Protein Information

Name AQP4
Synonyms AQP 4; AQP4; Aquaporin 4; HMIWC 2; HMIWC2; MIWC; Mercurial insensitive water channel; WCH 4…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
18167118 Yukutake Y, Tsuji S, Hirano Y, Adachi T, Takahashi T, Fujihara K, Agre P, Yasui M, Suematsu M: Mercury chloride decreases the water permeability of aquaporin-4-reconstituted proteoliposomes. Biol Cell. 2008 Jun;100(6):355-63.

8(0,0,0,8) Details
8555225 Shi LB, Verkman AS: Selected cysteine point mutations confer mercurial sensitivity to the mercurial-insensitive water channel MIWC/AQP-4. Biochemistry. 1996 Jan 16;35(2):538-44.

6(0,0,0,6) Details
9369468 Kuwahara M, Gu Y, Ishibashi K, Marumo F, Sasaki S: Mercury-sensitive residues and pore site in AQP3 water channel. Biochemistry. 1997 Nov 18;36(46):13973-8.


Water channel function of all aquaporins (AQPs) but AQP4 can be inhibited by mercurial reagents.
1(0,0,0,1) Details
9829975 Meinild AK, Klaerke DA, Zeuthen T: Bidirectional water fluxes and specificity for small hydrophilic molecules in aquaporins 0-5. J Biol Chem. 1998 Dec 4;273(49):32446-51.


The reflection coefficients (sigma) of urea, glycerol, acetamide, and formamide at 23 degreesC were: AQP0: 1, 1, 0.8, 0.6; AQP1: 1, 0.8, 1, 1; AQP2: 1, 0.8, 1, 1; AQP3: 1, 0.2, 0.7, 0.4; AQP4: 1, 0.9, 1, 1; and AQP5: 1, 1, 1, 0.8.
1(0,0,0,1) Details
18344486 Philip BN, Yi SX, Elnitsky MA, Lee RE Jr: Aquaporins play a role in desiccation and freeze tolerance in larvae of the goldenrod gall fly, Eurosta solidaginis. J Exp Biol. 2008 Apr;211(Pt 7):1114-9.

Immunoblotting with mammalian anti-AQP2, -AQP3 and -AQP4 revealed corresponding aquaporin homologues in E. solidaginis, whose patterns of expression varied depending on acclimation temperature and desiccation treatment.
To examine the role of aquaporins in freeze tolerance, we froze fat body, midgut and salivary gland tissues in the presence and absence of mercuric chloride, an aquaporin inhibitor.
1(0,0,0,1) Details