| Name | metallothionein (protein family or complex) |
|---|---|
| Synonyms | Metallothionein; Metallothioneins |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18723121 | Faria M, Carrasco L, Diez S, Riva MC, Bayona JM, Barata C: Multi-biomarker responses in the freshwater mussel Dreissena polymorpha exposed to polychlorobiphenyls and metals. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Apr;149(3):281-8. Epub 2008 Aug 3. Behavioral and biochemical responses including filtering rates, key phase I, II and antioxidant enzymes and levels of metallothioneins, lipid peroxidation and DNA strand breaks were determined in digestive glands of mussels after being exposed to sublethal levels of mercury methyl mercury, cadmium and Aroclor 1260 during 5 days. |
3(0,0,0,3) | Details |
| 11346487 | Tandon SK, Singh S, Prasad S, Mathur N: Hepatic and renal metallothionein induction by an oral equimolar dose of zinc, cadmium or mercury in mice. Food Chem Toxicol. 2001 Jun;39(6):571-7. The accumulation of mercury in kidney was 1.5 times that in liver, which was localised more in their SCF than in their NMF at 24 h in response to a dose of mercuric chloride. |
2(0,0,0,2) | Details |
| 2461259 | Koizumi T, Yamane Y: Protective effect of on the acute toxicity of mercuric chloride. Chem Biol Interact. 1988;67(3-4):185-97. Sephadex G-75 gel filtration showed that the increase in mercury content in the cytosol of Na2MoO4-pretreated rats is due to an increase in the metal content of a metallothionein-like fraction. |
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| 9015156 | Rossman TG, Goncharova EI, Nadas A, Dolzhanskaya N: Chinese hamster cells expressing antisense to metallothionein become spontaneous mutators. Mutat Res. 1997 Jan 3;373(1):75-85. |
2(0,0,0,2) | Details |
| 12490134 | Jin GB, Inoue S, Urano T, Cho S, Ouchi Y, Cyong JC: Induction of anti-metallothionein antibody and mercury treatment decreases bone mineral density in mice. Toxicol Appl Pharmacol. 2002 Dec 1;185(2):98-110. Mercuric chloride (HgCl2) is an industrial agent with toxic effects on the immune system, kidney, lung, and nervous tissue, but little is known about its effect on bone. |
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| 20229497 | Agarwal R, Goel SK, Behari JR: Detoxification and antioxidant effects of in rats experimentally exposed to mercury. J Appl Toxicol. 2010 Mar 12. Therefore, the detoxification and antioxidant effects of were examined to determine its prophylactic/therapeutic role in rats experimentally exposed to mercury (in the from of mercuric chloride-HgCl (2), 12 micromol kg (-1) b.w. single intraperitoneal injection). Mercury exposure resulted in the induction of metallothionein (MT) mRNA expressions in the liver and kidney. |
2(0,0,0,2) | Details |
| 15795095 | Beattie JH, Owen HL, Wallace SM, Arthur JR, Kwun IS, Hawksworth GM, Wallace HM: Metallothionein overexpression and resistance to toxic stress. Toxicol Lett. 2005 May 16;157(1):69-78. In contrast, overexpression of MT afforded no protection against mercuric chloride, staurosporine and peroxide (IC50 values of about 50, 11 and 925 microM, respectively). |
2(0,0,0,2) | Details |
| 9817076 | Rodilla V, Miles AT, Jenner W, Hawksworth GM: Exposure of cultured human proximal tubular cells to cadmium, mercury, zinc and bismuth: toxicity and metallothionein induction. Chem Biol Interact. 1998 Aug 14;115(1):71-83. |
2(0,0,0,2) | Details |
| 16395915 | Shen JC, Huang ZY, Zhuang ZX, Wang XR, Frank LS: [Study on Hg2+ distribution and speciation in different tissues of rats] . Guang Pu Xue Yu Guang Pu Fen Xi. 2005 Oct;25(10):1688-92. The purpose of this paper was to determine mercury distribution and mercury binding proteins in different tissues of rat fed orally with mercuric chloride by ICP-MS and SEC-UV-ICP-MS. The result showed that liver and kidney induced large amount of metallothioneins that was found to bind to mercury, and zinc after mercury intake in stomach and intestines. |
2(0,0,0,2) | Details |
