| Name | CD4 |
|---|---|
| Synonyms | CD4; CD4 antigen (p55); CD4 molecule; CD4mut; T cell antigen T4/LEU3; T cell surface glycoprotein CD4; T cell surface antigen T4/Leu 3; T cell surface glycoprotein CD4 precursor… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7507957 | Nakashima I, Pu MY, Nishizaki A, Rosila I, Ma L, Katano Y, Ohkusu K, Rahman SM, Isobe K, Hamaguchi M, et al.: Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals. J Immunol. 1994 Feb 1;152(3):1064-71. Through the cross-linkage by thiol-reactive bivalent mercury, transmembrane CD4, CD3, and CD45 and glycosylphosphatidylinositol-anchored Thy-1 were aggregated together on thymocytes or T lymphocytes. |
2(0,0,0,2) | Details |
| 8102566 | van Vliet E, Uhrberg M, Stein C, Gleichmann E: MHC control of IL-4-dependent enhancement of B cell Ia expression and Ig class switching in mice treated with mercuric chloride. Int Arch Allergy Immunol. 1993;101(4):392-401. The development of these HgCl2-induced immunological alterations requires CD4+ T cells. |
1(0,0,0,1) | Details |
| 18641331 | Fagoonee S, Caorsi C, Giovarelli M, Stoltenberg M, Silengo L, Altruda F, Camussi G, Tolosano E, Bussolati B: Lack of plasma protein hemopexin dampens mercury-induced autoimmune response in mice. J Immunol. 2008 Aug 1;181(3):1937-47. Interestingly, CD4 (+) T cells isolated from mercury-treated hemopexin-null mice show reduced IFN-gamma-dependent STAT1 phosphorylation compared with that of wild-type mice. Hemopexin-null mice produced fewer antinuclear autoantibodies and had reduced deposits of immune complexes in the kidney after mercuric chloride treatment compared with wild-type mice. |
1(0,0,0,1) | Details |
| 8972737 | Jiang Y, Moller G: Unresponsiveness of CD4+ T cells from a non-responder strain to HgCl2 is not due to CD8 (+)-mediated immunosuppression: an analysis of the very early activation antigen CD69. Scand J Immunol. 1996 Dec;44(6):565-70. Since CD8+ T cells have been described as mediating immunosuppression and as being responsible for the resistance to autoimmune induction by mercury, the authors tested whether CD8+ T cells inhibited the activation of CD4+ T cells by HgCl2 in the non-responder strains. |
1(0,0,0,1) | Details |
| 7871386 | Gillespie KM, Qasim FJ, Tibbatts LM, Thiru S, Oliveira DB, Mathieson PW: Interleukin-4 gene expression in mercury-induced autoimmunity. Scand J Immunol. 1995 Mar;41(3):268-72. Mercuric chloride (HgCl2) induces autoimmunity in Brown Norway (BN) rats, with necrotizing vasculitis in the gut. Circumstantial evidence implicates the Th2 subset of CD4+ T lymphocytes, which produces IL-4. |
1(0,0,0,1) | Details |
| 11367541 | Pollard KM, Landberg GP: The in vitro proliferation of murine lymphocytes to mercuric chloride is restricted to mature T cells and is interleukin 1 dependent. Int Immunopharmacol. 2001 Mar;1(3):581-93. Both CD4+ and CD8+ T cells proliferated in response to HgCl2, but B cells and immature T cells (thymocytes) did not. |
1(0,0,0,1) | Details |
| 9766631 | Roos A, Schilder-Tol EJ, Weening JJ, Aten J: Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment. J Leukoc Biol. 1998 Oct;64(4):503-10. Regulation of CD134 expression on CD4+ T cells was further studied in vitro, identifying CD134 as an early marker of T cell activation. |
1(0,0,0,1) | Details |
| 9135547 | Hu H, Abedi-Valugerdi M, Moller G: Pretreatment of lymphocytes with mercury in vitro induces a response in T cells from genetically determined low-responders and a shift of the interleukin profile. Immunology. 1997 Feb;90(2):198-204. We found that in vitro mercuric chloride induced a high proliferative response in spleen lymphocytes from mercury-susceptible SJL mice, but a low response in resistant mice, such as C57BL/6 (H-2b), A/J (H-2a) and CBA (H-2k) mice. Both CD4+ and CD8+ T cells were activated in the restored response, but CD4+ T cells was the major responding cell population, as in high-responder mice. |
1(0,0,0,1) | Details |
