Protein Information

Name calcium channel (protein family or complex)
Synonyms calcium channel

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
8784820 Leonhardt R, Pekel M, Platt B, Haas HL, Busselberg D: Voltage-activated calcium channel currents of rat DRG neurons are reduced by mercuric chloride (HgCl2) and methylmercury (CH3HgCl). Neurotoxicology. 1996 Spring;17(1):85-92.
164(2,2,2,4) Details
9853004 Girardi G, Elias MM: Verapamil protection against mercuric chloride-induced renal glomerular injury in rats. Toxicol Appl Pharmacol. 1998 Oct;152(2):360-5.

We have examined the effects of the calcium channel blocker verapamil on the renal glomerular structural damage produced by mercuric chloride in rats.
6(0,0,1,1) Details
1654000 Blazka ME, Shaikh ZA: Differences in cadmium and mercury uptakes by hepatocytes: role of calcium channels. Toxicol Appl Pharmacol. 1991 Sep 1;110(2):355-63.


Primary cultures of rat hepatocytes were incubated with 3 microM CdCl2 or HgCl2 in the absence or presence of four different organic calcium channel blockers or a calcium agonist.
2(0,0,0,2) Details
19546257 Peltz A, Sherwani SI, Kotha SR, Mazerik JN, O'Connor Butler ES, Kuppusamy ML, Hagele T, Magalang UJ, Kuppusamy P, Marsh CB, Parinandi NL: Calcium and calmodulin regulate mercury-induced phospholipase D activation in vascular endothelial cells. Int J Toxicol. 2009 May-Jun;28(3):190-206.


This study demonstrated the importance of calcium and calmodulin in the regulation of mercury-induced PLD activation and the protective action of L-type calcium channel blockers against mercury cytotoxicity in vascular ECs, suggesting mechanisms of mercury vasculotoxicity and mercury-induced cardiovascular diseases.
1(0,0,0,1) Details
8660137 Girardi G, Elias MM: Evidence for renal ischaemia as a cause of mercuric chloride nephrotoxicity. Arch Toxicol. 1995;69(9):603-7.

Verapamil Vp was used because it was described that calcium channel blockers protect cells from nephrotoxicants and from ischaemia.
1(0,0,0,1) Details