Protein Information

Name TNFalpha
Synonyms Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
7589090 Kiely PD, Gillespie KM, Oliveira DB: Oxpentifylline inhibits tumor necrosis factor-alpha mRNA transcription and protects against arthritis in mercuric chloride-treated brown Norway rats. Eur J Immunol. 1995 Oct;25(10):2899-906.
32(0,1,1,2) Details
18475678 Molina A, Sanchez-Madrid F, Bricio T, Martin A, Escudero E, Alvarez V, Mampaso F: Abrogation of mercuric chloride-induced nephritis in the Brown Norway rat by treatment with antibodies against TNFalpha. Mediators Inflamm. 1995;4(6):444-51.
6(0,0,1,1) Details
19404869 Zefferino R, Leone A, Piccaluga S, Cincione R, Ambrosi L: Mercury modulates interplay between IL-1beta, TNF-alpha, and gap junctional intercellular communication in keratinocytes: mitigation by lycopene. J Immunotoxicol. 2008 Oct;5(4):353-60.


Specifically, TNFalpha and IL-1beta are important for initiating/augmenting CD8 (+)- and NK-cell mediated killing; however, in what appears counterintuitive, each--at times--can act to protect cancer cells against apoptosis, a major mechanism for cell killing from within.
3(0,0,0,3) Details
15986368 Pacheco FJ, Servin J, Dang D, Kim J, Molinaro C, Daniels T, Brown-Bryan TA, Imoto-Egami M, Casiano CA: Involvement of lysosomal cathepsins in the cleavage of DNA topoisomerase I during necrotic cell death. Arthritis Rheum. 2005 Jul;52(7):2133-45.


METHODS: Topo I cleavage during necrosis was assessed by immunoblotting of lysates from L929 fibroblasts exposed to tumor necrosis factor alpha (TNFalpha) and the broad caspase inhibitor Z-VAD-FMK, and by immunoblotting of lysates from endothelial cells treated with HgCl2.
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15050407 Kim SH, Sharma RP: Mercury-induced apoptosis and necrosis in murine macrophages: role of calcium-induced reactive oxygen species and p38 mitogen-activated protein kinase signaling. Toxicol Appl Pharmacol. 2004 Apr 1;196(1):47-57.

The cytotoxic EC (50) of mercury ranged from 62.7 to 81.1 microM by various assays in J774A.1 cultures; accordingly, we employed 70 microM of mercuric chloride in most experiments.
Mercury increased the expression of tumor necrosis factor alpha (TNFalpha); antioxidants and a specific p38 inhibitor decreased this effect.
2(0,0,0,2) Details
9853001 Yanagisawa H, Nodera M, Umemori Y, Shimoguchi Y, Wada O: Role of angiotensin II, endothelin-1, and nitric oxide in HgCl2-induced acute renal failure. Toxicol Appl Pharmacol. 1998 Oct;152(2):315-26.


To elucidate the mechanisms underlying the development of HgCl2-induced acute renal failure (ARF), we examined the expression of endothelin (ET)-1, endothelial (e) nitric oxide synthase (NOS) and inducible (i) NOS, and a role of angiotensin II (ANG II) and tumor necrosis factor (TNF) in glomeruli and cortices from rats at 20 h after exposure of HgCl2.
1(0,0,0,1) Details
11912253 Nieto E, Escudero E, Navarro E, Yanez-Mo M, Martin A, Perez de Lema G, Sanchez-Madrid F, Mampaso F: Effects of mycophenolate mofetil in mercury-induced autoimmune nephritis. . J Am Soc Nephrol. 2002 Apr;13(4):937-45.


Also, MMF administration to mercury-injected rats reduces the secretion of the proinflammatory cytokine tumor necrosis factor-alpha.
1(0,0,0,1) Details
18758054 Ghosh A, Sil PC: A protein from Cajanus indicus Spreng protects liver and kidney against mercuric chloride-induced oxidative stress. Biol Pharm Bull. 2008 Sep;31(9):1651-8.

In addition, HgCl (2) increased the activities of serum marker enzymes (namely, glutamate pyruvate transaminase, GPT and alkaline phosphatase, ALP), creatinine, blood urea nitrogen and serum tumor necrosis factor alpha (TNF-alpha) level along with hepatic and renal lipid peroxidation.
1(0,0,0,1) Details
17072828 Tunali-Akbay T, Sener G, Salvarli H, Sehirli O, Yarat A: Protective effects of Ginkgo biloba extract against mercury (II)-induced cardiovascular oxidative damage in rats. Phytother Res. 2007 Jan;21(1):26-31.

Rats were injected intraperitoneally with (1) control (C) group: 0.9% NaCl; (2) EGb group: Ginkgo biloba extract (Abdi Ibrahim Pharmaceutical Company, Istanbul, Turkey) at a dose of 50 mg/kg/day; (3) Hg group: a single dose of 5 mg/kg mercuric chloride (HgCl (2)); and (4) Hg + EGb group: First day EGb at a dose of 50 mg/kg/day, i.p., 1 hour after HgCl (2) (5 mg/kg) injection; following four days EGb at a dose 50 mg/kg/day, i.p.
After decapitation of the rats, trunk blood was obtained and serum tumor necrosis factor-alpha (TNF-alpha), lactate dehydrogenase (LDH) activity, and malondialdehyde (MDA) and glutathione (GSH) levels were analysed.
1(0,0,0,1) Details
17267089 Sener G, Sehirli O, Tozan A, Velioglu-Ovunc A, Gedik N, Omurtag GZ: Ginkgo biloba extract protects against mercury (II)-induced oxidative tissue damage in rats. Food Chem Toxicol. 2007 Apr;45(4):543-50. Epub 2006 Aug 30.

Following a single dose of 5mg/kg mercuric chloride (HgCl (2); Hg group) either saline or EGb (150mg/kg) was administered for 5days.
BUN, creatinin, ALT, and AST levels and tumor necrosis factor-alpha (TNF-alpha) and lactate dehydrogenase (LDH) activity were assayed in serum samples.
1(0,0,0,1) Details
20049214 Gardner RM, Nyland JF, Evans SL, Wang SB, Doyle KM, Crainiceanu CM, Silbergeld EK: Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro. Environ Health Perspect. 2009 Dec;117(12):1932-8. Epub 2009 Aug 19.

PBMCs were cultured with lipopolysaccharide and concentrations of mercuric chloride (HgCl (2)) up to 200 nM.
RESULTS: We found a consistent increase in the release of the proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha, and concurrent decrease in release of the antiinflammatory cytokines interleukin 1-receptor antagonist (IL-1Ra) and IL-10 in human PBMCs treated with subcytotoxic concentrations of HgCl (2).
1(0,0,0,1) Details
15226156 Jia Z, Person MD, Dong J, Shen J, Hensley SC, Stevens JL, Monks TJ, Lau SS: Grp78 is essential for 11-deoxy-16,16-dimethyl PGE2-mediated cytoprotection in renal epithelial cells. Am J Physiol Renal Physiol. 2004 Dec;287(6):F1113-22. Epub 2004 Jun 29.


We have now determined the ability of DDM-PGE (2) to protect against other renal toxicants and report that DDM-PGE (2) only protects against oncotic cell death, induced by H (2) O (2), iodoacetamide, and TGHQ, but not against apoptotic cell death induced by cisplatin, mercuric chloride, or tumor necrosis factor-alpha.
0(0,0,0,0) Details