Protein Information

Name AQP2
Synonyms ADH water channel; AQP 2; AQP CD; AQP2; Aquaporin 2; Aquaporin CD; Collecting duct water channel protein; WCH CD…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
8617798 Bai L, Fushimi K, Sasaki S, Marumo F: Structure of aquaporin-2 vasopressin water channel. J Biol Chem. 1996 Mar 1;271(9):5171-6.

2(0,0,0,2) Details
9369468 Kuwahara M, Gu Y, Ishibashi K, Marumo F, Sasaki S: Mercury-sensitive residues and pore site in AQP3 water channel. Biochemistry. 1997 Nov 18;36(46):13973-8.


Mutation of Tyr-212, a position corresponding to the mercury-sensitive residues in AQP1 and AQP2, to cysteine enhanced the mercurial inhibition of Pf.
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9829975 Meinild AK, Klaerke DA, Zeuthen T: Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5. J Biol Chem. 1998 Dec 4;273(49):32446-51.


The reflection coefficients (sigma) of urea, glycerol, acetamide, and formamide at 23 degreesC were: AQP0: 1, 1, 0.8, 0.6; AQP1: 1, 0.8, 1, 1; AQP2: 1, 0.8, 1, 1; AQP3: 1, 0.2, 0.7, 0.4; AQP4: 1, 0.9, 1, 1; and AQP5: 1, 1, 1, 0.8.
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18344486 Philip BN, Yi SX, Elnitsky MA, Lee RE Jr: Aquaporins play a role in desiccation and freeze tolerance in larvae of the goldenrod gall fly, Eurosta solidaginis. J Exp Biol. 2008 Apr;211(Pt 7):1114-9.

Immunoblotting with mammalian anti-AQP2, -AQP3 and -AQP4 revealed corresponding aquaporin homologues in E. solidaginis, whose patterns of expression varied depending on acclimation temperature and desiccation treatment.
To examine the role of aquaporins in freeze tolerance, we froze fat body, midgut and salivary gland tissues in the presence and absence of mercuric chloride, an aquaporin inhibitor.
1(0,0,0,1) Details
9321919 Mulders SM, Rijss JP, Hartog A, Bindels RJ, van Os CH, Deen PM: Importance of the mercury-sensitive cysteine on function and routing of AQP1 and AQP2 in oocytes. Am J Physiol. 1997 Sep;273(3 Pt 2):F451-6.

6(0,0,0,6) Details