| Name | alkaline phosphatase |
|---|---|
| Synonyms | ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19382722 | Zhao JQ, Wen YF, Bhadauria M, Nirala SK, Sharma A, Shrivastava S, Shukla S, Agrawal OP, Mathur R: Protective effects of propolis on inorganic mercury induced oxidative stress in mice. Indian J Exp Biol. 2009 Apr;47(4):264-9. Exposure to mercuric chloride (HgCl2; 5 mg/kg; ip) induced oxidative stress by increasing lipid peroxidation and level along with concomitant decrease in and various antioxidant enzymes. Release of serum transaminases, alkaline phosphatase, lactate dehydrogenase and y-glutamyl transpeptidase were significantly restored towards control after propolis treatment. |
1(0,0,0,1) | Details |
| 12490134 | Jin GB, Inoue S, Urano T, Cho S, Ouchi Y, Cyong JC: Induction of anti-metallothionein antibody and mercury treatment decreases bone mineral density in mice. Toxicol Appl Pharmacol. 2002 Dec 1;185(2):98-110. Mercuric chloride (HgCl2) is an industrial agent with toxic effects on the immune system, kidney, lung, and nervous tissue, but little is known about its effect on bone. MT immunization plus HgCl2 treatment dramatically decreased bone mineral density (BMD), and the humoral bone formation indices, alkaline phosphatase (ALP) activity and osteocalcin. |
1(0,0,0,1) | Details |
| 18758054 | Ghosh A, Sil PC: A protein from Cajanus indicus Spreng protects liver and kidney against mercuric chloride-induced oxidative stress. Biol Pharm Bull. 2008 Sep;31(9):1651-8. In addition, HgCl (2) increased the activities of serum marker enzymes (namely, glutamate pyruvate transaminase, GPT and alkaline phosphatase, ALP), blood urea and serum tumor necrosis factor alpha (TNF-alpha) level along with hepatic and renal lipid peroxidation. |
1(0,0,0,1) | Details |
| 1477095 | Cote YP, Ouellet S, Beaudoin AR: Kinetic properties of type-II ATP diphosphohydrolase from the tunica media of the bovine aorta. Biochim Biophys Acta. 1992 Dec 28;1160(3):246-50. It is insensitive to ouabain (3 mM), an inhibitor of Na+/K (+)-ATPase, to tetramisole (5 mM), an inhibitor of alkaline phosphatase, and to Ap5A (100 microM), an inhibitor of kinase. Mercuric chloride (10 microM) and 5'-p-fluorosulfonylbenzoyl are also powerful inhibitors, both with ATP and ADP as substrates. |
1(0,0,0,1) | Details |
| 7912137 | Bret L, Hasim M, Lefebvre H, Fournie GJ, Braun JP: Kidney tubule enzymes and extracellular DNA in urine as markers for nephrotoxicity in the guinea pig. Enzyme Protein. 1993;47(1):27-36. Guinea pigs were given a single intraperitoneal injection of 1.35 mg/kg body weight of mercuric chloride; then various kidney enzymes and extracellular DNA were assayed in urine. Sequential collection of urines allowed for kinetic studies: membrane markers alkaline phosphatase and gamma-glutamyltransferase were first released, then cytosolic lactate dehydrogenase and mitochondrial dehydrogenase, finally extracellular DNA; DNA release is equated with cell death. |
1(0,0,0,1) | Details |
| 12928767 | Mahieu ST, Gionotti M, Millen N, Elias MM: Effect of chronic accumulation of aluminum on renal function, cortical renal oxidative stress and cortical renal organic anion transport in rats. Arch Toxicol. 2003 Nov;77(11):605-12. Epub 2003 Aug 20. The activity of alkaline phosphatase (AP) relative to inulin excreted in urine was significantly impaired: controls 2.2+/-0.6 IUI/mg, Al-treated 5.1+/-0.5 IU/mg, P <0.05. |
1(0,0,0,1) | Details |
| 8580532 | Shakoori AR, Kokab R, Mahjabeen G, Anjum F, Ali SS: Effect of mercuric chloride on the activities of some hepatic enzymes of regenerating rabbit liver following partial hepatectomy. Acta Physiol Pharmacol Ther Latinoam. 1995;45(3):177-84. After withdrawal of HgCl2 treatment for 10 days, the LDH and glutamate pyruvate transaminase (GPT) activities showed 56% and 40% decrease, respectively, while alkaline phosphatase (AkP) activity increased 4.12 fold. |
1(0,0,0,1) | Details |
