Protein Information

Name interleukin 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
16428073 Santarelli L, Bracci M, Mocchegiani E: In vitro and in vivo effects of mercuric chloride on thymic endocrine activity, NK and NKT cell cytotoxicity, cytokine profiles (IL-2, IFN-gamma, IL-6): role of the nitric oxide-L-arginine pathway. Int Immunopharmacol. 2006 Mar;6(3):376-89. Epub 2005 Nov 9.
8(0,0,1,3) Details
19539721 Chang JY, Tsai PF: IL-6 release from mouse glia caused by MeHg requires cytosolic phospholipase A2 activation. Neurosci Lett. 2009 Sep 18;461(2):85-9. Epub 2009 Jun 17.

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20222982 Kempuraj D, Asadi S, Zhang B, Manola A, Hogan J, Peterson E, Theoharides TC: Mercury induces inflammatory mediator release from human mast cells. . J Neuroinflammation. 2010 Mar 11;7(1):20.

We, therefore, investigated the effect of mercuric chloride (HgCl2) on human mast cell activation.
METHODS: Human leukemic cultured LAD2 mast cells and normal human umbilical cord blood-derived cultured mast cells (hCBMCs) were stimulated by HgCl2 (0.1-10 microM) for either 10 min for beta-hexosaminidase release or 24 h for measuring vascular endothelial growth factor (VEGF) and IL-6 release by ELISA.
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17302730 Hemdan NY, Lehmann I, Wichmann G, Lehmann J, Emmrich F, Sack U: Immunomodulation by mercuric chloride in vitro: application of different cell activation pathways. Clin Exp Immunol. 2007 May;148(2):325-37. Epub 2007 Feb 14.

In MoAb-stimulated cells, interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 production was reduced.
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8898950 Gillespie KM, Saoudi A, Kuhn J, Whittle CJ, Druet P, Bellon B, Mathieson PW: Th1/Th2 cytokine gene expression after mercuric chloride in susceptible and resistant rat strains. Eur J Immunol. 1996 Oct;26(10):2388-92.

Semiquantitative PCR showed increased expression of IL-2, IL-6 and IL-10 in BN; in LEW rats only IL-10 was increased.
1(0,0,0,1) Details