| Name | B cell growth factor |
|---|---|
| Synonyms | B cell differentiation factor gamma; B cell growth factor; B cell stimulatory factor 1; BCDF gamma; BCDFg; BCDFgamma; BCGF; BSF 1… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 10359893 | Dastych J, Walczak-Drzewiecka A, Wyczolkowska J, Metcalfe DD: Murine mast cells exposed to mercuric chloride release granule-associated N-acetyl-beta-D-hexosaminidase and secrete IL-4 and TNF-alpha. J Allergy Clin Immunol. 1999 Jun;103(6):1108-14. |
85(1,1,1,5) | Details |
| 7657819 | Prigent P, Saoudi A, Pannetier C, Graber P, Bonnefoy JY, Druet P, Hirsch F: Mercuric chloride, a chemical responsible for T helper cell (Th) 2-mediated autoimmunity in brown Norway rats, directly triggers T cells to produce interleukin-4. J Clin Invest. 1995 Sep;96(3):1484-9. |
84(1,1,1,4) | Details |
| 10886234 | Gorrie MJ, Qasim FJ, Whittle CJ, Gillespie KM, Szeto CC, Nicoletti F, Bolton EM, Bradley JA, Mathieson PW: Exogenous type-1 cytokines modulate mercury-induced hyper-IgE in the rat. Clin Exp Immunol. 2000 Jul;121(1):17-22. In susceptible rat strains, mercuric chloride (HgCl2) induces activation of Th2 cells, with enhanced expression of IL-4, polyclonal B cell activation and very high levels of circulating IgE. |
82(1,1,1,2) | Details |
| 10861847 | Du J, Suzuki H, Nagase F, Akhand AA, Yokoyama T, Nakashima I: Mercuric chloride stimulates distinct signal transduction pathway for DNA synthesis in a T-cell line, CTLL-2. J Cell Biochem. 2000 Jun 6;78(3):500-8. Addition of anti-IL-2 or anti-IL-4 antibody to the culture, which neutralized all of the IL-2 or IL-4 activity, respectively, never inhibited the mercuric chloride-mediated DNA synthesis. |
81(1,1,1,1) | Details |
| 10350151 | Walczak-Drzewiecka A, Slusarczyk A, Wyczolkowska J, Dastych J: Mercuric chloride synergistically increases ionophore-induced secretion of IL-4 from murine mast cells. Inflamm Res. 1999 Apr;48 Suppl 1:S35-6. |
81(1,1,1,1) | Details |
| 14738445 | Wu Z, Holwill SD, Oliveira DB: Desferrioxamine modulates chemically induced T helper 2-mediated autoimmunity in the rat. Clin Exp Immunol. 2004 Feb;135(2):194-9. A rise in interleukin (IL) 4-dependent immunoglobulin E (IgE) is a hallmark of the mercuric chloride (HgCl2)-induced Th2-mediated autoimmune syndrome in the Brown Norway (BN) rat, and one of the mediators in allergic asthma in human. |
33(0,1,1,3) | Details |
| 19462287 | Penna S, Pocino M, Marval MJ, Lloreta J, Gallardo L, Vila J: Modifications in rat testicular morphology and increases in IFN-gamma serum levels by the oral administration of subtoxic doses of mercuric chloride. Syst Biol Reprod Med. 2009 Mar-Apr;55(2):69-84. In order to analyze testicular and epididymal morphological alterations and changes in IL-4 or IFN-gamma serum levels, adult male Sprague-Dawley rats received 0.01, 0.05 or 0.1 microg/ml of mercuric chloride (HgCl (2)) in deionized water for 1 to 7 months by oral route. |
6(0,0,1,1) | Details |
| 9764596 | Bagenstose LM, Salgame P, Monestier M: Mercury-induced autoimmunity in the absence of IL-4. . Clin Exp Immunol. 1998 Oct;114(1):9-12. In susceptible H-2S mice, mercuric chloride (HgCl2) induces an autoimmune syndrome characterized by production of anti-nucleolar antibodies (ANoA) and increased serum levels of IgG1 and IgE antibodies. |
4(0,0,0,4) | Details |