| 7884643 | Anjum F, Shakoori AR: Sublethal effects of inorganic mercury on the body growth rate and liver function enzymes of phenobarbitone-pretreated and promethazine-pretreated rabbits. J Environ Pathol Toxicol Oncol. 1994;13(2):125-32. After phenobarbitone (PB) treatment, the serum transaminase (GOT), glutamate pyruvate transaminase (GPT), isocitrate dehydrogenase (ICDH), and lactate dehydrogenase (LDH) activities decreased to 31%, 77%, 20%, and 27%, respectively, whereas the serum alkaline phosphatase (AP) activity increased 54%. After mercuric chloride (HgCl2) treatment, the serum GOT, GPT, LDH, and ICDH activities decreased 69%, 83%, 11%, and 48%, respectively. |
1(0,0,0,1) | Details |
| 20307147 | Rao MV, Purohit A, Patel T: protection on mercury-exerted brain toxicity in the rat. Drug Chem Toxicol. 2010 Apr;33(2):209-16. The effect of on the neurotoxicity induced by mercuric chloride was studied. The results suggest that the graded doses of mercury elicit the depletion of enzymatic activities, such as triphosphatase, succinate dehydrogenase, phosphorylase, alkaline phosphatase, acid phosphatase, altered total protein, and lipid peroxidation levels in the cerebral hemisphere, cerebellum, and medulla oblongata of the brain, thereby affecting their respective functions. |
1(0,0,0,1) | Details |
| 12815612 | Reus IS, Bando I, Andres D, Cascales M: Relationship between expression of HSP70 and metallothionein and oxidative stress during mercury induced acute liver injury in rats. J Biochem Mol Toxicol. 2003;17(3):161-8. HgCl (2) at the doses of 0.1 mg/kg induced liver injury detected by a slight increase in serum aspartate aminotransferase and alkaline phosphatase activities and by the enhanced levels of |
1(0,0,0,1) | Details |
| 17215067 | Sharma MK, Sharma A, Kumar A, Kumar M: Evaluation of protective efficacy of Spirulina fusiformis against mercury induced nephrotoxicity in Swiss albino mice. Food Chem Toxicol. 2007 Jun;45(6):879-87. Epub 2006 Nov 23. Spirulina extract was administered orally. (iv) Combination group--S. fusiformis was administered 10 days before mercuric chloride administration and continued upto 30 days after mercuric chloride administration (5.0 mg/kg b.wt.). The animals were autopsied on 1, 3, 7, 15 and 30 days after treatment and the activity of alkaline phosphatase (ALP), acid phosphatase (ACP), lactate dehydrogenase (LDH) and MDA (malondialdehyde) level were measured in kidney homogenates. |
1(0,0,0,1) | Details |
| 2396895 | Olczyk K, Kucharz EJ, Wieczorek M, Szczebara M, Sonecki P: Collagen and elastin in the liver of rats intoxicated with mercuric chloride. Arh Hig Rada Toksikol. 1990 Mar;41(1):1-6. The increase was associated with elevated serum aminotransferase and alkaline phosphatase activities, and decreased total protein level in serum. |
1(0,0,0,1) | Details |
| 12508136 | Ramalingam V, Vimaladevi V: Effect of mercuric chloride on membrane-bound enzymes in rat testis. . Asian J Androl. 2002 Dec;4(4):309-11. Alkaline phosphatase and ggr-glutamyl transferase activities were significantly increased (P < 0.01) in both groups. |
1(0,0,0,1) | Details |
| 18405108 | Jagadeesan G, Sankarsami Pillai S: Hepatoprotective effects of against mercury induced toxicity in rats. J Environ Biol. 2007 Oct;28(4):753-6. The animals were treated with sublethal dose of mercuric chloride (2 mg/kg body wt.) for 30 days. During the mercury treatment, the level ofAspartate transaminase (AST), transaminase (ALT) and Alkaline phosphatase (ALP) in serum and lipid peroxidation (LPO) in liver tissue significantly increased whereas (GSH), peroxidase (GPx), Catalase (CAT) and Superoxide dismutase (SOD) were simultaneously decreased in the liver tissue. |
1(0,0,0,1) | Details |
| 1539167 | Aleo MD, Taub ML, Kostyniak PJ: Primary cultures of rabbit renal proximal tubule cells. Toxicol Appl Pharmacol. 1992 Feb;112(2):310-7. The present study further developed primary cultures of rabbit renal proximal tubule cells (RPTC) as an in vitro model to study chemical-induced toxicity by investigating the comparative cytotoxicity of mercuric chloride (HgCl2) and methyl mercury (CH3HgCl) to RPTC. |
