| Name | interferon gamma |
|---|---|
| Synonyms | IFG; IFI; IFN gamma; IFNG; IFNgamma; Immune interferon; Interferon gamma; Interferon gamma precursor… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15720444 | Hansson M, Djerbi M, Rabbani H, Mellstedt H, Gharibdoost F, Hassan M, Depierre JW, Abedi-Valugerdi M: Exposure to mercuric chloride during the induction phase and after the onset of collagen-induced arthritis enhances immune/autoimmune responses and exacerbates the disease in DBA/1 mice. Immunology. 2005 Mar;114(3):428-37. Furthermore, while animals injected with mercury alone exhibited a significant decrease in the ratio of the levels of interferon-gamma (IFN-gamma) to interleukin-4 (IL-4) mRNA in their spleens, this ratio was increased in mice with CIA, with or without administration of mercury. |
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| 7586682 | Coers W, Vos JT, Van der Meide PH, Van der Horst ML, Huitema S, Weening JJ: Interferon-gamma (IFN-gamma) and IL-4 expressed during mercury-induced membranous nephropathy are toxic for cultured podocytes. Clin Exp Immunol. 1995 Nov;102(2):297-307. |
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| 8427819 | Nordlind K, Liden S: In vitro lymphocyte reactivity to heavy metal salts in the diagnosis of oral mucosal hypersensitivity to amalgam restorations. Br J Dermatol. 1993 Jan;128(1):38-41. Heavy metal salts were added to lymphocyte cultures, and lymphocyte proliferation and levels of IL-2 receptors and interferon-gamma (IFN-gamma) were determined. After addition of mercuric chloride, a statistically significant increase of IFN-gamma was seen in the patient group, indicating a higher reactivity to this metal salt. |
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| 8898950 | Gillespie KM, Saoudi A, Kuhn J, Whittle CJ, Druet P, Bellon B, Mathieson PW: Th1/Th2 cytokine gene expression after mercuric chloride in susceptible and resistant rat strains. Eur J Immunol. 1996 Oct;26(10):2388-92. Involvement of the reciprocal Th1 subset, producing interferon-gamma (IFN-gamma), in resistance of LEW rats to HgCl2 has been suggested. |
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| 11334498 | Fournie GJ, Mas M, Cautain B, Savignac M, Subra JF, Pelletier L, Saoudi A, Lagrange D, Calise M, Druet P: Induction of autoimmunity through bystander effects. J Autoimmun. 2001 May;16(3):319-26. In vitro, both activate signal transduction pathways that result in the expression of cytokines, particularly of IL-4 and IFNgamma. |
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| 10886398 | Szeto C, Gillespie KM, Mathieson PW: Levamisole induces interleukin-18 and shifts type 1/type 2 cytokine balance. Immunology. 2000 Jun;100(2):217-24. Immune responses can be classified, according to the predominant cytokines involved, into type 1 (featuring interferon-gamma, IFN-gamma) and type 2 (featuring interleukin-4, IL-4); imbalance between type 1 and type 2 cytokine compartments has been implicated in many human diseases. Further, the type 2 response induced in BN rats by mercuric chloride was markedly attenuated when rats were pretreated with levamisole: there was a 2-log reduction in maximum serum IgE level and marked attenuation of IL-4 gene upregulation. |
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| 19203382 | Inman RD, Chiu B: Heavy metal exposure reverses genetic resistance to Chlamydia-induced arthritis. Arthritis Res Ther. 2009;11(1):R19. Epub 2009 Feb 9. In the present study, we examine an environmental toxin, mercuric chloride (HgCl2), as a modulator of this innate resistance to arthritis. The local cytokine profile in the joint was markedly altered after mercury exposure, with a suppression of tumour necrosis factor-alpha and interferon-gamma but an enhancement of vascular endothelial growth factor. |
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| 11844613 | Tuschl H, Landsteiner HT, Kovac R: Application of the popliteal lymph node assay in immunotoxicity testing: complementation of the direct popliteal lymph node assay with flow cytometric analyses. Toxicology. 2002 Mar 5;172(1):35-48. In the present investigation the direct PLNA was extended with the flow cytometric determinations of: (a) lymphoblasts; (b) the phenotyping of lymphoid subpopulations; (c) the determination of expression of proliferation/activation markers CD25, CD69 and CD62L/CD44 and (d) the analysis of intracellular cytokines interferon gamma, interleukin 2 and interleukin 4. |