| 10886398 | Szeto C, Gillespie KM, Mathieson PW: Levamisole induces interleukin-18 and shifts type 1/type 2 cytokine balance. Immunology. 2000 Jun;100(2):217-24. Further, the type 2 response induced in BN rats by mercuric chloride was markedly attenuated when rats were pretreated with levamisole: there was a 2-log reduction in maximum serum IgE level and marked attenuation of IL-4 gene upregulation. |
32(0,1,1,2) | Details |
| 8918574 | Kiely PD, O'Brien D, Oliveira DB: Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity. Clin Exp Immunol. 1996 Nov;106(2):280-5. Mercuric chloride (HgCl2) induces a T cell-dependent autoimmune syndrome in Brown-Norway (BN) rats characterized by a humoral response, tissue injury with an accumulation of CD8+ and CD4+ T cells, and an increase in tissue IL-4 mRNA and serum IgE suggesting Th2 cell activation. |
31(0,1,1,1) | Details |
| 11222498 | Wu Z, Turner DR, Oliveira DB: IL-4 gene expression up-regulated by mercury in rat mast cells: a role of oxidant stress in IL-4 transcription. Int Immunol. 2001 Mar;13(3):297-304. In the Brown Norway (BN) rat, chemical compounds [mercuric chloride (HgCl2), D-penicillamine or gold salts] induce a T (h) 2-dominated autoimmune syndrome with tissue injury in the form of a vasculitis and arthritis. |
9(0,0,0,9) | Details |
| 15032693 | Wu Z, MacPhee IA, Oliveira DB: Reactive species in the initiation of IL-4 driven autoimmunity as a potential therapeutic target. Curr Pharm Des. 2004;10(8):899-913. Mercuric chloride probably causes oxidant stress by the generation of free-radicals, activating NK-kappaB, a transcription factor for the IL-4 gene. |
8(0,0,1,3) | Details |
| 8560497 | Warbrick EV, Thomas AL, Coleman JW: The effects of mercuric chloride on growth, cytokine and MHC class II gene expression in a human leukemic mast cell line. Toxicology. 1995 Dec 15;104(1-3):179-86. We have examined the effects of mercuric chloride (HgCl2) on growth and IL-4, IL-8, TNF-alpha and MHC class II gene expression in the HMC-1 human leukemic mast cell line. |
8(0,0,1,3) | Details |
| 9405450 | Badou A, Savignac M, Moreau M, Leclerc C, Pasquier R, Druet P, Pelletier L: HgCl2-induced interleukin-4 gene expression in T cells involves a protein kinase C-dependent influx through L-type channels. J Biol Chem. 1997 Dec 19;272(51):32411-8. Mercuric chloride (HgCl2) induces T helper 2 (Th2) autoreactive anti-class II T cells in Brown Norway rats. |
4(0,0,0,4) | Details |
| 18075863 | de Vos G, Abotaga S, Liao Z, Jerschow E, Rosenstreich D: Selective effect of mercury on Th2-type cytokine production in humans. Immunopharmacol Immunotoxicol. 2007;29(3-4):537-48. Mercury induces autoimmune disease and increases IL-4 production and IgE levels in certain rodent strains. Human peripheral blood mononuclear cells (PBMC) were incubated with PMA/ionomycin or Con A in the presence or absence of methyl mercury (CH (3) Hg) or mercuric chloride (HgCl (2)). |
4(0,0,0,4) | Details |
| 8898950 | Gillespie KM, Saoudi A, Kuhn J, Whittle CJ, Druet P, Bellon B, Mathieson PW: Th1/Th2 cytokine gene expression after mercuric chloride in susceptible and resistant rat strains. Eur J Immunol. 1996 Oct;26(10):2388-92. We have previously shown, by fully quantitative polymerase chain reaction (PCR), up-regulation of interleukin-4 (IL-4) gene expression in HgCl2-treated BN rats, implicating Th2 cells in the autoimmune syndrome. |
3(0,0,0,3) | Details |
