Protein Information

Name aspartate aminotransferase
Synonyms Aspartate Aminotransferase 1; GIG18; GOT 1; GOT1; Aspartate aminotransferase; Glutamate oxaloacetate transaminase 1; Transaminase A; Aspartate aminotransferases…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
1982872 Gill TS, Tewari H, Pande J: Use of the fish enzyme system in monitoring water quality: effects of mercury on tissue enzymes. Comp Biochem Physiol C. 1990;97(2):287-92.

Rosy barb (Puntius conchonius) were exposed to 181 micrograms/l mercuric chloride for 48 h and the activity of acid and alkaline phosphatases (AcP and AIP), aspartate aminotransferase (AAT), alanine aminotransferase (AIAT), lactic dehydrogenase (LDH), and acetylcholinesterase (AchE) were measured in vivo in several organs. 2.
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3449639 Ohata H, Momose K, Takahashi A, Omori Y: Urinalysis for detection of chemically induced renal damage (1)--Changes in urinary excretions of enzymes and various components caused by mercuric chloride and gentamicin. J Toxicol Sci. 1987 Nov;12(4):341-55.

Daily administration of mercuric chloride (HgCl2) dose-dependently increased urinary excretions of lactate dehydrogenase (LDH), aspartate aminotransferase (GOT), alkaline phosphatase (ALP), leucine aminopeptidase (LAP), lysozyme (LZM), N-acetyl-beta-D-glucosaminidase (NAG), and acid protease together with increased counts of tubular cells in the urine.
6(0,0,1,1) Details
18443381 El-Shenawy SM, Hassan NS: Comparative evaluation of the protective effect of selenium and garlic against liver and kidney damage induced by mercury chloride in the rats. Pharmacol Rep. 2008 Mar-Apr;60(2):199-208.


The results revealed that the rats injected with HgCl (2) showed a significant increase in levels of blood urea nitrogen (BUN), serum creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST) by 29.3%, 62.5%, 29.46% and 30.61%, respectively, while alkaline phosphatase (ALP) showed a significant decrease by 22.6% as compared with saline control group.
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12815612 Reus IS, Bando I, Andres D, Cascales M: Relationship between expression of HSP70 and metallothionein and oxidative stress during mercury chloride induced acute liver injury in rats. J Biochem Mol Toxicol. 2003;17(3):161-8.


HgCl (2) at the doses of 0.1 mg/kg induced liver injury detected by a slight increase in serum aspartate aminotransferase and alkaline phosphatase activities and by the enhanced levels of bilirubin.
1(0,0,0,1) Details
7482568 Bucio L, Souza V, Albores A, Sierra A, Chavez E, Carabez A, Gutierrez-Ruiz MC: Cadmium and mercury toxicity in a human fetal hepatic cell line (WRL-68 cells). Toxicology. 1995 Sep 18;102(3):285-99.


Cell damage was also measured by alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT) activities.
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16964587 Brandao R, Santos FW, Farina M, Zeni G, Bohrer D, Rocha JB, Nogueira CW: Antioxidants and metallothionein levels in mercury-treated mice. Cell Biol Toxicol. 2006 Nov;22(6):429-38. Epub 2006 Sep 11.


Mice received a single dose of mercuric chloride (HgCl2, 4.6 mg/kg, subcutaneously) for three consecutive days.
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