| Name | Na,K ATPases |
|---|---|
| Synonyms | (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1829408 | Lakshmi R, Kundu R, Thomas E, Mansuri AP: Mercuric chloride-induced inhibition of different ATPases in the intestine of mudskipper, Boleophthalmus dentatus. Ecotoxicol Environ Saf. 1991 Feb;21(1):18-24. |
88(1,1,2,3) | Details |
| 8396838 | Szumanska G, Gadamski R, Albrecht J: Changes of the Na/K ATPase activity in the cerebral cortical microvessels of rat after single intraperitoneal administration of mercuric chloride: histochemical demonstration with light and electron microscopy. Acta Neuropathol. 1993;86(1):65-70. In the present study, we tested the effect of mercuric chloride (HgCl2) on Na+/K+ ATPase activity, a key enzyme involved in the ion transport in and out of the brain. |
40(0,1,2,5) | Details |
| 1317120 | Anner BM, Moosmayer M, Imesch E: Mercury blocks Na-K-ATPase by a ligand-dependent and reversible mechanism. . Am J Physiol. 1992 May;262(5 Pt 2):F830-6. |
6(0,0,0,6) | Details |
| 10752519 | Deschenes G, Doucet A: Collecting duct (Na+/K+)-ATPase activity is correlated with urinary excretion in rat nephrotic syndromes. J Am Soc Nephrol. 2000 Apr;11(4):604-15. |
4(0,0,0,4) | Details |
| 2163123 | Musch MW, Chauncey B, Schmid EC, Kinne RK, Goldstein L: Mechanisms of mercurial and arsenical inhibition of absorption in intestine of the winter flounder Pseudopleuronectus americanus. Toxicol Appl Pharmacol. 1990 Jun 1;104(1):59-66. Effects of HgCl2 (100 microM) para-chloromercuribenzene sulfonate (PCMBS) (1 mM), and oxophenylarsine (OPA) (250 microM) were determined on (a) the rate of Na pump activity in intact winter flounder intestine; (b) activity of Na-K-ATPase in tissue homogenates; and (c) Na-dependent and Na-independent uptake of in brush border membrane vesicles. |
4(0,0,0,4) | Details |
| 2157424 | Anner BM, Moosmayer M, Imesch E: Chelation of mercury by ouabain-sensitive and ouabain-resistant renal Na,K-ATPase. Biochem Biophys Res Commun. 1990 Mar 30;167(3):1115-21. |
3(0,0,0,3) | Details |
| 2544041 | Hare MF, Minnema DJ, Cooper GP, Michaelson IA: Effects of mercuric chloride on [3H] release from rat brain striatal synaptosomes. Toxicol Appl Pharmacol. 1989 Jun 15;99(2):266-75. The effects of HgCl2 on transmitter release from amphibian neuromuscular junction preparations resemble those produced by the Na+, K+-ATPase inhibitor ouabain. |
3(0,0,0,3) | Details |
| 16189294 | Kim SW, de Seigneux S, Sassen MC, Lee J, Kim J, Knepper MA, Frokiaer J, Nielsen S: Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats. Am J Physiol Renal Physiol. 2006 Mar;290(3):F674-87. Epub 2005 Sep 27. Moreover, the abundance of the alpha-1 subunit of the Na-K-ATPase was decreased in the cortex/OSOM and ISOM but remained unchanged in the inner medulla. |
2(0,0,0,2) | Details |
| 1342826 | Oliveira EM, Vassallo DV: Effects of mercury on the contractility of isolated rat cardiac muscle. . Braz J Med Biol Res. 1992;25(10):1037-40. Since in several tissues including myocardium Hg2+ inhibits the activity of Ca2+ and Na (+)-K (+)-ATPases the results described here suggest that Hg2+, at lower concentrations, could increase force by inhibiting Na (+)-K (+)-ATPase, while at higher concentrations Hg2+ would decrease relative PRC potentiation by inhibiting sarcoplasmic reticulum Ca (2+)-ATPase. |
1(0,0,0,1) | Details |
| 2841777 | Klonne DR, Johnson DR: Enzyme activity and sulfhydryl status in rat renal cortex following mercuric chloride and administration. Toxicol Lett. 1988 Aug;42(2):199-205. The present studies investigated whether DTT, a sulfhydryl reducing agent, protected renal cortical sulfhydryl status in general, or the activity of various renal enzymes (Mg- and Na,K-ATPases, alkaline phosphatase, and peroxidase) in particular. |
1(0,0,0,1) | Details |
| 1342624 | Massaroni L, Oliveira EM, Stefanon I, Vassallo DV: Effects of mercury on the mechanical and electrical activity of the Langendorff-perfused rat heart. Braz J Med Biol Res. 1992;25(8):861-4. The inhibitory action of Hg2+ on ATP hydrolysis and on Ca2+ and Na (+)-K+ ATPases suggested to occur in other tissues could be the mechanism responsible for the observations reported here. |
1(0,0,0,1) | Details |
| 9344897 | Endo T, Kimura O, Sakata M, Shaikh ZA: Mercury uptake by LLC-PK1 cells: dependence on temperature and membrane potential. Toxicol Appl Pharmacol. 1997 Oct;146(2):294-8. Pretreatment of cells with 10 microM FCCP, a metabolic inhibitor and a ionophore, 0.5 mm DIDS, an anion transport inhibitor, or 0.5 mM ouabain, a Na+/K+-ATPase inhibitor, resulted in 72, 60, and 57% reduction in Hg uptake, respectively. |
1(0,0,0,1) | Details |
| 2844008 | Ballatori N, Shi C, Boyer JL: Altered plasma membrane ion permeability in mercury-induced cell injury: studies in hepatocytes of elasmobranch Raja erinacea. Toxicol Appl Pharmacol. 1988 Sep 15;95(2):279-91. The effects of HgCl2, CH3HgCl, p-chloromercuribenzene sulfonate (PCMBS), and CdCl2 on plasma membrane and cell metabolic functions of skate (Raja erinacea) hepatocytes in suspension culture were assessed by measuring (a) the rates of Na+-dependent and -independent L-[14C] uptake, (b) Na+-dependent 86Rb+ uptake, a measure of Na-K-ATPase activity, (c) 86Rb+ efflux, a measure of K+ permeability, (d) the difference between the 3H2O and [14C] inulin distribution spaces, a measure of intracellular water volume, (e) cellular ATP concentrations, and (f) (GSH) and levels. Mercuric chloride also impaired volume regulatory mechanisms in skate hepatocytes: cells treated with 50 microM HgCl2 swelled slowly over a 60-min interval to volumes nearly double those of control cells. |
1(0,0,0,1) | Details |
| 1753917 | Cronin RE, Thompson JR: Role of in the pathogenesis of acute renal failure. . Miner Electrolyte Metab. 1991;17(2):100-5. Chronic loading protects against mercuric chloride, uranyl and gentamicin models of acute renal failure. In the gentamicin model, protection is associated with a stimulation of renal cortical Na-K-ATPase activity and a reduction in the level of gentamicin accumulated in cortical tissue. |
1(0,0,0,1) | Details |