| 8757348 | Ramanathan S, de Kozak Y, Saoudi A, Goureau O, Van der Meide PH, Druet P, Bellon B: Recombinant IL-4 aggravates experimental autoimmune uveoretinitis in rats. J Immunol. 1996 Sep 1;157(5):2209-15. |
10(0,0,0,10) | Details |
| 9182889 | Qasim FJ, Thiru S, Gillespie K: Gold and D-penicillamine induce vasculitis and up-regulate mRNA for IL-4 in the Brown Norway rat: support for a role for Th2 cell activity. Clin Exp Immunol. 1997 Jun;108(3):438-45. DP, gold salts and mercuric chloride (HgCl2) are known to induce Th2-dominated autoimmune syndromes in genetically susceptible rodent strains, and we have demonstrated recently that HgCl2 up-regulates messenger RNA (mRNA) for IL-4 in the Brown Norway (BN) rat. |
10(0,0,1,5) | Details |
| 2016536 | Ochel M, Vohr HW, Pfeiffer C, Gleichmann E: IL-4 is required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride. J Immunol. 1991 May 1;146(9):3006-11. |
10(0,0,1,5) | Details |
| 7871386 | Gillespie KM, Qasim FJ, Tibbatts LM, Thiru S, Oliveira DB, Mathieson PW: Interleukin-4 gene expression in mercury-induced autoimmunity. Scand J Immunol. 1995 Mar;41(3):268-72. Mercuric chloride (HgCl2) induces autoimmunity in Brown Norway (BN) rats, with necrotizing vasculitis in the gut. |
7(0,0,0,7) | Details |
| 19604304 | Wu Z, Pearson A, Oliveira D: Characterization of cis-regulatory elements conferring mercury-induced interleukin-4 gene expression in rat mast cells: a role for signal transducer and activator of transcription 6 and TATA box binding sites. Immunology. 2009 Aug;127(4):530-8. We have previously shown that oxidative stress is involved in the pathogenesis of a mercuric chloride (HgCl (2))-induced, T helper type 2 (Th2)-driven autoimmune syndrome in Brown Norway (BN) rats. |
7(0,0,0,7) | Details |
| 7586682 | Coers W, Vos JT, Van der Meide PH, Van der Horst ML, Huitema S, Weening JJ: Interferon-gamma (IFN-gamma) and IL-4 expressed during mercury-induced membranous nephropathy are toxic for cultured podocytes. Clin Exp Immunol. 1995 Nov;102(2):297-307. |
7(0,0,0,7) | Details |
| 8102566 | van Vliet E, Uhrberg M, Stein C, Gleichmann E: MHC control of IL-4-dependent enhancement of B cell Ia expression and Ig class switching in mice treated with mercuric chloride. Int Arch Allergy Immunol. 1993;101(4):392-401. |
6(0,0,1,1) | Details |
| 9536116 | Roos A, Schilder-Tol EJ, Chand MA, Claessen N, Lakkis FG, Pascual DW, Weening JJ, Aten J: Differential regulation of expression of the MHC class II molecules RT1.B and RT1.D on rat B lymphocytes: effects of interleukin-4, interleukin-13 and interferon-gamma. Immunology. 1998 Jan;93(1):33-40. Brown Norway (BN) rats exposed to mercuric chloride develop a Th2-dependent systemic autoimmunity, whereas Lewis rats, which are highly susceptible to Th1-mediated autoimmunity, develop immune suppression after mercuric chloride exposure. |
3(0,0,0,3) | Details |
| 11867563 | Wu Z, Turner DR, Oliveira DB: Antioxidants inhibit mercuric chloride-induced early vasculitis. . Int Immunol. 2002 Mar;14(3):267-73. We have shown in vitro that oxidative stress up-regulates IL-4 in mast cells and predisposes to degranulation. |
3(0,0,0,3) | Details |
| 9647229 | Kono DH, Balomenos D, Pearson DL, Park MS, Hildebrandt B, Hultman P, Pollard KM: The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance. J Immunol. 1998 Jul 1;161(1):234-40. To further define their roles in systemic autoimmunity, IL-4 and IFN-gamma gene knockout mice were studied for susceptibility to the prototypic Th2-mediated mercury-induced autoimmunity. |
