CD134-defined subsets of rat T lymphocytes: possible implications for HgCl2-induced immune dysregulation. Biochem Biophys Res Commun. 1997 Nov 17;240(2):452-7.

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9790309 Roos A, Claessen N, Schilder-Tol EJ, Weening JJ, Aten J: Differential expression of T-cell adhesion molecules and LFA-1-dependent intercellular adhesion in HgCl2-induced autoimmunity and immune suppression. Scand J Immunol. 1998 Oct;48(4):389-96.


HgCl2 was previously found to enhance expression of LFA-1, ICAM-1 and CD134 (OX40) on T cells in BN rats.
3(0,0,0,3) Details
16476060 MacPhee IA, Yagita H, Oliveira DB: Blockade of OX40-ligand after initial triggering of the T helper 2 response inhibits mercuric chloride-induced autoimmunity. Immunology. 2006 Mar;117(3):402-8.

Treatment with antibody to OX40-ligand (OX40-L) from the time of the first HgCl2 injection for 12 days had little effect.
3(0,0,0,3) Details
8633208 Roos A, Claessen N, Weening JJ, Aten J: Enhanced T lymphocyte expression of LFA-1, ICAM-1, and the TNF receptor family member OX40 in HgCl2-induced systemic autoimmunity. Scand J Immunol. 1996 May;43(5):507-18.

Injection of mercuric chloride into Brown Norway (BN) rats induces a T lymphocyte-dependent autoimmune syndrome.
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10886235 Cederbrant K, Hultman P: Characterization of mercuric mercury (Hg2+)-induced lymphoblasts from patients with mercury allergy and from healthy subjects. Clin Exp Immunol. 2000 Jul;121(1):23-30.


The immunophenotype and the T cell receptor Vbeta (TCR Vbeta) repertoire of Hg2+-induced lymphoblasts as well as the expression of the lymphocyte activation markers CD23 and CD134 were analysed for possible differences between healthy and allergic subjects.
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