| Name | interleukin 2 |
|---|---|
| Synonyms | Aldesleukin; IL 2; IL2; Interleukin 2; Interleukin 2 precursor; T cell growth factor; TCGF; lymphokine… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15032693 | Wu Z, MacPhee IA, Oliveira DB: Reactive species in the initiation of IL-4 driven autoimmunity as a potential therapeutic target. Curr Pharm Des. 2004;10(8):899-913. Cells primarily secreting interleukin-2 (IL-2) and interferon-gamma are known as Th1 cells and mediate classical cell-mediated immune responses such as delayed-type hypersensitivity. Study of an animal model of Th2-driven autoimmunity (mercuric chloride-induced autoimmunity in Brown Norway rats) has yielded insights into a possible role for oxidant stress in the generation of Th-2 driven autoimmune responses. |
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| 11844613 | Tuschl H, Landsteiner HT, Kovac R: Application of the popliteal lymph node assay in immunotoxicity testing: complementation of the direct popliteal lymph node assay with flow cytometric analyses. Toxicology. 2002 Mar 5;172(1):35-48. In the present investigation the direct PLNA was extended with the flow cytometric determinations of: (a) lymphoblasts; (b) the phenotyping of lymphoid subpopulations; (c) the determination of expression of proliferation/activation markers CD25, CD69 and CD62L/CD44 and (d) the analysis of intracellular cytokines interferon gamma, interleukin 2 and interleukin 4. |
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| 7867075 | Prigent P, Poncet P, Aten J, Blanpied C, Chand A, Fevrier M, Druet P, Hirsch F: Mercuric chloride-induced programmed cell death of a murine T cell hybridoma. Cell Immunol. 1995 Mar;161(1):107-11. Opposite effect of interleukin-2 and interleukin-4.. |
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| 8469923 | Dubey D, Kuhn J, Vial MC, Druet P, Bellon B: Anti-interleukin-2 receptor monoclonal antibody therapy supports a role for Th1-like cells in HgCl2-induced autoimmunity in rats. Scand J Immunol. 1993 Apr;37(4):406-12. |
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| 10529590 | Loftenius A, Ekstrand J, Moller E: HgCl (2)-induced human lymphocyte activation in vitro: a superantigenic mechanism?. Int Arch Allergy Immunol. 1999 Sep;120(1):63-70. Mercuric chloride (HgCl (2)) has been proposed to be a mitogen for human blood lymphocytes in vitro. Furthermore, if cells were pretreated for 5 days with HgCl (2), whereafter recombinant interleukin-2 in fresh medium was added, the TCR Vbeta7+ T cell subset was also stimulated to blast transformation. |
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| 8449215 | van der Meide PH, de Labie MC, Botman CA, van Bennekom WP, Olsson T, Aten J, Weening JJ: Mercuric chloride down-regulates T cell interferon-gamma production in brown Norway but not in Lewis rats; role of Eur J Immunol. 1993 Mar;23(3):675-81. |
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| 9135547 | Hu H, Abedi-Valugerdi M, Moller G: Pretreatment of lymphocytes with mercury in vitro induces a response in T cells from genetically determined low-responders and a shift of the interleukin profile. Immunology. 1997 Feb;90(2):198-204. We found that in vitro mercuric chloride induced a high proliferative response in spleen lymphocytes from mercury-susceptible SJL mice, but a low response in resistant mice, such as C57BL/6 (H-2b), A/J (H-2a) and CBA (H-2k) mice. |
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| 10861847 | Du J, Suzuki H, Nagase F, Akhand AA, Yokoyama T, Nakashima I: Mercuric chloride stimulates distinct signal transduction pathway for DNA synthesis in a T-cell line, CTLL-2. J Cell Biochem. 2000 Jun 6;78(3):500-8. Exposure of an interleukin-2 (IL-2)-dependent murine T-cell line (CTLL-2) to mercuric chloride in in vitro culture induced a low but definite level of DNA synthesis in the absence of exogenous IL-2, and further enhanced the IL-2-induced DNA synthesis. |
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| 8478610 | Mathieson PW, Thiru S, Oliveira DB: Regulatory role of OX22high T cells in mercury-induced autoimmunity in the brown Norway rat. J Exp Med. 1993 May 1;177(5):1309-16. The monoclonal antibody OX22 defines a functional split within CD4+ T cells in the rat, with OX22high cells mainly producing interleukin 2 (IL-2) and interferon gamma and responsible for delayed-type hypersensitivity responses, and OX22low cells mainly producing IL-4 and -5 and responsible for providing B cell help. We have used OX22 in vivo to define the role of these subsets in mercuric chloride-induced autoimmunity in the Brown Norway rat. |
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| 3264770 | Baran D, Lantz O, Dosquet P, Sfaksi A, Druet P: Interleukin-2 production in Brown-Norway rats with HgCl2-induced autoimmune disease: paradoxical in vivo versus in vitro findings. Clin Exp Immunol. 1988 Sep;73(3):401-5. |
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