3(0,0,0,3) | Details |
| 7647579 | Kubicka-Muranyi M, Griem P, Lubben B, Rottmann N, Luhrmann R, Gleichmann E: Mercuric-chloride-induced autoimmunity in mice involves up-regulated presentation by spleen cells of altered and unaltered nucleolar self antigen. Int Arch Allergy Immunol. 1995 Sep;108(1):1-10. Four fibrillarin-specific hybridoma clones studied for cytokine production were shown to produce interleukin (IL)-2, and three of them also produced IL-4. |
1(0,0,0,1) | Details |
| 9142228 | Roos A, Schilder-Tol EJ, Chand MA, Weening JJ, Aten J: HgCl2 and IL4 differentially modify expression of major histocompatibility complex class II molecules RT1.B and RT1.D in B lymphocytes from brown Norway and Lewis rats. Transplant Proc. 1997 May;29(3):1675-6. |
1(0,0,0,1) | Details |
| 15720444 | Hansson M, Djerbi M, Rabbani H, Mellstedt H, Gharibdoost F, Hassan M, Depierre JW, Abedi-Valugerdi M: Exposure to mercuric chloride during the induction phase and after the onset of collagen-induced arthritis enhances immune/autoimmune responses and exacerbates the disease in DBA/1 mice. Immunology. 2005 Mar;114(3):428-37. Furthermore, while animals injected with mercury alone exhibited a significant decrease in the ratio of the levels of interferon-gamma (IFN-gamma) to interleukin-4 (IL-4) mRNA in their spleens, this ratio was increased in mice with CIA, with or without administration of mercury. |
1(0,0,0,1) | Details |
| 12490134 | Jin GB, Inoue S, Urano T, Cho S, Ouchi Y, Cyong JC: Induction of anti-metallothionein antibody and mercury treatment decreases bone mineral density in mice. Toxicol Appl Pharmacol. 2002 Dec 1;185(2):98-110. Similar results were also observed in splenic secretions of IL-4 and IL-10 based on anti-CD3 Ab stimulation. Mercuric chloride (HgCl2) is an industrial agent with toxic effects on the immune system, kidney, lung, and nervous tissue, but little is known about its effect on bone. |
1(0,0,0,1) | Details |
| 16237113 | Zheng Y, Gallucci S, Gaughan JP, Gross JA, Monestier M: A role for B cell-activating factor of the TNF family in chemically induced autoimmunity. J Immunol. 2005 Nov 1;175(9):6163-8. In this study, we observe that HgCl2 administration in susceptible mice results in the elevated production of B cell-activating factor of the TNF family ((BAFF) also known as BLyS, TALL-1, zTNF-4, THANK, and TNSF13B), a B cell growth factor belonging to the TNF family. |
1(0,0,0,1) | Details |
| 9135547 | Hu H, Abedi-Valugerdi M, Moller G: Pretreatment of lymphocytes with mercury in vitro induces a response in T cells from genetically determined low-responders and a shift of the interleukin profile. Immunology. 1997 Feb;90(2):198-204. We found that in vitro mercuric chloride induced a high proliferative response in spleen lymphocytes from mercury-susceptible SJL mice, but a low response in resistant mice, such as C57BL/6 (H-2b), A/J (H-2a) and CBA (H-2k) mice. In contrast, by pretreating the cells with mercury and then washing, spleen cells from both high and low-responder mice produced IL-4. |
1(0,0,0,1) | Details |