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| 15588918 | Ringerike T, Ulleras E, Volker R, Verlaan B, Eikeset A, Trzaska D, Adamczewska V, Olszewski M, Walczak-Drzewiecka A, Arkusz J, van Loveren H, Nilsson G, Lovik M, Dastych J, Vandebriel RJ: Detection of immunotoxicity using T-cell based cytokine reporter cell lines ("Cell Chip"). Toxicology. 2005 Jan 15;206(2):257-72. We used this prototype "Cell Chip" to test, by means of flow cytometry, the immunomodulatory potential of 13 substances and were able to detect changes in cytokine expression in 12 cases (successful for cyclosporine, rapamycin, pentamidine, thalidomide, bis (tri-n-butyltin) oxide, house dust mite allergen (Der p I), 1-chloro-2,4-dinitrobenzene, tolylene 2,4-diisocyanate, tetrachloroplatinate, and mercuric chloride; unsuccessful for penicillin G). The T-cell lymphoma cell line EL-4 was transfected with the regulatory sequences of interleukin (IL)-2, IL-4, IL-10, interferon (IFN)-gamma or actin fused to the gene for enhanced green fluorescent protein (EGFP) in either a stabile or a destabilised form. |
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| 8918574 | Kiely PD, O'Brien D, Oliveira DB: Anti-CD8 treatment reduces the severity of inflammatory arthritis, but not vasculitis, in mercuric chloride-induced autoimmunity. Clin Exp Immunol. 1996 Nov;106(2):280-5. OX8 treatment also exacerbated the early rise in HgCl2-induced IgE and induced a significant rise in plasma interferon-gamma (IFN-gamma), suggesting that CD8+ cells may have a regulatory influence on Th cell populations. |
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| 8478610 | Mathieson PW, Thiru S, Oliveira DB: Regulatory role of OX22high T cells in mercury-induced autoimmunity in the brown Norway rat. J Exp Med. 1993 May 1;177(5):1309-16. The monoclonal antibody OX22 defines a functional split within CD4+ T cells in the rat, with OX22high cells mainly producing interleukin 2 (IL-2) and interferon gamma and responsible for delayed-type hypersensitivity responses, and OX22low cells mainly producing IL-4 and -5 and responsible for providing B cell help. We have used OX22 in vivo to define the role of these subsets in mercuric chloride-induced autoimmunity in the Brown Norway rat. |
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| 15032693 | Wu Z, MacPhee IA, Oliveira DB: Reactive species in the initiation of IL-4 driven autoimmunity as a potential therapeutic target. Curr Pharm Des. 2004;10(8):899-913. Cells primarily secreting interleukin-2 (IL-2) and interferon-gamma are known as Th1 cells and mediate classical cell-mediated immune responses such as delayed-type hypersensitivity. Study of an animal model of Th2-driven autoimmunity (mercuric chloride-induced autoimmunity in Brown Norway rats) has yielded insights into a possible role for oxidant stress in the generation of Th-2 driven autoimmune responses. |
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| 10478962 | Loftenius A, Skoglund A, Ekstrand J, Hovmark A, Moller E: No evidence for specific in vitro lymphocyte reactivity to HgCl2 in patients with dental amalgam-related contact lesions. J Oral Pathol Med. 1999 Sep;28(8):364-70. The release of interferon-gamma (IFN-gamma) was measured in cell supernatants. |
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| 10886234 | Gorrie MJ, Qasim FJ, Whittle CJ, Gillespie KM, Szeto CC, Nicoletti F, Bolton EM, Bradley JA, Mathieson PW: Exogenous type-1 cytokines modulate mercury-induced hyper-IgE in the rat. Clin Exp Immunol. 2000 Jul;121(1):17-22. In susceptible rat strains, mercuric chloride (HgCl2) induces activation of Th2 cells, with enhanced expression of IL-4, polyclonal B cell activation and very high levels of circulating IgE. We have previously shown that spontaneous regulation of this response coincides with enhanced expression of Th1/type-1 cytokines, including interferon-gamma (IFN-gamma) and IL-12. |
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| 12848997 | Fournie GJ, Saoudi A, Druet P, Pelletier L: Th2-type immunopathological manifestations induced by mercury or gold salts in the rat: signal transduction pathways, cellular mechanisms and genetic control. Autoimmun Rev. 2002 Aug;1(4):205-12. Hg or Au act on the early steps of T cell activation resulting in IL-4 and IFNgamma gene expression with preferential IL-4 expression in BN rats. |
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| 20049214 | Gardner RM, Nyland JF, Evans SL, Wang SB, Doyle KM, Crainiceanu CM, Silbergeld EK: Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro. Environ Health Perspect. 2009 Dec;117(12):1932-8. Epub 2009 Aug 19. IL-4, IL-17, and interferon-gamma increased in a concentration-response manner. PBMCs were cultured with lipopolysaccharide and concentrations of mercuric chloride (HgCl (2)) up to 200 nM. |
