Protein Information

Name CD40
Synonyms B cell associated molecule CD40; p50; B cell surface antigen CD40; Bp50; CD40; CD40 antigen isoform 1; CD40 antigen isoform 1 precursor; CD40L receptor…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
15494542 Pollard KM, Arnush M, Hultman P, Kono DH: Costimulation requirements of induced murine systemic autoimmune disease. . J Immunol. 2004 Nov 1;173(9):5880-7.


A number of receptor/ligand pairs have been shown to mediate costimulation, including CD28/B7 molecules (CD80 and CD86), CD40/CD40 ligand (CD40L, CD154), and LFA-1 (CD18)/ICAM-1 (CD54).
2(0,0,0,2) Details
8666905 Biancone L, Andres G, Ahn H, Lim A, Dai C, Noelle R, Yagita H, De Martino C, Stamenkovic I: Distinct regulatory roles of lymphocyte costimulatory pathways on T helper type-2 mediated autoimmune disease. J Exp Med. 1996 Apr 1;183(4):1473-81.


We assessed the role of CD40-CD40L, cytotoxic T lymphocyte (CTL) A4/CD28-B7s, and CD2-CD48/CD58 lymphocyte costimulatory pathways in the development of mercury chloride (HgCl2)-induced autoimmune disease in mice, which is believed to be mediated by T helper (Th) subset Th2.
2(0,0,0,2) Details
17302730 Hemdan NY, Lehmann I, Wichmann G, Lehmann J, Emmrich F, Sack U: Immunomodulation by mercuric chloride in vitro: application of different cell activation pathways. Clin Exp Immunol. 2007 May;148(2):325-37. Epub 2007 Feb 14.

Human cell cultures were set up where isolated peripheral blood mononuclear cells, activated by monoclonal antibodies (MoAb: anti-CD3/-CD28/-CD40) or heat-killed Salmonella enterica serovar Enteritidis (hk-SE), exposed to mercuric chloride (HgCl2) for 24 h.
31(0,1,1,1) Details