| 17302730 | Hemdan NY, Lehmann I, Wichmann G, Lehmann J, Emmrich F, Sack U: Immunomodulation by mercuric chloride in vitro: application of different cell activation pathways. Clin Exp Immunol. 2007 May;148(2):325-37. Epub 2007 Feb 14. Doses up to 0.150 and 0.5 microg/ml increased IL-10 and IL-4 production, respectively, resulting in significantly reduced Th1/Th2 ratios. |
1(0,0,0,1) | Details |
| 14616778 | Haggqvist B, Hultman P: Effects of deviating the Th2-response in murine mercury-induced autoimmunity towards a Th1-response. Clin Exp Immunol. 2003 Nov;134(2):202-9. Injections of both rIL-12 and anti-IL-4 monoclonal antibody (alpha-IL-4) reduced the HgCl2-(Hg-) induced concentration of the Th2-dependent serum IgE and IgG1, but increased the Th1-dependent serum IgG2a. |
1(0,0,0,1) | Details |
| 11334498 | Fournie GJ, Mas M, Cautain B, Savignac M, Subra JF, Pelletier L, Saoudi A, Lagrange D, Calise M, Druet P: Induction of autoimmunity through bystander effects. J Autoimmun. 2001 May;16(3):319-26. In vitro, both activate signal transduction pathways that result in the expression of cytokines, particularly of IL-4 and IFNgamma. |
1(0,0,0,1) | Details |
| 15588918 | Ringerike T, Ulleras E, Volker R, Verlaan B, Eikeset A, Trzaska D, Adamczewska V, Olszewski M, Walczak-Drzewiecka A, Arkusz J, van Loveren H, Nilsson G, Lovik M, Dastych J, Vandebriel RJ: Detection of immunotoxicity using T-cell based cytokine reporter cell lines ("Cell Chip"). Toxicology. 2005 Jan 15;206(2):257-72. We used this prototype "Cell Chip" to test, by means of flow cytometry, the immunomodulatory potential of 13 substances and were able to detect changes in cytokine expression in 12 cases (successful for cyclosporine, rapamycin, pentamidine, thalidomide, bis (tri-n-butyltin) oxide, house dust mite allergen (Der p I), 1-chloro-2,4-dinitrobenzene, tolylene 2,4-diisocyanate, tetrachloroplatinate, and mercuric chloride; unsuccessful for penicillin G). The T-cell lymphoma cell line EL-4 was transfected with the regulatory sequences of interleukin (IL)-2, IL-4, IL-10, interferon (IFN)-gamma or actin fused to the gene for enhanced green fluorescent protein (EGFP) in either a stabile or a destabilised form. |
1(0,0,0,1) | Details |
| 9218838 | Doth M, Fricke M, Nicoletti F, Garotta G, Van Velthuysen ML, Bruijn JA, Gleichmann E: Genetic differences in immune reactivity to mercuric chloride (HgCl2): immunosuppression of H-2d mice is mediated by interferon-gamma (IFN-gamma). Clin Exp Immunol. 1997 Jul;109(1):149-56. These findings further strengthen the concept that B10.S mice react to HgCl2 by preferential activation of their Th2 cells producing IL-4, whereas B10.D2 mice react to HgCl2 by preferential activation of their Th1 cells, which produce IFN-gamma and thus suppress antibody responses. |
1(0,0,0,1) | Details |
| 8478610 | Mathieson PW, Thiru S, Oliveira DB: Regulatory role of OX22high T cells in mercury-induced autoimmunity in the brown Norway rat. J Exp Med. 1993 May 1;177(5):1309-16. The monoclonal antibody OX22 defines a functional split within CD4+ T cells in the rat, with OX22high cells mainly producing interleukin 2 (IL-2) and interferon gamma and responsible for delayed-type hypersensitivity responses, and OX22low cells mainly producing IL-4 and -5 and responsible for providing B cell help. We have used OX22 in vivo to define the role of these subsets in mercuric chloride-induced autoimmunity in the Brown Norway rat. |
1(0,0,0,1) | Details |