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| 14599845 | Field AC, Bloch MF, Bellon B: Neonatal tolerance to a Th2-mediated autoimmune disease generates CD8+ Tc1 regulatory cells. J Autoimmun. 2003 Nov;21(3):201-12. Upon mercury recall, CD8+ CD45RC (high) T cells, that represent the Tc1 subset in the rat, expanded and were polarized towards IFNgamma production. |
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| 8958063 | Hodson D, Oliveira DB: The strain difference in the effect of mercuric chloride on antigen-triggered release from rat mast cells is not mediated via interferon-gamma. Immunology. 1996 Nov;89(3):463-7. |
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| 9135547 | Hu H, Abedi-Valugerdi M, Moller G: Pretreatment of lymphocytes with mercury in vitro induces a response in T cells from genetically determined low-responders and a shift of the interleukin profile. Immunology. 1997 Feb;90(2):198-204. We found that in vitro mercuric chloride induced a high proliferative response in spleen lymphocytes from mercury-susceptible SJL mice, but a low response in resistant mice, such as C57BL/6 (H-2b), A/J (H-2a) and CBA (H-2k) mice. |
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| 8258322 | Saoudi A, Kuhn J, Huygen K, de Kozak Y, Velu T, Goldman M, Druet P, Bellon B: TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease. Eur J Immunol. 1993 Dec;23(12):3096-103. Mercuric chloride (HgCl2) injections protect Brown-Norway) F1 (F1) rats against experimental autoimmune uveoretinitis (EAU) induced by immunization with the retinal S antigen (S-Ag); in contrast HgCl2-injected F1 rats develop EAU following transfer of lymph node (LN) cells from rats immunized with S-Ag alone. |
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| 1825860 | Madrenas J, Parfrey NA, Halloran PF: Interferon gamma-mediated renal MHC expression in mercuric chloride-induced glomerulonephritis. Kidney Int. 1991 Feb;39(2):273-81. |
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| 9218838 | Doth M, Fricke M, Nicoletti F, Garotta G, Van Velthuysen ML, Bruijn JA, Gleichmann E: Genetic differences in immune reactivity to mercuric chloride (HgCl2): immunosuppression of H-2d mice is mediated by interferon-gamma (IFN-gamma). Clin Exp Immunol. 1997 Jul;109(1):149-56. |
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| 10447925 | Szeto C, Gillespie KM, Mathieson PW: Low-dose mercuric chloride induces resistance in brown norway rats to further mercuric chloride by up-regulation of interferon-gamma. Scand J Immunol. 1999 Aug;50(2):195-201. |
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| 8449215 | van der Meide PH, de Labie MC, Botman CA, van Bennekom WP, Olsson T, Aten J, Weening JJ: Mercuric chloride down-regulates T cell interferon-gamma production in brown Norway but not in Lewis rats; role of Eur J Immunol. 1993 Mar;23(3):675-81. Injection of a low dose of mercuric chloride into Brown Norway (BN) rats caused a marked decrease in the concanavalin A (ConA)-induced generation of interferon-gamma-producing cells (IFN-gamma pc) in spleen cell cultures prepared 1 h after mercury administration. |
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| 8305641 | Blake PG, Madrenas J, Halloran PF: Ly-6 in kidney is widely expressed on tubular epithelium and vascular endothelium and is up-regulated by interferon gamma. J Am Soc Nephrol. 1993 Nov;4(5):1140-50. Similar up-regulation of Ly-6 was seen in murine lupus nephritis and in mercuric chloride nephropathy. |
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| 9536116 | Roos A, Schilder-Tol EJ, Chand MA, Claessen N, Lakkis FG, Pascual DW, Weening JJ, Aten J: Differential regulation of expression of the MHC class II molecules RT1.B and RT1.D on rat B lymphocytes: effects of interleukin-4, interleukin-13 and interferon-gamma. Immunology. 1998 Jan;93(1):33-40. Brown Norway (BN) rats exposed to mercuric chloride develop a Th2-dependent systemic autoimmunity, whereas Lewis rats, which are highly susceptible to Th1-mediated autoimmunity, develop immune suppression after mercuric chloride exposure. |
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| 17302730 | Hemdan NY, Lehmann I, Wichmann G, Lehmann J, Emmrich F, Sack U: Immunomodulation by mercuric chloride in vitro: application of different cell activation pathways. Clin Exp Immunol. 2007 May;148(2):325-37. Epub 2007 Feb 14. In MoAb-stimulated cells, interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha and interleukin (IL)-6 production was reduced. |
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