Protein Information

Name ROC1
Synonyms GTP binding protein Rit1; RIT 1; RIT1; ROC 1; ROC1; GTP binding protein Roc1; RIBB; RIT…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
10748083 Chen A, Wu K, Fuchs SY, Tan P, Gomez C, Pan ZQ: The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation. J Biol Chem. 2000 May 19;275(20):15432-9.

Mercury-containing sulfhydryl modification agents (rho-hydroxymercuribenzoate and mercuric chloride) irreversibly inhibit the ROC1-CUL1 ubiquitin ligase activity without disrupting the complex.
88(1,1,1,8) Details