| 19678760 | Pilones K, Tatum A, Gavalchin J: Gestational exposure to mercury leads to persistent changes in T-cell phenotype and function in adult DBF1 mice. J Immunotoxicol. 2009 Sep;6(3):161-70. In particular, the production of IL-4 and IFN by ConA-stimulated splenocytes from mercury-exposed male and female mice was significantly increased, while IL-2 and IL-10 levels were unaffected. After overnight breeding to DBA/1 males, pregnant BALB/c dams were given either mercuric chloride in drinking water at 10 mg/L ad libitum for the duration of gestation or plain water. |
1(0,0,0,1) | Details |
| 7589090 | Kiely PD, Gillespie KM, Oliveira DB: Oxpentifylline inhibits tumor necrosis factor-alpha mRNA transcription and protects against arthritis in mercuric chloride-treated brown Norway rats. Eur J Immunol. 1995 Oct;25(10):2899-906. In two separate experiments, OXP significantly enhanced unstimulated levels of splenic interleukin-4 (IL-4) mRNA (median 62%, of an artificial IL-4 mRNA construct, vs. 36.5% in controls) and in one experiment, exaggerated the total IgE response to HgCl2. |
1(0,0,0,1) | Details |
| 20049214 | Gardner RM, Nyland JF, Evans SL, Wang SB, Doyle KM, Crainiceanu CM, Silbergeld EK: Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro. Environ Health Perspect. 2009 Dec;117(12):1932-8. Epub 2009 Aug 19. IL-4, IL-17, and interferon-gamma increased in a concentration-response manner. PBMCs were cultured with lipopolysaccharide and concentrations of mercuric chloride (HgCl (2)) up to 200 nM. |
1(0,0,0,1) | Details |
| 11737666 | Bagenstose LM, Mentink-Kane MM, Brittingham A, Mosser DM, Monestier M: Mercury enhances susceptibility to murine leishmaniasis. . Parasite Immunol. 2001 Dec;23(12):633-40. Susceptible mice develop a T-helper type 2 (Th2)-type immune response following infection distinguished by the development of interleukin (IL)-4 secreting T cells in the lymph node and spleen. We show that subtoxic doses of mercuric chloride (HgCl2) exacerbate disease outcome in SJL mice resulting in increased footpad swelling and increased parasite burdens. |
3(0,0,0,3) | Details |
| 7664789 | Oliveira DB, Gillespie K, Wolfreys K, Mathieson PW, Qasim F, Coleman JW: Compounds that induce autoimmunity in the brown Norway rat sensitize mast cells for mediator release and interleukin-4 expression. Eur J Immunol. 1995 Aug;25(8):2259-64. Brown Norway (BN) rats given mercuric chloride (HgCl2), gold (Au) salts or D-penicillamine develop a T helper 2 (Th2) cell-mediated autoimmune syndrome. |
3(0,0,0,3) | Details |
| 7867075 | Prigent P, Poncet P, Aten J, Blanpied C, Chand A, Fevrier M, Druet P, Hirsch F: Mercuric chloride-induced programmed cell death of a murine T cell hybridoma. Cell Immunol. 1995 Mar;161(1):107-11. Opposite effect of interleukin-2 and interleukin-4.. |
3(0,0,0,3) | Details |
| 8658504 | Heo Y, Parsons PJ, Lawrence DA: Lead differentially modifies cytokine production in vitro and in vivo. Toxicol Appl Pharmacol. 1996 May;138(1):149-57. In vitro IL-4 production by a Th2 clone was significantly increased by the addition of PbCl2, whereas IFN gamma production by a Th1 clone was decreased by the addition of PbCl2. |
3(0,0,0,3) | Details |
| 15036746 | Mellergard J, Havarinasab S, Hultman P: Short- and long-term effects of T-cell modulating agents in experimental autoimmunity. Toxicology. 2004 Mar 15;196(3):197-209. However, subsequent treatment with Hg without a-IL-4 for 19 weeks induced IC deposits. |
