| Name | glutamyl transpeptidase |
|---|---|
| Synonyms | CD224; CD224 antigen; D22S672; D22S732; GGT; GGT 1; GGT1; GGT1 protein… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 2900543 | Barakat SE, Ford EJ: Further studies on the diagnostic value of gamma-glutamyl transpeptidase and 5'-nucleotidase in cattle, sheep and horses. Res Vet Sci. 1988 May;44(3):354-60. The kidney lesion in sheep produced by the intravenous administration of mercuric chloride is accompanied by a reduction in the rate of excretion of an injected dose of inulin and by an increase in the concentration of urea in plasma and in the activity of gamma-GT in plasma and urine. |
83(1,1,1,3) | Details |
| 1354752 | Dieter MP, Boorman GA, Jameson CW, Eustis SL, Uraih LC: Development of renal toxicity in F344 rats gavaged with mercuric chloride for 2 weeks, or 2, 4, 6, 15, and 24 months. J Toxicol Environ Health. 1992 Aug;36(4):319-40. In response to mercuric chloride exposure of 5.0 mg/kg for 2-6 mo, the greatest and most persistent increases in elevation of urinary enzyme activities were exhibited by alkaline phosphatase and gamma-glutamyl transferase, which increased two-to threefold above controls. |
6(0,0,1,1) | Details |
| 7916024 | de Ceaurriz J, Payan JP, Morel G, Brondeau MT: Role of extracellular and gamma-glutamyltranspeptidase in the disposition and kidney toxicity of inorganic mercury in rats. J Appl Toxicol. 1994 May-Jun;14(3):201-6. The role of extracellular (GSH) and membrane-bound gamma-glutamyltranspeptidase (gamma-GT) as contributory factors in the disposition and toxicity of inorganic mercury (HgCl2, 1 mg kg-1, i.p.) was investigated in rats pretreated with acivicin (AT-125, 10 mg kg-1), a gamma-GT inhibitor. |
6(0,0,0,6) | Details |
| 7785056 | Zalups RK: Organic anion transport and action of gamma-glutamyl transpeptidase in kidney linked mechanistically to renal tubular uptake of inorganic mercury. Toxicol Appl Pharmacol. 1995 Jun;132(2):289-98. Dispositional data were obtained at both 1 and 24 hr after a nontoxic, 0.5 mumol/kg iv dose of mercuric chloride had been administered. |
4(0,0,0,4) | Details |
| 8689530 | Holmes E, Bonner FW, Nicholson JK: Comparative biochemical effects of low doses of mercury II in the F344 rat and the multimammate mouse (Mastomys natalensis). Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1996 May;114(1):7-15. Urinary gamma GT activity was found to be much higher in F344 rats than Mastomys. |
2(0,0,0,2) | Details |
| 15920625 | Park HJ, Moon JS, Kim HG, Kim IH, Kim K, Park EH, Lim CJ: Characterization of a second gene encoding gamma-glutamyl transpeptidase from Schizosaccharomyces pombe. Can J Microbiol. 2005 Mar;51(3):269-75. The S. pombe cells harboring plasmid pPHJ02 showed increased survival on solid media containing peroxide, diethylmaleate, aluminum cadmium or mercuric chloride. |
2(0,0,0,2) | Details |
| 9528259 | Yanagisawa H: [HgCl2-induced acute renal failure and its pathophysiology] . Nippon Eiseigaku Zasshi. 1998 Jan;52(4):618-23. The Hg (2+)-GSH complex is filtered in the glomeruli of the kidney and degraded into Hg (2+)- in the proximal tubules by the combined action of gamma-glutamyl transpeptidase and dipeptidase present in the epithelial cells. |
1(0,0,0,1) | Details |
| 15977196 | Bando I, Reus MI, Andres D, Cascales M: Endogenous antioxidant defence system in rat liver following mercury oral intoxication. J Biochem Mol Toxicol. 2005;19(3):154-61. HgCl2 at the doses of 0.1 mg/kg produced liver damage which that was detected by a slight increase in serum alanine aminotransferase and gamma glutamyl transferase. |
1(0,0,0,1) | Details |
| 19382722 | Zhao JQ, Wen YF, Bhadauria M, Nirala SK, Sharma A, Shrivastava S, Shukla S, Agrawal OP, Mathur R: Protective effects of propolis on inorganic mercury induced oxidative stress in mice. Indian J Exp Biol. 2009 Apr;47(4):264-9. Exposure to mercuric chloride (HgCl2; 5 mg/kg; ip) induced oxidative stress by increasing lipid peroxidation and level along with concomitant decrease in and various antioxidant enzymes. Release of serum transaminases, alkaline phosphatase, lactate dehydrogenase and y-glutamyl transpeptidase were significantly restored towards control after propolis treatment. |
1(0,0,0,1) | Details |
| 1983769 | Starnawska M, Hac E: The activity of several enzymes in the urine and blood of animals in experimental poisoning with sublimate. Bull Inst Marit Trop Med Gdynia. 1990;41(1-4):89-96. In the blood plasma an increase of lactate dehydrogenase activity was observed and in the blood serum decrease of gamma-glutamyl-transpeptidase activity. |
1(0,0,0,1) | Details |
| 7912137 | Bret L, Hasim M, Lefebvre H, Fournie GJ, Braun JP: Kidney tubule enzymes and extracellular DNA in urine as markers for nephrotoxicity in the guinea pig. Enzyme Protein. 1993;47(1):27-36. Guinea pigs were given a single intraperitoneal injection of 1.35 mg/kg body weight of mercuric chloride; then various kidney enzymes and extracellular DNA were assayed in urine. Sequential collection of urines allowed for kinetic studies: membrane markers alkaline phosphatase and gamma-glutamyltransferase were first released, then cytosolic lactate dehydrogenase and mitochondrial dehydrogenase, finally extracellular DNA; DNA release is equated with cell death. |
1(0,0,0,1) | Details |
| 8095245 | Jonker D, Jones MA, van Bladeren PJ, Woutersen RA, Til HP, Feron VJ: Acute (24 hr) toxicity of a combination of four nephrotoxicants in rats compared with the toxicity of the individual compounds. Food Chem Toxicol. 1993 Jan;31(1):45-52. To identify possible hazards of combined exposure to chemicals with the same target organ, a 24-hr single dose experiment was carried out in which the renal toxicity of mercuric chloride, dichromate, and hexachloro-1:3-butadiene administered simultaneously was compared with the nephrotoxicity of the individual compounds, using a total of 11 groups each consisting of five 12-wk-old male Wistar rats. At the MNEL of the combination, antagonism of effects was encountered, seen for example as less severely increased activity of gamma-glutamyl transferase in the urine. |
1(0,0,0,1) | Details |
| 3449639 | Ohata H, Momose K, Takahashi A, Omori Y: Urinalysis for detection of chemically induced renal damage (1)--Changes in urinary excretions of enzymes and various components caused by mercuric chloride and gentamicin. J Toxicol Sci. 1987 Nov;12(4):341-55. |
0(0,0,0,0) | Details |