| Name | IL 1 |
|---|---|
| Synonyms | Catabolin; IL 1; IL 1 beta; IL 1B; IL1 beta; IL1B; IL1F2; Interleukin 1… |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11367541 | Pollard KM, Landberg GP: The in vitro proliferation of murine lymphocytes to mercuric chloride is restricted to mature T cells and is interleukin 1 dependent. Int Immunopharmacol. 2001 Mar;1(3):581-93. |
7(0,0,1,2) | Details |
| 19404869 | Zefferino R, Leone A, Piccaluga S, Cincione R, Ambrosi L: Mercury modulates interplay between IL-1beta, TNF-alpha, and gap junctional intercellular communication in keratinocytes: mitigation by J Immunotoxicol. 2008 Oct;5(4):353-60. |
4(0,0,0,4) | Details |
| 18496552 | Li HH, Hsu YH, Wei CC, Lee PT, Chen WC, Chang MS: Interleukin-20 induced cell death in renal epithelial cells and was associated with acute renal failure. Genes Immun. 2008 Jul;9(5):395-404. Epub 2008 May 22. In hypoxic HK-2 cells, IL-20 and IL-22R1 transcripts increased, and IL-20 upregulated IL-1 beta transcripts. |
2(0,0,0,2) | Details |
| 7852051 | Zdolsek JM, Soder O, Hultman P: Mercury induces in vivo and in vitro secretion of interleukin-1 in mice. Immunopharmacology. 1994 Nov-Dec;28(3):201-8. Macrophages from SJL and DBA mice incubated with mercuric chloride (HgCl2) in vitro for 24-72 h secreted an increased amount of interleukin 1 (IL-1) to the supernatant compared with control-incubated macrophages, as determined by a sensitive thymocyte proliferation assay. |
87(1,1,1,7) | Details |
| 1517533 | Shenker BJ, Rooney C, Vitale L, Shapiro IM: Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. Immunopharmacol Immunotoxicol. 1992;14(3):539-53. Mercury also inhibited the ability of these cells to synthesize and secrete IL-1. |
1(0,0,0,1) | Details |
| 17250768 | Escribese MM, Conde E, Martin A, Saenz-Morales D, Sancho D, Perez de Lema G, Lucio-Cazana J, Sanchez-Madrid F, Garcia-Bermejo ML, Mampaso FM: Therapeutic effect of (at-RA) on an autoimmune nephritis experimental model: role of the VLA-4 integrin. BMC Nephrol. 2007 Jan 24;8:3. At-RA markedly reduced proteinuria as well as the number of cellular infiltrates in the renal interstitium, the levels of TNF-alpha and IL-1beta cytokines and VCAM-1 expression in renal tissue. BACKGROUND: Mercuric chloride (HgCl2) induces an autoimmune nephritis in the Brown Norway (BN) rats characterized by anti-glomerular basement membrane antibodies (anti-GBM Ab) deposition, proteinuria and a severe interstitial nephritis, all evident at day 13 of the disease. |
1(0,0,0,1) | Details |
| 7753862 | Hecker M, Boese M, Schini-Kerth VB, Mulsch A, Busse R: Characterization of the stable -derived relaxing factor released from cytokine-stimulated vascular smooth muscle cells as an NG--- adduct. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4671-5. The nature of an -derived relaxing factor released from vascular smooth muscle cells cultured on microcarrier beads and stimulated for 20 h with interleukin 1 beta was investigated. |
1(0,0,0,1) | Details |
| 20049214 | Gardner RM, Nyland JF, Evans SL, Wang SB, Doyle KM, Crainiceanu CM, Silbergeld EK: Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro. Environ Health Perspect. 2009 Dec;117(12):1932-8. Epub 2009 Aug 19. PBMCs were cultured with lipopolysaccharide and concentrations of mercuric chloride (HgCl (2)) up to 200 nM. RESULTS: We found a consistent increase in the release of the proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha, and concurrent decrease in release of the antiinflammatory cytokines interleukin 1-receptor antagonist (IL-1Ra) and IL-10 in human PBMCs treated with subcytotoxic concentrations of HgCl (2). |
1(0,0,0,1) | Details |