| 7763084 | Nordlind K, Liden S: Gamma/delta T cells and human skin reactivity to heavy metals. Arch Dermatol Res. 1995;287(2):137-41. They were observed in all 14 allergic or irritant patch-test reactions to gold and in 6/8 such reactions to mercuric chloride, where they comprised 16 +/- 6% and 15 +/- 6%, respectively, of the CD3+ cells in the dermis. The gamma/delta cells expressed the V delta 2 and the V gamma 2 gene segments and were CD4-8-, indicating that they had the same phenotype as gamma/delta lymphocytes in the peripheral blood. |
1(0,0,0,1) | Details |
| 10886235 | Cederbrant K, Hultman P: Characterization of mercuric mercury (Hg2+)-induced lymphoblasts from patients with mercury allergy and from healthy subjects. Clin Exp Immunol. 2000 Jul;121(1):23-30. However, Hg2+-induced CD4+ lymphoblasts showed a skewing towards Vbeta2. |
1(0,0,0,1) | Details |
| 14599845 | Field AC, Bloch MF, Bellon B: Neonatal tolerance to a Th2-mediated autoimmune disease generates CD8+ Tc1 regulatory cells. J Autoimmun. 2003 Nov;21(3):201-12. Chronic exposure to mercury salts can lead to SLE-like autoimmune responses, mediated by autoreactive CD4+ Th2 cells, that regulate and are followed by a resistant state mediated by protective CD8+ T cells. |
1(0,0,0,1) | Details |
| 11564444 | Pelletier L, Savignac M, Xystrakis E, Duplan V, Druet P, Abdelhadi S: Self major histocompatibility complex class-II-specific regulatory CD4 T cells prevent both Th1- and Th2-mediated autoimmune diseases in the rat. Microbes Infect. 2001 Sep;3(11):955-60. |
1(0,0,0,1) | Details |
| 11334498 | Fournie GJ, Mas M, Cautain B, Savignac M, Subra JF, Pelletier L, Saoudi A, Lagrange D, Calise M, Druet P: Induction of autoimmunity through bystander effects. J Autoimmun. 2001 May;16(3):319-26. Genome-wide searches in the rat have shown that overlapping chromosomal regions control the immunological disorders induced by gold salt treatment, the development of experimental autoimmune encephalomyelitis and the CD45RC (high)/CD45RC (low) CD4 (+) T cells balance. |
1(0,0,0,1) | Details |
| 7612148 | Qasim FJ, Thiru S, Mathieson PW, Oliveira DB: The time course and characterization of mercuric chloride-induced immunopathology in the brown Norway rat. J Autoimmun. 1995 Apr;8(2):193-208. Within 48 h, HgCl2 caused a rise in the proportion of CD4+ T cells in spleen, LN and peripheral blood which then fell towards normal at peak tissue injury. |
1(0,0,0,1) | Details |
| 9790309 | Roos A, Claessen N, Schilder-Tol EJ, Weening JJ, Aten J: Differential expression of T-cell adhesion molecules and LFA-1-dependent intercellular adhesion in HgCl2-induced autoimmunity and immune suppression. Scand J Immunol. 1998 Oct;48(4):389-96. Furthermore, CD4+CD45RC (hi) T cells showed increased numbers of ICAM-1+ cells, whereas expression of CD134 and CD26 was relatively decreased in CD4+ T lymphoblasts. |
1(0,0,0,1) | Details |
| 8478610 | Mathieson PW, Thiru S, Oliveira DB: Regulatory role of OX22high T cells in mercury-induced autoimmunity in the brown Norway rat. J Exp Med. 1993 May 1;177(5):1309-16. The monoclonal antibody OX22 defines a functional split within CD4+ T cells in the rat, with OX22high cells mainly producing interleukin 2 (IL-2) and interferon gamma and responsible for delayed-type hypersensitivity responses, and OX22low cells mainly producing IL-4 and -5 and responsible for providing B cell help. We have used OX22 in vivo to define the role of these subsets in mercuric chloride-induced autoimmunity in the Brown Norway rat. |
1(0,0,0,1) | Details |
| 18432732 | Badou A, Saoudi A, Dietrich G, Druet E, Druet P, Pelletier L: Mercuric chloride-induced autoimmunity. Curr Protoc Immunol. 2001 May;Chapter 15:Unit 15.15. Also covered are disease induction using autoreactive CD4 (+) T (H) 2 anti-self MHC class II molecules and preparation of T cell lines. |
1(0,0,0,1) | Details |
