Protein Information

Name ICAM 1
Synonyms BB2; CD54; CD54 antigen; ICAM 1; ICAM1; Intercellular adhesion molecule 1; Intercellular adhesion molecule 1 precursor; Major group rhinovirus receptor…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
9933758 Nakahama H, Obata K, Matsuyama T, Sugita M, Horio M, Oka K, Moriyama T: Effect of a novel immunosuppressant, FK 506, on autoimmune glomerulonephritis in Brown Norway rats. Nephron. 1999 Feb;81(2):215-20.

Mercuric-chloride (HgCl2) induces a lymphoproliferative disorder and autoimmune glomerulonephritis in Brown Norway rats.
Immunofluorescence study showed a strong linear staining for IgG and the adhesion molecule ICAM-1 in all glomeruli.
1(0,0,0,1) Details
11884233 Jiang J, McCool BA, Parrish AR: Cadmium- and mercury-induced intercellular adhesion molecule-1 expression in immortalized proximal tubule cells: evidence for a role of decreased transforming growth factor-beta1. Toxicol Appl Pharmacol. 2002 Feb 15;179(1):13-20.

To investigate the impact of acute injury on the relationship between transforming growth factor-beta 1 (TGF-beta1) and intercellular adhesion molecule-1 (ICAM-1) expression, two immortalized mouse proximal tubular epithelial cell lines were exposed to cadmium chloride or mercuric chloride (0-50 microM) for 0-8 h.
12(0,0,1,7) Details
12675845 De Greef KE, Ysebaert DK, Persy V, Vercauteren SR, De Broe ME: ICAM-1 expression and leukocyte accumulation in inner stripe of outer medulla in early phase of ischemic compared to HgCl2-induced ARF. Kidney Int. 2003 May;63(5):1697-707.

7(0,0,0,7) Details
15494542 Pollard KM, Arnush M, Hultman P, Kono DH: Costimulation requirements of induced murine systemic autoimmune disease. . J Immunol. 2004 Nov 1;173(9):5880-7.


A number of receptor/ligand pairs have been shown to mediate costimulation, including CD28/B7 molecules (CD80 and CD86), CD40/CD40 ligand (CD40L, CD154), and LFA-1 (CD18)/ICAM-1 (CD54).
3(0,0,0,3) Details
10972676 Ghielli M, Verstrepen WA, De Greef KE, Helbert MH, Ysebaert DK, Nouwen EJ, De Broe ME: Antibodies to both ICAM-1 and LFA-1 do not protect the kidney against toxic (HgCl2) injury. Kidney Int. 2000 Sep;58(3):1121-34.

METHODS: Female Wistar rats were injected with monoclonal antibodies (mAbs) directed to both the leukocyte function-associated antigen 1 (LFA-1) and the intercellular adhesion molecule 1 (ICAM-1).
Doses (6 mg/kg of each mAb) were given 24 hours prior to the induction of acute tubular necrosis (ATN) by mercuric chloride administration (2 mg/kg, subcutaneously, day 0) and subsequently every 48 hours.
3(0,0,0,3) Details
9790309 Roos A, Claessen N, Schilder-Tol EJ, Weening JJ, Aten J: Differential expression of T-cell adhesion molecules and LFA-1-dependent intercellular adhesion in HgCl2-induced autoimmunity and immune suppression. Scand J Immunol. 1998 Oct;48(4):389-96.


HgCl2 was previously found to enhance expression of LFA-1, ICAM-1 and CD134 (OX40) on T cells in BN rats.
2(0,0,0,2) Details
8633208 Roos A, Claessen N, Weening JJ, Aten J: Enhanced T lymphocyte expression of LFA-1, ICAM-1, and the TNF receptor family member OX40 in HgCl2-induced systemic autoimmunity. Scand J Immunol. 1996 May;43(5):507-18.

Injection of mercuric chloride into Brown Norway (BN) rats induces a T lymphocyte-dependent autoimmune syndrome.
2(0,0,0,2) Details
10095178 Nakahama H, Obata K, Sugita M, Horio M, Oka K, Moriyama T: Effect of FK 506 in the treatment of autoimmune glomerulonephritis in Brown Norway rats. Nephron. 1999;81(4):421-7.

Immunofluorescence study showed strong linear staining for IgG and the adhesion molecule ICAM-1 in all glomeruli.
Mercuric chloride (HgCl2) induces a lymphoproliferative disorder and autoimmune glomerulonephritis in Brown Norway (BN) rats.
1(0,0,0,1) Details
11359392 Little MC, Watson RE, Pemberton MN, Griffiths CE, Thornhill MH: Activation of oral keratinocytes by mercuric chloride: relevance to dental amalgam-induced oral lichenoid reactions. Br J Dermatol. 2001 May;144(5):1024-32.

ICAM-1 expression and the release of cytokines was determined by enzyme-linked immunosorbent assay techniques.
1(0,0,0,1) Details