2(0,0,0,2) | Details |
| 10330268 | Jiang Y, Moller G: IL-2 may be a limiting factor precluding lymphocytes from genetically resistant mice from responding to HgCl2. Int Immunol. 1999 May;11(5):627-33. Unexpectedly, a similar level of IL-4 production was induced in splenocytes from BALB/c and DBA/2 mice. |
2(0,0,0,2) | Details |
| 9376071 | Hu H, Moller G, Abedi-Valugerdi M: Major histocompatibility complex class II antigens are required for both cytokine production and proliferation induced by mercuric chloride in vitro. J Autoimmun. 1997 Oct;10(5):441-6. We also found that the continuous presence of mercury induced IL-2 and IFN-gamma production, while pretreatment with mercury induced IL-4 production. |
2(0,0,0,2) | Details |
| 10447925 | Szeto C, Gillespie KM, Mathieson PW: Low-dose mercuric chloride induces resistance in brown norway rats to further mercuric chloride by up-regulation of interferon-gamma. Scand J Immunol. 1999 Aug;50(2):195-201. Serum IgE and splenic IL-4 mRNA expression remained static when these rats were rechallenged, confirming resistance. |
2(0,0,0,2) | Details |
| 9766631 | Roos A, Schilder-Tol EJ, Weening JJ, Aten J: Strong expression of CD134 (OX40), a member of the TNF receptor family, in a T helper 2-type cytokine environment. J Leukoc Biol. 1998 Oct;64(4):503-10. Effects of interleukin-4 and of phorbol 12- 13- on CD134 expression could be blocked by the protein kinase inhibitor staurosporin. |
2(0,0,0,2) | Details |
| 9469417 | Bagenstose LM, Salgame P, Monestier M: IL-12 down-regulates autoantibody production in mercury-induced autoimmunity. J Immunol. 1998 Feb 15;160(4):1612-7. In genetically susceptible H-2s mice, subtoxic doses of mercuric chloride (HgCl2) induce a complex autoimmune syndrome characterized by the production of anti-nucleolar IgG Abs, lymphoproliferation, increased serum levels of IgG1 and IgE Abs, and renal Ig deposits. The increase in serum IgG1 and IgE, which are under IL-4 control, suggests a role for the Th2 subset in this syndrome. |
2(0,0,0,2) | Details |
| 8666905 | Biancone L, Andres G, Ahn H, Lim A, Dai C, Noelle R, Yagita H, De Martino C, Stamenkovic I: Distinct regulatory roles of lymphocyte costimulatory pathways on T helper type-2 mediated autoimmune disease. J Exp Med. 1996 Apr 1;183(4):1473-81. Inhibition of CD40-CD40-L and CTLA4/CD28-B7s interactions by anti-CD40-L antibody and soluble CTLA4-immunoglobulin (Ig) fusion protein, respectively, abrogated the autoimmune disease without affecting interleukin 4 (IL-4) production, showing the importance of physical contact between T and B lymphocytes in the Th2-mediated process. |
2(0,0,0,2) | Details |
| 11485386 | Strenzke N, Grabbe J, Plath KE, Rohwer J, Wolff HH, Gibbs BF: Mercuric chloride enhances immunoglobulin E-dependent mediator release from human basophils. Toxicol Appl Pharmacol. 2001 Aug 1;174(3):257-63. In rodents, the immunomodulatory effects of HgCl2 have been shown to involve the enhancement of mast cell-derived IL-4 secretion, which facilitates both Th2-lymphocyte development and IgE production. |
2(0,0,0,2) | Details |
| 18432732 | Badou A, Saoudi A, Dietrich G, Druet E, Druet P, Pelletier L: Mercuric chloride-induced autoimmunity. Curr Protoc Immunol. 2001 May;Chapter 15:Unit 15.15. IL-4 is produced very early after the first HgCl (2) injection (beginning at day 3, peaking at day 14, and continuing up to day 30). |