| 11606802 | DeMoor JM, Kennette WA, Collins OM, Koropatnick J: -metallothionein levels are correlated with enhanced glucocorticoid responsiveness in mouse cells exposed to ZnCl (2), HgCl (2), and heat shock. Toxicol Sci. 2001 Nov;64(1):67-76. |
2(0,0,0,2) | Details |
| 11370844 | Shishido N, Nakayama K, Takazawa A, Ohyama T, Nakamura M: Cu-metallothioneins (Cu (I) 8-MTs) in LEC rat livers 13 weeks after birth still act as antioxidants. Arch Biochem Biophys. 2001 Mar 15;387(2):216-22. |
2(0,0,0,2) | Details |
| 8696073 | Morcillo MA, Santamaria J: Mercury distribution and renal metallothionein induction after subchronic oral exposure in rats. Biometals. 1996 Jul;9(3):213-20. The animals were exposed to mercuric chloride labelled with 203Hg via drinking water for 8 weeks (5, 50 and 500 microM Hg). |
2(0,0,0,2) | Details |
| 7823324 | Zalups RK, Cherian MG, Barfuss DW: Lack of luminal or basolateral uptake and transepithelial transport of mercury in isolated perfused proximal tubules exposed to mercury-metallothionein. J Toxicol Environ Health. 1995 Jan;44(1):101-13. |
2(0,0,0,2) | Details |
| 16964587 | Brandao R, Santos FW, Farina M, Zeni G, Bohrer D, Rocha JB, Nogueira CW: Antioxidants and metallothionein levels in mercury-treated mice. Cell Biol Toxicol. 2006 Nov;22(6):429-38. Epub 2006 Sep 11. Mice received a single dose of mercuric chloride (HgCl2, 4.6 mg/kg, subcutaneously) for three consecutive days. |
2(0,0,0,2) | Details |
| 17916369 | Peixoto NC, Serafim MA, Flores EM, Bebianno MJ, Pereira ME: Metallothionein, zinc, and mercury levels in tissues of young rats exposed to zinc and subsequently to mercury. Life Sci. 2007 Sep 29;81(16):1264-71. Epub 2007 Sep 16. |
2(0,0,0,2) | Details |
| 1794859 | Dalal R, Bhattacharya S: Effect of chronic non-lethal doses of non-metals and metals on hepatic metallothionein in Channa punctatus (Bloch). Indian J Exp Biol. 1991 Jul;29(7):693-4. |
2(0,0,0,2) | Details |
| 11077005 | Schurz F, Sabater-Vilar M, Fink-Gremmels J: Mutagenicity of mercury and mechanisms of cellular defence: the role of metal-binding proteins. Mutagenesis. 2000 Nov;15(6):525-30. This induction of oxidative stress was observed, although the intracellular (GSH) and metallothionein (MT) concentrations were increased significantly. |
1(0,0,0,1) | Details |
| 19747521 | Stacchiotti A, Li Volti G, Lavazza A, Rezzani R, Rodella LF: Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chloride. Food Chem Toxicol. 2009 Nov;47(11):2834-40. Epub 2009 Sep 9. Heat shock proteins (HSP) and metallothioneins (MTs) help to protect cells against metal toxicity. |
1(0,0,0,1) | Details |
| 3193255 | Jaw S, Jeffery EH: The effect of dietary zinc status on biliary metal excretion of rats. J Nutr. 1988 Nov;118(11):1385-90. Hepatic metallothionein (MT) was similar in low- and adequate-zinc groups, but was 18-fold higher in the high-zinc group than in the other two groups. |
1(0,0,0,1) | Details |
| 14615064 | Peixoto NC, Roza T, Flores EM, Pereira ME: Effects of zinc and cadmium on HgCl2-delta-ALA-D inhibition and Hg levels in tissues of suckling rats. Toxicol Lett. 2003 Dec 15;146(1):17-25. In face of zinc effects to prevent Hg-delta-ALA-D inhibition and to alter Hg-deposition levels in kidney and liver, these results suggest that these effects may be partially due to the synthesis of metallothioneins (MT). |
1(0,0,0,1) | Details |
| 19501138 | Piacenza F, Malavolta M, Cipriano C, Costarelli L, Giacconi R, Muti E, Tesei S, Pierpaoli S, Basso A, Bracci M, Bonacucina V, Santarelli L, Mocchegiani E: normalizes NOS activity and zinc-MT homeostasis in the kidney of mice chronically exposed to inorganic mercury. Toxicol Lett. 2009 Sep 28;189(3):200-5. Epub 2009 Jun 6. Inducible synthase (iNOS) expression, total NOS activity and the profiles of zinc (Zn), (Cu) and Hg as well as their distribution when bound to specific intracellular proteins, including metallothioneins (MT), were studied during HgCl2 exposure and after treatment in C57BL/6 mouse kidney. |
1(0,0,0,1) | Details |