| 9409645 | Loftenius A, Ekstrand J, Moller E: In vitro effects of mercuric chloride (HgCl2) on human mononuclear cells. . Clin Exp Immunol. 1997 Dec;110(3):418-22. It is found that HgCl2 in a narrow concentration range has the ability to preferentially stimulate the CD4+ T cell subset to blast transformation and DNA synthesis. |
1(0,0,0,1) | Details |
| 7589090 | Kiely PD, Gillespie KM, Oliveira DB: Oxpentifylline inhibits tumor necrosis factor-alpha mRNA transcription and protects against arthritis in mercuric chloride-treated brown Norway rats. Eur J Immunol. 1995 Oct;25(10):2899-906. The phosphodiesterase inhibitor oxpentifylline (OXP) has a number of potentially important immunomodulatory actions which include a selective inhibition of the Th1 subset of CD4+ cells in vitro and inhibition of tumor necrosis factor (TNF)-alpha mRNA transcription. |
1(0,0,0,1) | Details |
| 9570334 | Kosuda LL, Whalen B, Greiner DL, Bigazzi PE: Mercury-induced autoimmunity in Brown Norway rats: kinetics of changes in RT6+ T lymphocytes correlated with IgG isotypes of circulating autoantibodies to laminin 1. Toxicology. 1998 Feb 6;125(2-3):215-31. We have also observed a significant percent decrease in CD4+ T lymphocytes as well as an increase in CD4-CD8- cells. |
1(0,0,0,1) | Details |
| 9388500 | Roos A, Claessen N, Schilder-Tol EJ, Chand MA, Weening JJ, Aten J: Thiol levels in CD134-defined subsets of rat T lymphocytes: possible implications for HgCl2-induced immune dysregulation. Biochem Biophys Res Commun. 1997 Nov 17;240(2):452-7. Strain-dependent differences in thiol levels in CD134-defined subsets of CD4+ lymphocytes and subset-specific modification of thiol levels may contribute to differential lymphocyte activation by oxidizing chemicals. |
1(0,0,0,1) | Details |
| 2139074 | Tournade H, Pelletier L, Pasquier R, Vial MC, Mandet C, Druet P: D-penicillamine-induced autoimmunity in Brown-Norway rats. J Immunol. 1990 Apr 15;144(8):2985-91. These manifestations are quite similar to those observed in mercuric chloride (HgCl2)-induced autoimmunity. A transient increase in the number of spleen cells, affecting B cells and CD4+ T cells, and an increase in serum IgE concentration, previously reported in HgCl2-induced autoimmunity, were observed during DP treatment. |
1(0,0,0,1) | Details |
| 11007765 | Field AC, Caccavelli L, Fillion J, Kuhn J, Mandet C, Druet P, Bellon B: Neonatal induction of tolerance to T (h) 2-mediated autoimmunity in rats. Int Immunol. 2000 Oct;12(10):1467-77. Brown-Norway (BN) rats are highly susceptible to drug-induced immune dysregulations and when injected with mercuric chloride (HgCl (2)) or aurothiopropanolsulfonate (ATPS), they develop a syndrome characterized by a polyclonal B cell activation depending upon CD4 (+) T (h) 2 cells that recognize self-MHC class II molecules. |
81(1,1,1,1) | Details |
| 1716519 | Rossert J, Pelletier L, Pasquier R, Villarroya H, Oriol R, Druet P: HgCl2-induced perturbation of the T cell network in experimental allergic encephalomyelitis. Cell Immunol. 1991 Oct 15;137(2):367-78. Mercuric chloride (HgCl2) induces in Lewis (LEW) rats a non-antigen-specific immunosuppression and is able to down-modulate experimental allergic encephalomyelitis in about 70% of the rats. These cells, which could act as contrasuppressor cells, were CD4+ and adhered to Vicia villosa lectin; their frequency was in the same range as that of T helper cells. |
1(0,0,0,1) | Details |
| 8871763 | Kosuda LL, Hannigan MO, Bigazzi PE, Leif JH, Greiner DL: Thymus atrophy and changes in thymocyte subpopulations of BN rats with mercury-induced renal autoimmune disease. Autoimmunity. 1996;23(2):77-89. Absolute increases in the number of CD4+ single-positive thymocytes were also observed. |
1(0,0,0,1) | Details |
| 8296602 | Qasim FJ, Mathieson PW, Thiru S, Oliveira DB, Lockwood CM: Further characterization of an animal model of systemic vasculitis. . Adv Exp Med Biol. 1993;336:133-7. We describe some preliminary experiments on the effect of transfer of serum from mercuric chloride treated rats and of two forms of immunotherapy: intravenous immunoglobulin and an anti-CD4 antibody. |