2(0,0,0,2) | Details |
| 12848997 | Fournie GJ, Saoudi A, Druet P, Pelletier L: Th2-type immunopathological manifestations induced by mercury or gold salts in the rat: signal transduction pathways, cellular mechanisms and genetic control. Autoimmun Rev. 2002 Aug;1(4):205-12. Hg or Au act on the early steps of T cell activation resulting in IL-4 and IFNgamma gene expression with preferential IL-4 expression in BN rats. |
2(0,0,0,2) | Details |
| 9022032 | Wolfreys K, Oliveira DB: Alterations in intracellular reactive species generation and redox potential modulate mast cell function. Eur J Immunol. 1997 Jan;27(1):297-306. The administration of mercuric chloride (HgCl2), gold compounds, or D-penicillamine to Brown Norway (BN) rats causes a T helper (Th) 2 cell-associated autoimmune syndrome characterized by the production of a number of autoantibodies, marked elevation of serum IgE concentration, and tissue injury in the form of a vasculitis and arthritis. We have recently shown that the same compounds in vitro sensitize BN rat peritoneal mast cells for IgE-triggered mediator release and interleukin-4 mRNA production. |
1(0,0,0,1) | Details |
| 11844613 | Tuschl H, Landsteiner HT, Kovac R: Application of the popliteal lymph node assay in immunotoxicity testing: complementation of the direct popliteal lymph node assay with flow cytometric analyses. Toxicology. 2002 Mar 5;172(1):35-48. In the present investigation the direct PLNA was extended with the flow cytometric determinations of: (a) lymphoblasts; (b) the phenotyping of lymphoid subpopulations; (c) the determination of expression of proliferation/activation markers CD25, CD69 and CD62L/CD44 and (d) the analysis of intracellular cytokines interferon gamma, interleukin 2 and interleukin 4. |
1(0,0,0,1) | Details |
| 8258322 | Saoudi A, Kuhn J, Huygen K, de Kozak Y, Velu T, Goldman M, Druet P, Bellon B: TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease. Eur J Immunol. 1993 Dec;23(12):3096-103. Mercuric chloride (HgCl2) injections protect Brown-Norway) F1 (F1) rats against experimental autoimmune uveoretinitis (EAU) induced by immunization with the retinal S antigen (S-Ag); in contrast HgCl2-injected F1 rats develop EAU following transfer of lymph node (LN) cells from rats immunized with S-Ag alone. In contrast, LN cells from diseased rats easily transferred EAU into naive F1 rats, produced significant IL-2 and IFN-gamma levels but barely exhibited mRNA for IL-4. |
1(0,0,0,1) | Details |
| 9237798 | Johansson U, Sander B, Hultman P: Effects of the murine genotype on T cell activation and cytokine production in murine mercury-induced autoimmunity. J Autoimmun. 1997 Aug;10(4):347-55. Mice of the susceptible A.SW strain showed a modest increase of TNF-alpha-, IFN-gamma-, and IL-4-producing cells after 4-6 days, and a very distinct increase of IL-4-producing cells on days 8-10. |
2(0,0,0,2) | Details |
| 7637329 | Kiely PD, Thiru S, Oliveira DB: Inflammatory polyarthritis induced by mercuric chloride in the Brown Norway rat. Lab Invest. 1995 Aug;73(2):284-93. The high total IgE levels and evidence showing ex vivo down-regulation of IFN gamma and in vivo up-regulation of IL-4 suggest that HgCl2-induced autoimmunity occurs in a Th2 lymphokine environment. |
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