0(0,0,0,0) | Details |
| 7715860 | Albrecht J, Szumanska G, Gadamski R, Gajkowska B: Changes of activity and ultrastructural localization of alkaline phosphatase in cerebral cortical microvessels of rat after single intraperitoneal administration of mercuric chloride. Neurotoxicology. 1994 Winter;15(4):897-902. |
12(0,0,2,2) | Details |
| 1354752 | Dieter MP, Boorman GA, Jameson CW, Eustis SL, Uraih LC: Development of renal toxicity in F344 rats gavaged with mercuric chloride for 2 weeks, or 2, 4, 6, 15, and 24 months. J Toxicol Environ Health. 1992 Aug;36(4):319-40. In response to mercuric chloride exposure of 5.0 mg/kg for 2-6 mo, the greatest and most persistent increases in elevation of urinary enzyme activities were exhibited by alkaline phosphatase and gamma-glutamyl transferase, which increased two-to threefold above controls. |
7(0,0,1,2) | Details |
| 15511004 | Saxena PS, Kumar M: Modulatory potential of Spirulina fusiformis on testicular phosphatases in Swiss albino mice against mercury intoxication. Indian J Exp Biol. 2004 Oct;42(10):998-1002. Administration of mercuric chloride (HgCl2; 5.0 mg/kg body weight) to male Swiss albino-mice resulted in significantly higher levels of testicular acid phosphatase and alkaline phosphatase (ALP) activities as compared to control. |
6(0,0,1,1) | Details |
| 19576259 | Rao MV, Chhunchha B: Protective role of against the mercury induced oxidative stress in the rat thyroid. Food Chem Toxicol. 2010 Jan;48(1):7-10. Epub 2009 Jul 1. Present study investigated the protective role of (MLT, 5mg/kg body wt., ip) against the long term effects of mercuric chloride (MC; 2 and 4 mg/kg body wt., po) in the thyroid gland of the rats through certain antioxidative indices like superoxide dismutase (SOD), peroxidase (GPx), glutathione reductase (GR), (GSH), catalase (CAT) and lipid peroxidation (LPO), other biochemical parameters such as succinate dehydrogenase (SDH), triphosphatase (ATPase), acid phosphatase (ACPase) and alkaline phosphatase (ALPase) were also measured. |
6(0,0,1,1) | Details |
| 17041551 | Jagadeesan G, Kavitha AV: Recovery of phosphatase and transaminase activity of mercury intoxicated Mus musculus (Linn.) liver tissue by Tribulus terrestris (Linn.) (Zygophyllaceae) extract. Trop Biomed. 2006 Jun;23(1):45-51. At a median-lethal dose of mercuric chloride (12.9 mg/kg body wt.) administration an enhanced level of oxaloacete transaminase (GOT), transminase (GPT) and simultaneously decreased level of acid phosphatase (ACP) and alkaline phosphatase (ALT) activities were noticed in the liver. |
6(0,0,1,1) | Details |
| 3449639 | Ohata H, Momose K, Takahashi A, Omori Y: Urinalysis for detection of chemically induced renal damage (1)--Changes in urinary excretions of enzymes and various components caused by mercuric chloride and gentamicin. J Toxicol Sci. 1987 Nov;12(4):341-55. Daily administration of mercuric chloride (HgCl2) dose-dependently increased urinary excretions of lactate dehydrogenase (LDH), aspartate aminotransferase (GOT), alkaline phosphatase (ALP), leucine aminopeptidase (LAP), lysozyme (LZM), N-acetyl-beta-D-glucosaminidase (NAG), and acid protease together with increased counts of tubular cells in the urine. |
6(0,0,1,1) | Details |
| 8756758 | Hoyer PE, Kirkeby S: The impact of fixatives on the binding of lectins to N-acetyl- residues of human syncytiotrophoblast: a quantitative histochemical study. J Histochem Cytochem. 1996 Aug;44(8):855-63. The method employs biotinylated lectins and alkaline phosphatase-conjugated avidin. Acid fixatives or fixatives containing mercuric chloride, e.g., Carnoy's and Zenker's fixatives, gave intense specific lectin binding and low background staining. |
4(0,0,0,4) | Details |
| 12587743 | Sharma MK, Kumar M, Kumar A: Ocimum sanctum aqueous leaf extract provides protection against mercury induced toxicity in Swiss albino mice. Indian J Exp Biol. 2002 Sep;40(9):1079-82. In serum of HgCl2 treated mice there was significant elevation in serum transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) activities but significant decline in the alkaline phosphatase activity. |
