Protein Information

Name epidermal growth factor
Synonyms EGF; Epidermal growth factor; Pro epidermal growth factor; Pro epidermal growth factor precursor; URG; Urogastrone; epidermal growth factor (beta urogastrone); Epidermal growth factors…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
10901180 Hise MK, Liu L, Salmanullah M, Drachenberg CI, Papadimitriou JC, Rohan RM: Mrna expression of transforming growth factor-alpha and the EGF receptor following nephrotoxic renal injury. Ren Fail. 2000;22(4):423-34.

We studied gene expression for transforming growth factor (TGF)-alpha, epidermal growth factor (EGF), heparin binding (HB) EGF, and the EGF receptor following acute renal failure induced by mercuric chloride administration to gain insight into potential mechanisms of renal repair.
31(0,1,1,1) Details
8052374 Taira T, Yoshimura A, Inui K, Oshiden K, Ideura T, Koshikawa S, Solez K: Immunochemical study of epidermal growth factor in rats with mercuric chloride-induced acute renal failure. Nephron. 1994;67(1):88-93.
7(0,0,1,2) Details
2396670 Coimbra TM, Cieslinski DA, Humes HD: Epidermal growth factor accelerates renal repair in mercuric chloride nephrotoxicity. Am J Physiol. 1990 Sep;259(3 Pt 2):F438-43.
7(0,0,1,2) Details
8230811 Iizuka K: [Immunohistochemical localization of epidermal growth factor in proximal tubules of rats with acute renal failure]. Nippon Jinzo Gakkai Shi. 1993 Sep;35(9):1015-21.

We investigated the expression of EGF in the renal tissues of mercuric-chloride (HgCl2, 2mg/kg)-induced ARF rats with (group-1) or without (group-2) platelet depletion for clarification of the role of EGF in the recovery of the renal tubules after ARF.
2(0,0,0,2) Details
7653601 Counts RS, Nowak G, Wyatt RD, Schnellmann RG: Nephrotoxicant inhibition of renal proximal tubule cell regeneration. Am J Physiol. 1995 Aug;269(2 Pt 2):F274-81.

To examine these issues, an in vitro model of mechanically induced injury to primary cultures of rabbit RPTC was developed, and the effects of epidermal growth factor (EGF), transforming growth factor-beta 1 (TGF-beta 1), and nephrotoxicants on the regenerative process were examined.
Mercuric chloride, fumonisin B1, and dichlorovinyl-L-cysteine, at concentrations < or = 50% of their lethal concentration, inhibited regeneration and resulted in swiped areas 3.7, 4.2, and 2.1 times larger, respectively, than controls on day 7.
1(0,0,0,1) Details
7635938 Homma T, Sakai M, Cheng HF, Yasuda T, Coffey RJ Jr, Harris RC: Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. J Clin Invest. 1995 Aug;96(2):1018-25.

The present studies examined whether expression of mRNA for the recently identified heparin-binding EGF-like growth factor (HB-EGF) is regulated in response to renal injury induced by either ischemia/reperfusion or mercuric chloride.
1(0,0,0,1) Details