| 2353358 | Beattie JH, Marion M, Schmit JP, Denizeau F: The cytotoxic effects of cadmium and mercuric chloride mixtures in rat primary hepatocyte cultures. Toxicology. 1990 May 31;62(2):161-73. Gel chromatography of the cytosol from Cd-exposed cells showed 3 Cd containing fractions which corresponded to the elution positions of high Mr proteins, metallothionein (MT) and low Mr molecules. |
1(0,0,0,1) | Details |
| 19720107 | Stacchiotti A, Morandini F, Bettoni F, Schena I, Lavazza A, Grigolato PG, Apostoli P, Rezzani R, Aleo MF: Stress proteins and oxidative damage in a renal derived cell line exposed to inorganic mercury and lead. Toxicology. 2009 Oct 29;264(3):215-24. Epub 2009 Aug 29. Here we analysed the time course of the expression of several heat shock proteins, -regulated proteins and metallothioneins in a rat proximal tubular cell line (NRK-52E) exposed to subcytotoxic doses of inorganic mercury and lead. |
1(0,0,0,1) | Details |
| 19636703 | Monteiro DA, Rantin FT, Kalinin AL: Inorganic mercury exposure: toxicological effects, oxidative stress biomarkers and bioaccumulation in the tropical freshwater fish matrinxa, Brycon amazonicus (Spix and Agassiz, 1829). Ecotoxicology. 2010 Jan;19(1):105-23. Epub 2009 Jul 28. Metallothionein concentrations were significantly high after HgCl (2) exposure in the liver, gills and heart, but remained at control values in the white muscle. |
1(0,0,0,1) | Details |
| 12911155 | Levine S, Saltzman A: Acute uremia produced in rats by nephrotoxic chemicals is alleviated by protein deficient diet. Ren Fail. 2003 Jul;25(4):517-23. Rats injected with mercuric chloride develop an acute renal tubular necrosis with uremia, which is frequently lethal. Indirect evidence suggests that induction of metallothionein may be involved, at least in the experiments with mercury. |
1(0,0,0,1) | Details |
| 3358258 | Houser MT, Berndt WO: Unilateral nephrectomy in the rat: effects on mercury handling and renal cortical subcellular distribution. Toxicol Appl Pharmacol. 1988 Apr;93(2):187-94. As unilateral nephrectomy (UNX) is associated with enhanced mercuric chloride nephrotoxicity, studies were undertaken to characterize the effects of UNX on the tissue content, urinary excretion, and renal cortical subcellular distribution of mercury in the rat. Subcellular distribution studies demonstrated that cytosolic mercury was uniformly elevated in all UNX groups at 1, 3, and 24 hr following injection while mercury bound to "metallothionein-like" proteins or free in the cytosol was increased only at 1 or 3 hr. |
1(0,0,0,1) | Details |
| 3338102 | Kroll DJ, Graichen ME, Leonard TB: Strain difference in rat renal microsomal epoxide hydrolase elevation after mercuric chloride treatment. Carcinogenesis. 1988 Feb;9(2):193-8. Hepatic metallothionein (MT) concentrations were increased at 1 day to 300% and 400% of control in F344 and SD rats, respectively. |
1(0,0,0,1) | Details |
| 16801527 | Stacchiotti A, Ricci F, Rezzani R, Li Volti G, Borsani E, Lavazza A, Bianchi R, Rodella LF: Tubular stress proteins and synthase expression in rat kidney exposed to mercuric chloride and J Histochem Cytochem. 2006 Oct;54(10):1149-57. Epub 2006 Jun 26. Stress proteins such as HSP70 members (HSP72 and GRP75) and metallothionein (MT) protect the kidney against oxidative damage and harmful metals, whereas inducible synthase (iNOS) regulates tubular functions. |
1(0,0,0,1) | Details |
| 9585089 | Sugawara N, Lai YR, Sugaware C, Arizono K: Decreased hepatobiliary secretion of inorganic mercury, its deposition and toxicity in the Eisai hyperbilirubinemic rat with no hepatic canalicular organic anion transporter. Toxicology. 1998 Feb 20;126(1):23-31. The increased retention stimulated hepatic metallothionein (MT) induction and increased the proportion of Hg in the MT region on the Sephadex column. |
1(0,0,0,1) | Details |
| 9358058 | Fujii M, Saijoh K, Kobayashi T, Fujii S, Lee MJ, Sumino K: Analysis of bovine selenoprotein P-like protein gene and availability of metal responsive element (MRE) located in its promoter. Gene. 1997 Oct 15;199(1-2):211-7. Metallothionein mRNA markedly increased 6 h after administration of 10 (-6) M CdCl2 and ZnCl2 in both cell lines. |
