| Name | nucleolar protein (protein family or complex) |
|---|---|
| Synonyms | NOL1/NOP2/Sun domain family; nucleolar protein; nucleolar proteins |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9237798 | Johansson U, Sander B, Hultman P: Effects of the murine genotype on T cell activation and cytokine production in murine mercury-induced autoimmunity. J Autoimmun. 1997 Aug;10(4):347-55. Mercury induces a systemic autoimmune condition characterized by auto-antibodies to the nucleolar protein fibrillarin (AFA) and systemic immune-complex (IC) deposits in genetically susceptible mouse strains. |
1(0,0,0,1) | Details |
| 2612058 | Hultman P, Enestrom S, Pollard KM, Tan EM: Anti-fibrillarin autoantibodies in mercury-treated mice. Clin Exp Immunol. 1989 Dec;78(3):470-7. B10.S mice treated with mercuric chloride consistently developed ANuA, which also targeted a 34-kD nucleolar protein. |
83(1,1,1,3) | Details |
| 17084957 | Havarinasab S, Bjorn E, Ekstrand J, Hultman P: Dose and Hg species determine the T-helper cell activation in murine autoimmunity. Toxicology. 2007 Jan 5;229(1-2):23-32. Epub 2006 Sep 24. Inorganic mercury (mercuric chloride--HgCl (2)) induces in mice an autoimmune syndrome (HgIA) with T cell-dependent polyclonal B cell activation and hypergammaglobulinemia, dose- and H-2-dependent production of autoantibodies targeting the 34 kDa nucleolar protein fibrillarin (AFA), and systemic immune-complex deposits. |
81(1,1,1,1) | Details |
| 12388758 | Chen M, Rockel T, Steinweger G, Hemmerich P, Risch J, von Mikecz A: Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: implications for processing of a nucleolar autoantigen. Mol Biol Cell. 2002 Oct;13(10):3576-87. Because proteasomes are absent from the nucleolus, a recruitment system was used to analyze the molecular fate of nucleolar protein fibrillarin: Subtoxic concentrations of mercuric chloride (HgCl (2)) induce subcellular redistribution of fibrillarin and substantial colocalization (33%) with nucleoplasmic proteasomes in different cell lines and in primary cells isolated from mercury-treated mice. |
31(0,1,1,1) | Details |
| 9600807 | Hultman P, Nielsen JB: The effect of toxicokinetics on murine mercury-induced autoimmunity. Environ Res. 1998 May;77(2):141-8. Mercury induces autoantibodies to the nucleolar protein fibrillarin (ANoA) in genetically susceptible (H-2AS) mouse strains. |
1(0,0,0,1) | Details |
| 8738957 | Hultman P, Turley SJ, Enestrom S, Lindh U, Pollard KM: Murine genotype influences the specificity, magnitude and persistence of murine mercury-induced autoimmunity. J Autoimmun. 1996 Apr;9(2):139-49. We studied the influence of genotype on systemic autoimmunity by treating female mice of the H-2s strains SJL/N, SJL/J, A.SW, and B10.S with mercuric chloride (HgCl2) for 10 weeks and then following autoantibody and tissue immune deposits during the subsequent 12 months. All strains developed antinucleolar antibodies (ANoA) of the IgG class which reacted in immunoblotting with a 34-kDa nucleolar protein identified as fibrillarin. |
1(0,0,0,1) | Details |
| 7529293 | Takeuchi K, Turley SJ, Tan EM, Pollard KM: Analysis of the autoantibody response to fibrillarin in human disease and murine models of autoimmunity. J Immunol. 1995 Jan 15;154(2):961-71. Our results indicate that spontaneous human and toxin-induced murine autoantibodies to fibrillarin share common reactivity against this highly conserved nucleolar protein. Autoantibodies against fibrillarin can also be induced in H-2s mice by treatment with mercuric chloride (HgCl2). |
1(0,0,0,1) | Details |
| 9693280 | Johansson U, Hansson-Georgiadis H, Hultman P: The genotype determines the B cell response in mercury-treated mice. Int Arch Allergy Immunol. 1998 Aug;116(4):295-305. BACKGROUND: Mercury causes in mouse strains of the H-2s haplotype an autoimmune syndrome with antibodies to the nucleolar protein fibrillarin and systemic immune complex (IC) deposits. METHODS: During 4-7 weeks of subcutaneous mercuric chloride injections, the number of B cells and the expression of cell surface activation and proliferation markers was monitored by flow cytometry. |
1(0,0,0,1) | Details |
| 10497068 | Pearson DL, Reimonenq RD, Pollard KM: Expression and purification of recombinant mouse fibrillarin. . Protein Expr Purif. 1999 Oct;17(1):49-56. Fibrillarin is a 34-kDa nucleolar protein associated with many of the small nucleolar ribonucleoprotein (snoRNP) particles and plays a role in ribosomal RNA processing. |
1(0,0,0,1) | Details |
| 10942594 | Chen M, von Mikecz A: Specific inhibition of rRNA transcription and dynamic relocation of fibrillarin induced by mercury. Exp Cell Res. 2000 Aug 25;259(1):225-38. Here we report that environmentally relevant concentrations (5 microM) of inorganic mercury induce a redistribution of nucleolar protein fibrillarin from the nucleolus to the nucleoplasm in epithelial cell lines. |
1(0,0,0,1) | Details |