Protein Information

Name acid phosphatase
Synonyms ACP 3; PAP; ACP3; ACPP; ACPP protein; Acid phosphatase; Acid phosphatase prostate nirs variant 1; PACP…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
19576259 Rao MV, Chhunchha B: Protective role of melatonin against the mercury induced oxidative stress in the rat thyroid. Food Chem Toxicol. 2010 Jan;48(1):7-10. Epub 2009 Jul 1.

Present study investigated the protective role of melatonin (MLT, 5mg/kg body wt., ip) against the long term effects of mercuric chloride (MC; 2 and 4 mg/kg body wt., po) in the thyroid gland of the rats through certain antioxidative indices like superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione (GSH), catalase (CAT) and lipid peroxidation (LPO), other biochemical parameters such as succinate dehydrogenase (SDH), adenosine triphosphatase (ATPase), acid phosphatase (ACPase) and alkaline phosphatase (ALPase) were also measured.
6(0,0,1,1) Details
17041551 Jagadeesan G, Kavitha AV: Recovery of phosphatase and transaminase activity of mercury intoxicated Mus musculus (Linn.) liver tissue by Tribulus terrestris (Linn.) (Zygophyllaceae) extract. Trop Biomed. 2006 Jun;23(1):45-51.

At a median-lethal dose of mercuric chloride (12.9 mg/kg body wt.) administration an enhanced level of glutamate oxaloacete transaminase (GOT), glutamate pyruvate transminase (GPT) and simultaneously decreased level of acid phosphatase (ACP) and alkaline phosphatase (ALT) activities were noticed in the liver.
6(0,0,1,1) Details
20307147 Rao MV, Purohit A, Patel T: Melatonin protection on mercury-exerted brain toxicity in the rat. Drug Chem Toxicol. 2010 Apr;33(2):209-16.

The effect of melatonin on the neurotoxicity induced by mercuric chloride was studied.
The results suggest that the graded doses of mercury elicit the depletion of enzymatic activities, such as adenosine triphosphatase, succinate dehydrogenase, phosphorylase, alkaline phosphatase, acid phosphatase, altered glycogen, total protein, and lipid peroxidation levels in the cerebral hemisphere, cerebellum, and medulla oblongata of the brain, thereby affecting their respective functions.
1(0,0,0,1) Details
17215067 Sharma MK, Sharma A, Kumar A, Kumar M: Evaluation of protective efficacy of Spirulina fusiformis against mercury induced nephrotoxicity in Swiss albino mice. Food Chem Toxicol. 2007 Jun;45(6):879-87. Epub 2006 Nov 23.

Spirulina extract was administered orally. (iv) Combination group--S. fusiformis was administered 10 days before mercuric chloride administration and continued upto 30 days after mercuric chloride administration (5.0 mg/kg b.wt.).
The animals were autopsied on 1, 3, 7, 15 and 30 days after treatment and the activity of alkaline phosphatase (ALP), acid phosphatase (ACP), lactate dehydrogenase (LDH) and MDA (malondialdehyde) level were measured in kidney homogenates.
1(0,0,0,1) Details
10433380 Chapman LA, Chan HM: Inorganic mercury pre-exposures protect against methyl mercury toxicity in NSC-34 (neuron x spinal cord hybrid) cells. Toxicology. 1999 Feb 15;132(2-3):167-78.

To mimic the increase in Hg2+ in the mammalian brain with long term MeHg exposure, the cells were treated with 1 microM mercuric chloride (HgCl2) for five passages before exposure to MeHgCl (1-16 microM) for 48 h.
MeHgCl toxicity was measured by trypan blue exclusion, reduction of resazurin dye and acid phosphatase activity.
1(0,0,0,1) Details
3238422 Patel B, Chandy JP, Patel S: Do selenium and glutathione inhibit the toxic effects of mercury in marine lamellibranchs?. Sci Total Environ. 1988 Oct 15;76(2-3):147-65.


The activities of lysosomal enzymes--arylsulfatase, acid phosphatase, beta-galactosidase and beta-glucuronidase--varied considerably.
1(0,0,0,1) Details
2606523 Bhattacharya T, Bhattacharya S, Ray AK, Dey S: Influence of industrial pollutants on thyroid function in Channa punctatus (Bloch). Indian J Exp Biol. 1989 Jan;27(1):65-8.

A 30 day exposure of C. punctatus to sublethal levels of phenol, ammonia, mercuric chloride, cadmium chloride and a mixture of the four resulted in an overall activation of guaiacol peroxidase and depression of iodide peroxidase (IPOD) activity and blood T4 titre.
Alterations in acid phosphatase (AP) activity indicate changes in the lysosomal membrane characteristics caused by these toxicants.
1(0,0,0,1) Details
18627859 Raes BB: The ultrastructural effect and subcellular localization of mercuric chloride and methylmercuric chloride in insect cells (Aedes albopictusC6/36). Tissue Cell. 1999 May;31(2):223-32.

At sublethal concentrations, Hg inhibited the lysosomal marker enzyme acid phosphatase to some extent.
1(0,0,0,1) Details