1(0,0,0,1) | Details |
| 11356909 | Bartosiewicz MJ, Jenkins D, Penn S, Emery J, Buckpitt A: Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants. J Pharmacol Exp Ther. 2001 Jun;297(3):895-905. Both peroxisome proliferators up-regulated Cyp4a10, acyl-CoA thioesterase, and insulin-like growth factor binding protein-1, whereas the DNA alkylators altered the expression of monokine induced by gamma-interferon, the metallothioneins, p21, and several acute phase proteins. |
1(0,0,0,1) | Details |
| 1866389 | Liu XY, Jin TY, Nordberg GF: Increased urinary and excretion in rats injected with mercuric chloride. Pharmacol Toxicol. 1991 Apr;68(4):254-9. In this study, metallothionein (MT), as well as (Na) and (K) in urine, kidney cortex and liver were measured in male Wistar rats after two daily injections of HgCl2 (0.5 or 1.0 mg Hg/kg body weight intraperitoneally). |
1(0,0,0,1) | Details |
| 10433380 | Chapman LA, Chan HM: Inorganic mercury pre-exposures protect against methyl mercury toxicity in NSC-34 (neuron x spinal cord hybrid) cells. Toxicology. 1999 Feb 15;132(2-3):167-78. To mimic the increase in Hg2+ in the mammalian brain with long term MeHg exposure, the cells were treated with 1 microM mercuric chloride (HgCl2) for five passages before exposure to MeHgCl (1-16 microM) for 48 h. |
0(0,0,0,0) | Details |
| 8248951 | Zalups RK, Cherian MG, Barfuss DW: Mercury-metallothionein and the renal accumulation and handling of mercury. Toxicology. 1993 Oct 25;83(1-3):61-78. In the present study, we evaluated the renal and hepatic accumulation of mercury, the intrarenal distribution of mercury and the urinary and fecal excretion of mercury in rats injected intravenously with a non-toxic 0.1 mumol/kg-dose of mercury in the form of mercuric chloride (HgCl2) or a complex of mercury-metallothionein (Hg-MT). |
83(1,1,1,3) | Details |
| 8784822 | Aschner M, Rising L, Mullaney KJ: Differential sensitivity of neonatal rat astrocyte cultures to mercuric chloride (MC) and methylmercury (MeHg): studies on K+ and amino acid transport and metallothionein (MT) induction. Neurotoxicology. 1996 Spring;17(1):107-16. |
82(1,1,1,2) | Details |
| 1729771 | Zalups RK, Cherian MG: Renal metallothionein metabolism after a reduction of renal mass. Toxicology. 1992;71(1-2):83-102. |
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| 9400030 | Satoh M, Nishimura N, Kanayama Y, Naganuma A, Suzuki T, Tohyama C: Enhanced renal toxicity by inorganic mercury in metallothionein-null mice. J Pharmacol Exp Ther. 1997 Dec;283(3):1529-33. To elucidate a protective role of metallothionein (MT) in the manifestation of inorganic mercury toxicity, we studied the susceptibility of MT-null mice to the renal toxicity of mercuric chloride. |
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| 12815612 | Reus IS, Bando I, Andres D, Cascales M: Relationship between expression of HSP70 and metallothionein and oxidative stress during mercury induced acute liver injury in rats. J Biochem Mol Toxicol. 2003;17(3):161-8. |
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| 1729759 | Zalups RK, Cherian MG: Renal metallothionein metabolism after a reduction of renal mass. Toxicology. 1992;71(1-2):103-17. |
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| 1392467 | Liu X, Nordberg GF, Jin T: Increased urinary excretion of zinc and by mercuric chloride injection in rats. Biometals. 1992 Spring;5(1):17-22. The effects of HgCl2 on urinary excretion of Zn, Cu and metallothionein at different time intervals were observed in male Wistar rats. |
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| 2272651 | Agrawal A, Bhattacharya S: Purification of a metallothionein-like protein from serum of mercury-treated rats using -Sepharose affinity column. Indian J Exp Biol. 1990 Jul;28(7):648-52. |
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