| Name | MAPK (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9779822 | Akhand AA, Kato M, Suzuki H, Miyata T, Nakashima I: Level of HgCl2-mediated phosphorylation of intracellular proteins determines death of thymic T-lymphocytes with or without DNA fragmentation. J Cell Biochem. 1998 Nov 1;71(2):243-53. Analysis of proteins by both one- and two-dimensional electrophoresis and immunoblot showed that a 52-kDa Shc protein was heavily phosphorylated by an early signal delivered by a high concentration of Hg2+, which also phosphorylated extracellular signal-regulated kinase 1 (ERK1; p44) and ERK2 (p42) of the mitogen-activated protein kinase (MAPK) family in a concentration- and time-dependent manner. |
2(0,0,0,2) | Details |
| 15050407 | Kim SH, Sharma RP: Mercury-induced apoptosis and necrosis in murine macrophages: role of -induced reactive species and p38 mitogen-activated protein kinase signaling. Toxicol Appl Pharmacol. 2004 Apr 1;196(1):47-57. The cytotoxic EC (50) of mercury ranged from 62.7 to 81.1 microM by various assays in J774A.1 cultures; accordingly, we employed 70 microM of mercuric chloride in most experiments. |
2(0,0,0,2) | Details |
| 17056058 | Kidokoro K, Iwata K, Takeda M, Fujiwara Y: Involvement of ERK/MAPK in regulation of diapause intensity in the false melon beetle, Atrachya menetriesi. J Insect Physiol. 2006 Nov-Dec;52(11-12):1189-93. Epub 2006 Sep 16. |
2(0,0,0,2) | Details |
| 16997801 | Choi CH, Bark H, Chung JM, Park EK, Kim SH: Elevated reactive species but not regulate mercury resistance to AML-2/DX100 cells. Immunopharmacol Immunotoxicol. 2006;28(3):545-55. This study was designed to investigate the role of reactive species (ROS) and on the resistance of AML-2/DX100 cells to mercuric chloride. The specific inhibitor for p38 MAPK and ERK, and antioxidant decreased the production of MRP1 and therefore resistance of AML-2/DX100 cells against mercury exposure. |
2(0,0,0,2) | Details |
| 11104828 | Matsuoka M, Wispriyono B, Iryo Y, Igisu H, Sugiura T: Inhibition of HgCl2-induced mitogen-activated protein kinase activation by LL-Z1640-2 in CCRF-CEM cells. Eur J Pharmacol. 2000 Dec 8;409(2):155-8. |
2(0,0,0,2) | Details |
| 15226156 | Jia Z, Person MD, Dong J, Shen J, Hensley SC, Stevens JL, Monks TJ, Lau SS: Grp78 is essential for 11-deoxy-16,16-dimethyl -mediated cytoprotection in renal epithelial cells. Am J Physiol Renal Physiol. 2004 Dec;287(6):F1113-22. Epub 2004 Jun 29. We have now determined the ability of DDM-PGE (2) to protect against other renal toxicants and report that DDM-PGE (2) only protects against oncotic cell death, induced by H (2) O (2), iodoacetamide, and TGHQ, but not against apoptotic cell death induced by cisplatin, mercuric chloride, or tumor necrosis factor-alpha. Moreover, TGHQ-induced p38 MAPK activation is disrupted under conditions of a compromised ER stress response in pkASgrp78 cells, which likely contributes to the loss of cytoprotection. |
1(0,0,0,1) | Details |
| 7539434 | Katano Y, Pu MY, Akhand AA, Hamaguchi M, Koga Y, Isobe K, Fukuda Y, Hayakawa T, Nakashima I: Evidence of redox-linked signaling for producing a giant signal complex. . J Cell Biochem. 1995 Mar;57(3):432-9. The pellet fraction was further found to include some other signal delivery elements, such as GTPase activating protein, phosphatidylinositol 3 kinase, and mitogen-activated protein kinase. |
1(0,0,0,1) | Details |