31(0,1,1,1) | Details |
| 8918574 | Kiely PD, O'Brien D, Oliveira DB: Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity. Clin Exp Immunol. 1996 Nov;106(2):280-5. Mercuric chloride (HgCl2) induces a T cell-dependent autoimmune syndrome in Brown-Norway (BN) rats characterized by a humoral response, tissue injury with an accumulation of CD8+ and CD4+ T cells, and an increase in tissue IL-4 mRNA and serum IgE suggesting Th2 cell activation. |
31(0,1,1,1) | Details |
| 2009908 | Aten J, Veninga A, De Heer E, Rozing J, Nieuwenhuis P, Hoedemaeker PJ, Weening JJ: Susceptibility to the induction of either autoimmunity or immunosuppression by mercuric chloride is related to the major histocompatibility complex class II haplotype. Eur J Immunol. 1991 Mar;21(3):611-6. Mercuric chloride (HgCl2) induces in Brown Norway rats a CD4+ T lymphocyte-dependent systemic autoimmune syndrome, involving synthesis of anti-glomerular basement membrane autoantibodies and development of proteinuria. |
31(0,1,1,1) | Details |
| 1572095 | Lillevang ST, Rosenkvist J, Andersen CB, Larsen S, Kemp E, Kristensen T: Single and combined effects of the analogue KH1060 and cyclosporin A on mercuric-chloride-induced autoimmune disease in the BN rat. Clin Exp Immunol. 1992 May;88(2):301-6. Mercuric chloride induces in BN rats a self-limiting systemic autoimmune disease characterized by proliferation of autoreactive CD4+ T lymphocytes, polyclonal activation of B lymphocytes, and the development of an anti-glomerular basement membrane (GBM) nephritis with concomitant nephrotic range proteinuria. |
31(0,1,1,1) | Details |
| 8633208 | Roos A, Claessen N, Weening JJ, Aten J: Enhanced T lymphocyte expression of LFA-1, ICAM-1, and the TNF receptor family member OX40 in HgCl2-induced systemic autoimmunity. Scand J Immunol. 1996 May;43(5):507-18. Injection of mercuric chloride into Brown Norway (BN) rats induces a T lymphocyte-dependent autoimmune syndrome. Tri-colour flow cytometry was performed for expression analysis within CD45RC-defined subsets of CD4+ and CD8+ cells. |
5(0,0,0,5) | Details |
| 10529590 | Loftenius A, Ekstrand J, Moller E: HgCl (2)-induced human lymphocyte activation in vitro: a superantigenic mechanism?. Int Arch Allergy Immunol. 1999 Sep;120(1):63-70. Mercuric chloride (HgCl (2)) has been proposed to be a mitogen for human blood lymphocytes in vitro. In our previous study, we demonstrated that HgCl (2) preferentially stimulates the CD4+ T cell subset to blast transformation and DNA synthesis and that the reaction is dependent on CD14+ accessory cells. |
4(0,0,0,4) | Details |
| 15036746 | Mellergard J, Havarinasab S, Hultman P: Short- and long-term effects of T-cell modulating agents in experimental autoimmunity. Toxicology. 2004 Mar 15;196(3):197-209. Three weeks initial treatment with cyclosporin A (CyA), a high dose of tacrolimus (HD tacrolimus), or anti-CD4 monoclonal antibody (a-CD4) inhibited induction of ANoA and IC deposit by Hg. |
3(0,0,0,3) | Details |
| 7897203 | Jiang Y, Moller G: In vitro effects of HgCl2 on murine lymphocytes. J Immunol. 1995 Apr 1;154(7):3138-46. Preferable activation of CD4+ T cells in a responder strain.. |
3(0,0,0,3) | Details |
| 8096239 | Castedo M, Pelletier L, Rossert J, Pasquier R, Villarroya H, Druet P: Mercury-induced autoreactive anti-class II T cell line protects from experimental autoimmune encephalomyelitis by the bias of CD8+ antiergotypic cells in Lewis rats. J Exp Med. 1993 Apr 1;177(4):881-9. In the present study, we show that CD4+ anti-class II T cells are present in HgCl2-injected LEW rats and are as frequent as in BN rats when assessed by limiting dilution analysis. |
3(0,0,0,3) | Details |
