| Name | PK1 |
|---|---|
| Synonyms | Black mamba toxin related protein; PRK 1; PRK1; EG VEGF; EGVEGF; Endocrine gland derived vascular endothelial growth factor; Mambakine; PK1… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9344897 | Endo T, Kimura O, Sakata M, Shaikh ZA: Mercury uptake by LLC-PK1 cells: dependence on temperature and membrane potential. Toxicol Appl Pharmacol. 1997 Oct;146(2):294-8. |
4(0,0,0,4) | Details |
| 10494917 | Divine KK, Ayala-Fierro F, Barber DS, Carter DE: albumin, and cys-gly effects on toxicity and accumulation of mercuric chloride in LLC-PK1 cells. J Toxicol Environ Health A. 1999 Aug 13;57(7):489-505. |
8(0,0,1,3) | Details |
| 9644625 | Andersen KJ, Maunsbach AB, Christensen EI: Biochemical and ultrastructural characterization of fluid transporting LLC-PK1 microspheres. J Am Soc Nephrol. 1998 Jul;9(7):1153-68. |
3(0,0,0,3) | Details |
| 16759985 | Liu F, Inageda K, Nishitai G, Matsuoka M: Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cells. Environ Health Perspect. 2006 Jun;114(6):859-64. Compared with other heavy-metal compounds such as zinc mercuric chloride, and lead CdCl2 could increase the levels of Grp78, ATF4, and the phosphorylated form of eIF2 (alpha) more markedly without definite cellular damage. |
2(0,0,0,2) | Details |
| 10696784 | Matsuoka M, Wispriyono B, Iryo Y, Igisu H: Mercury activates c-Jun N-terminal kinase and induces c-jun expression in LLC-PK1 cells. Toxicol Sci. 2000 Feb;53(2):361-8. |
2(0,0,0,2) | Details |
| 9463523 | Matsuoka M, Wispriyono B, Igisu H: Induction of c-fos gene by mercury in LLC-PK1 cells. Chem Biol Interact. 1997 Dec 12;108(1-2):95-106. |
2(0,0,0,2) | Details |
| 12197277 | Aleo MF, Morandini F, Bettoni F, Tanganelli S, Vezzola A, Giuliani R, Steimberg N, Boniotti J, Bertasi B, Losio N, Apostoli P, Mazzoleni G: [In vitro study of the nephrotoxic mechanism of mercuric chloride] . Med Lav. 2002 May-Jun;93(3):267-78. For this purpose, two kidney-derived in vitro systems (the MDCK and the LLC-PK1 cell lines) were tested for their sensitivity to the salt, and MDCK was chosen as the most suitable in vitro model for our study. |
1(0,0,0,1) | Details |
| 10426573 | Ogasawara M, Nomura K, Shibata N, Ujihara M, Kobayashi M, Demura H: Surgical stress increases renal content via increased glucocorticoid, and resistance to subsequent oxidative injury in the rat: significant link between endocrine response and cell defense system under the stress. Endocr J. 1999 Feb;46(1):99-106. Cellular GSH content of LLC-PK1 cells, porcine renal-tubule-derived culture cells, increased significantly in incubation with dexamethasone or suggesting that steroids directly stimulate renal cell GSH. Rats were then injected s.c. with mercuric chloride (HgCl2) to oxidatively injure renal tubuli. |
1(0,0,0,1) | Details |
| 8702935 | Sapirstein A, Spech RA, Witzgall R, Bonventre JV: Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates peroxide cytotoxicity in kidney epithelial cells. J Biol Chem. 1996 Aug 30;271(35):21505-13. LLC-PK1 cell lines were created that express either the cytosolic PLA2 or a group II PLA2. Exposure to peroxide or but not mercuric chloride, resulted in significantly greater lactate dehydrogenase release in LLC-cPLA2 cells when compared with control cells. |
1(0,0,0,1) | Details |
| 8872981 | Nath KA, Croatt AJ, Likely S, Behrens TW, Warden D: Renal oxidant injury and oxidant response induced by mercury. Kidney Int. 1996 Sep;50(3):1032-43. The role of oxidative stress in mercuric chloride (HgCl2)-induced nephrotoxicity is uncertain and controversial. We demonstrate that I.L.C-PK1 cells, exposed to HgCl2, generate massive amounts of peroxide, the latter completely quenched by the peroxide scavenger, |
1(0,0,0,1) | Details |