2(0,0,0,2) | Details |
| 17061558 | Yu ZJ, Yang Q, Yang XD, Wang K: [Monitoring early toxicity of heavy metals including Hg using a HSE-SEAP reporter gene]. Zhongguo Zhong Yao Za Zhi. 2006 Aug;31(16):1346-9. OBJECTIVE: To develop a cellular assay based on heat shock signal pathway and secreted alkaline phosphatase (SEAP) reporter gene for investigating/predicting the early toxicity of heavy metals on HeLa cells in Chinese traditional medicine (TCM). |
2(0,0,0,2) | Details |
| 19340551 | Watanabe T, Fujii T, Oya T, Horikawa N, Tabuchi Y, Takahashi Y, Morii M, Takeguchi N, Tsukada K, Sakai H: Involvement of aquaporin-5 in differentiation of human gastric cancer cells. J Physiol Sci. 2009 Mar;59(2):113-22. Epub 2009 Jan 14. The AQP5 expression significantly increased the proportion of differentiated cells with a spindle shape, the activity of alkaline phosphatase, a marker for the intestinal epithelial cell type of cancer cells, and the expression level of laminin, an epithelial cell marker. |
2(0,0,0,2) | Details |
| 8095245 | Jonker D, Jones MA, van Bladeren PJ, Woutersen RA, Til HP, Feron VJ: Acute (24 hr) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds. Food Chem Toxicol. 1993 Jan;31(1):45-52. To identify possible hazards of combined exposure to chemicals with the same target organ, a 24-hr single dose experiment was carried out in which the renal toxicity of mercuric chloride, dichromate, and hexachloro-1:3-butadiene administered simultaneously was compared with the nephrotoxicity of the individual compounds, using a total of 11 groups each consisting of five 12-wk-old male Wistar rats. Synergism of effects was also observed, for example increased severity of renal tubular necrosis, and more markedly increased activity of urinary lysozyme, lactate dehydrogenase, alkaline phosphatase and N-acetyl-beta-glucosaminidase. |
1(0,0,0,1) | Details |
| 8444844 | Picher M, Cote YP, Beliveau R, Potier M, Beaudoin AR: Demonstration of a novel type of ATP-diphosphohydrolase (EC 3.6.1.5) in the bovine lung. J Biol Chem. 1993 Mar 5;268(7):4699-703. It requires Ca2+ or Mg2+ and is insensitive to ouabain, an inhibitor of Na+/K (+)-ATPase, P1,P5-di 5')-pentaphosphate, an inhibitor of kinase, and tetramisole, an inhibitor of alkaline phosphatase. In contrast, azide (10 mM), a known inhibitor of ATPDases and mitochondrial ATPases, as well as mercuric chloride (10 microM) and gossypol (2,2'-bis [8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]) (35 microM) are powerful inhibitors of this enzyme. |
1(0,0,0,1) | Details |
| 1983769 | Starnawska M, Hac E: The activity of several enzymes in the urine and blood of animals in experimental poisoning with sublimate. Bull Inst Marit Trop Med Gdynia. 1990;41(1-4):89-96. In the urine an increase of activity of alkaline phosphatase and lactate dehydrogenase was noted. |
2(0,0,0,2) | Details |
| 18443381 | El-Shenawy SM, Hassan NS: Comparative evaluation of the protective effect of and garlic against liver and kidney damage induced by mercury in the rats. Pharmacol Rep. 2008 Mar-Apr;60(2):199-208. The results revealed that the rats injected with HgCl (2) showed a significant increase in levels of blood urea (BUN), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) by 29.3%, 62.5%, 29.46% and 30.61%, respectively, while alkaline phosphatase (ALP) showed a significant decrease by 22.6% as compared with saline control group. |
1(0,0,0,1) | Details |
| 2841777 | Klonne DR, Johnson DR: Enzyme activity and sulfhydryl status in rat renal cortex following mercuric chloride and administration. Toxicol Lett. 1988 Aug;42(2):199-205. The present studies investigated whether DTT, a sulfhydryl reducing agent, protected renal cortical sulfhydryl status in general, or the activity of various renal enzymes (Mg- and Na,K-ATPases, alkaline phosphatase, and peroxidase) in particular. |
1(0,0,0,1) | Details |