Protein Information

Name fibronectin
Synonyms CIG; MSF; Cold insoluble globulin; FINC; FN; FN1; Fibronectin; Fibronectin 1…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
11768240 Saball E, Salvarrey M, Serra E, Pico G, Elias MM: Potential mechanism of fibronectin deposits in acute renal failure induced by mercuric chloride. Mol Cell Biochem. 2001 Oct;226(1-2):67-75.
37(0,1,2,2) Details
9062849 Girardi G, Saball DE, Salvarrey MS, Elias MM: Glomerular compromise in mercuric chloride-induced nephrotoxicity. J Biochem Toxicol. 1996;11(4):189-96.

Renal sections prepared for immunohistochemical and histochemical analysis showed larger deposits of fibronectin and lipids and enhanced cellularity in glomerular structures from HgCl2-treated rats.
2(0,0,0,2) Details
10469268 Suzuki K, Uetsuka K, Nakayama H, Doi K: Kinetics of transforming growth factor-beta1 and extracellular matrix in renal tubulointerstitial lesions of mercuric chloride-treated Brown Norway rats. Int J Exp Pathol. 1999 Jun;80(3):125-32.

In the ECM, deposition of fibronectin was prominent throughout the experimental period.
1(0,0,0,1) Details
9773789 Escudero E, Nieto M, Martin A, Molina A, Lobb RR, Sanchez-Madrid F, Mampaso F: Differential effects of antibodies to vascular cell adhesion molecule-1 and distinct epitopes of the alpha4 integrin in HgCl2-induced nephritis in Brown Norway rats. J Am Soc Nephrol. 1998 Oct;9(10):1881-91.


It was found that B1 and B2 anti-alpha4 mAb completely block adhesion to fibronectin, but the inhibition of adhesion to vascular cell adhesion molecule-1 (VCAM-1) with HP2/1 mAb was lower than with HP2/4 mAb.
1(0,0,0,1) Details
1688961 Makker SP, Kanalas JJ: Renal antigens in mercuric chloride induced, anti-GBM autoantibody glomerular disease. Kidney Int. 1990 Jan;37(1):64-71.

By enzyme-linked immunosorbent assay (ELISA) the anti-GBM-Ab reacted with laminin, type IV collagen, collagenase-resistant noncollagenous portion of glomerular basement membrane (GBM), saline soluble proteins of kidney cortex homogenate and fibronectin.
1(0,0,0,1) Details
11168634 Roos A, Neeft M, Engelen L, Schilder-Tol EJ, Kunzendorf U, Weening JJ, Aten J: The immune dysregulatory compound mercuric chloride induces integrin-mediated T-lymphocyte adhesion. Immunology. 2001 Jan;102(1):31-8.

Exposure of a human T-cell clone to HgCl2 for 1 hr enhanced, in a dose-dependent way, cell binding to fibronectin (FN) and to intercellular adhesion molecules (ICAM) -1, -2 and -3.
1(0,0,0,1) Details
12790667 Xiao C, Luong JH: On-line monitoring of cell growth and cytotoxicity using electric cell-substrate impedance sensing (ECIS). Biotechnol Prog. 2003 May-Jun;19(3):1000-5.


Attachment, spreading and proliferation of V79 fibroblastic cells cultured on a microarray of small gold electrodes precoated with fibronectin were detected as resistance changes.
1(0,0,0,1) Details
1718461 Bachmann M, Chang S, Bernd A, Mayet W, Meyer zum Buschenfelde KH, Muller WE: Translocation of the nuclear autoantigen La to cell surface: assembly and disassembly with the extracellular matrix. Autoimmunity. 1991;9(2):99-107.

In addition we found that a minor part of La antigen associates with the extracellular fibronectin network.
Incubation of serum starved cells with mercuric chloride, a known potent inducer of autoantibodies, also resulted in a detachment of the extracellular matrix associated La protein.
1(0,0,0,1) Details
20353040 Yuan JL, Zhang Y, Jiang ZH: [Effects of fuzheng huayu recipe in antagonizing rat's renal interstitial fibrosis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Jan;30(1):76-9.

OBJECTIVE: To observe the effects of Fuzheng Huayu Recipe (FHR) on rat's renal interstitial fibrosis induced by mercuric chloride (HgCl2), and to explore preliminarily its mechanism of action.
Serum creatinine (Cr) and urea nitrogen (BUN) content were tested with corresponding test kits; hydroxyproline (Hyp) content in kidney was assayed with hydrochloric acid hydrolysis; renal histologic change was observed with HE, Masson and methenamine silver (PASM) staining; and collagen type I (Col I), as well as protein expressions of fibronectin (FN) and alpha-smooth muscle actin (alpha-SMA) was determined with Western blot.
1(0,0,0,1) Details
9853004 Girardi G, Elias MM: Verapamil protection against mercuric chloride-induced renal glomerular injury in rats. Toxicol Appl Pharmacol. 1998 Oct;152(2):360-5.

Renal sections prepared for immunohistochemical detection and histochemical analysis showed increased deposits of fibronectin and lipids and enhanced cellularity in glomerular structures from HgCl2-treated rats.
1(0,0,0,1) Details
1591888 Aten J, Veninga A, Bruijn JA, Prins FA, de Heer E, Weening JJ: Antigenic specificities of glomerular-bound autoantibodies in membranous glomerulopathy induced by mercuric chloride. Clin Immunol Immunopathol. 1992 Apr;63(1):89-102.

0(0,0,0,0) Details