| 1832585 | Pelletier L, Rossert J, Pasquier R, Villarroya H, Oriol R, Druet P: HgCl2-induced perturbation of the T cell network in experimental allergic encephalomyelitis. Cell Immunol. 1991 Oct 15;137(2):379-88. Immunol. 137, 1991), we showed by using limiting dilution analysis that Lewis (LEW) rats injected with HgCl2 and immunized with myelin (LEWHg/MYE) exhibit anti-basic protein CD4+ T helper cells (Th), at least 10-fold more frequent CD8+ T suppressor cells (Ts), and T contrasuppressor cells (Tcs). |
3(0,0,0,3) | Details |
| 7647579 | Kubicka-Muranyi M, Griem P, Lubben B, Rottmann N, Luhrmann R, Gleichmann E: Mercuric-chloride-induced autoimmunity in mice involves up-regulated presentation by spleen cells of altered and unaltered nucleolar self antigen. Int Arch Allergy Immunol. 1995 Sep;108(1):1-10. Of nine CD4+ T cell hybridoma clones obtained from HgCl2-treated B10.S mice, one clone reacted to histone Hl and eight clones to fibrillarin. |
2(0,0,0,2) | Details |
| 3052091 | Aten J, Bosman CB, Rozing J, Stijnen T, Hoedemaeker PJ, Weening JJ: Mercuric chloride-induced autoimmunity in the brown Norway rat. Am J Pathol. 1988 Oct;133(1):127-38. An early increase of CD4+ splenocytes was followed by a transient proliferation of CD4+ as well as CD8+ and B lymphocytes in peripheral lymphoid organs; in contrast, progressive depletion of the thymic cortex was found. |
2(0,0,0,2) | Details |
| 7704901 | van der Meide PH, Groenestein RJ, de Labie MC, Aten J, Weening JJ: Susceptibility to mercuric chloride-induced glomerulonephritis is age-dependent: study of the role of IFN-gamma. Cell Immunol. 1995 Apr 15;162(1):131-7. Data have been presented suggesting that during disease development there is a preferential expansion of CD4+ T cells belonging to the TH2 subset. |
2(0,0,0,2) | Details |
| 9565363 | Albers R, de Heer C, Bol M, Bleumink R, Seinen W, Pieters R: Selective immunomodulation by the autoimmunity-inducing xenobiotics streptozotocin and HgCl2. Eur J Immunol. 1998 Apr;28(4):1233-42. A single injection of streptozotocin (STZ) increased the number of CD8+ cells, macrophages, apoptotic cells, and IFN-gamma-producing T helper and T cytotoxic cells, whereas the number of CD4+ cells and B cells was reduced in the draining lymph node. |
2(0,0,0,2) | Details |
| 8527945 | Kubicka-Muranyi M, Kremer J, Rottmann N, Lubben B, Albers R, Bloksma N, Luhrmann R, Gleichmann E: Murine systemic autoimmune disease induced by mercuric chloride: T helper cells reacting to self proteins. Int Arch Allergy Immunol. 1996 Jan;109(1):11-20. HgCl2 induces a CD4+ T-cell-dependent systemic autoimmune disease in susceptible strains of rats and mice. |
1(0,0,0,1) | Details |
| 9237798 | Johansson U, Sander B, Hultman P: Effects of the murine genotype on T cell activation and cytokine production in murine mercury-induced autoimmunity. J Autoimmun. 1997 Aug;10(4):347-55. This was followed by a long-lasting increase in the number of T cells, dominated by CD4 (+) cells. |
1(0,0,0,1) | Details |
| 8388693 | Mathieson PW, Qasim FJ, Esnault VL, Oliveira DB: Animal models of systemic vasculitis. . J Autoimmun. 1993 Apr;6(2):251-64. We have recently reported that Brown Norway rats treated with mercuric chloride (HgCl2) develop necrotizing leucocytoclastic vasculitis, especially in the gut, and also develop antibodies to myeloperoxidase (MPO) which recognize similar determinants on MPO to those bound by a subset of ANCA. |
0(0,0,0,0) | Details |
| 18958740 | Pilones K, Lai ZW, Gavalchin J: Prenatal HgCl (2) Exposure Alters Fetal Cell Phenotypes. J Immunotoxicol. 2007 Oct;4(4):295-301. After overnight breeding of female BALB/c and male DBA/1 mice, pregnant females were exposed to 10 mg/l mercuric chloride in drinking water. |
0(0,0,0,0) | Details |
| 19678760 | Pilones K, Tatum A, Gavalchin J: Gestational exposure to mercury leads to persistent changes in T-cell phenotype and function in adult DBF1 mice. J Immunotoxicol. 2009 Sep;6(3):161-70. After overnight breeding to DBA/1 males, pregnant BALB/c dams were given either mercuric chloride in drinking water at 10 mg/L ad libitum for the duration of gestation or plain water. |
0(0,0,0,0) | Details |