Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name mercuric chloride
CAS

Reference List

PubMed Abstract RScore(About this table)
10494917 Divine KK, Ayala-Fierro F, Barber DS, Carter DE: Glutathione, albumin, cysteine, and cys-gly effects on toxicity and accumulation of mercuric chloride in LLC-PK1 cells. J Toxicol Environ Health A. 1999 Aug 13;57(7):489-505.
8(0,0,1,3) Details
15764288 Kiernan JA: Hexazonium pararosaniline as a fixative for animal tissues. Biotech Histochem. 2004 Oct-Dec;79(5-6):203-10.

Model tissues (solutions, gels or films containing gelatin and/or bovine albumin) responded predictably to well known cross-linking (formaldehyde) or coagulant (mercuric chloride) fixatives.
6(0,0,1,1) Details
1922612 Houser MT, Milner LS: Renal tubular protein handling in experimental renal disease. . Nephron. 1991;58(4):461-5.

The present study evaluated renal lysozyme and albumin handling following renal tubular injury induced by both low- and high-dose mercuric chloride (0.5 and 2.0 mg/kg) and maleic acid (50 and 400 mg/kg), and following glomerular injury induced by puromycin aminonucleoside (5 mg/100 g) or Adriamycin (5 mg/kg).
6(0,0,1,1) Details
8478977 Lachapelle M, Guertin F, Marion M, Fournier M, Denizeau F: Mercuric chloride affects protein secretion in rat primary hepatocyte cultures: a biochemical ultrastructural, and gold immunocytochemical study. J Toxicol Environ Health. 1993 Apr;38(4):343-54.

Albumin metabolism was examined because it is a representative liver-specific function.
4(0,0,0,4) Details
12523958 Gulden M, Morchel S, Seibert H: Serum albumin binding at cytotoxic concentrations of chemicals as determined with a cell proliferation assay. Toxicol Lett. 2003 Feb 3;137(3):159-68.

The aim of the present study was to measure the influence of albumin binding on cytotoxic concentrations of chemicals and to determine binding parameters which can be used for quantitative in vitro-in vivo extrapolations.
At 18 microM BSA fractional binding of most of these compounds was low (<25%) but increased up to > or =90% (hexachlorophene, mercuric chloride, thioridazine, pentachlorophenol) at 600 microM BSA.
3(0,0,0,3) Details
9712749 Gobert AP, Semballa S, Daulouede S, Lesthelle S, Taxile M, Veyret B, Vincendeau P: Murine macrophages use oxygen- and nitric oxide-dependent mechanisms to synthesize S-nitroso-albumin and to kill extracellular trypanosomes. Infect Immun. 1998 Sep;66(9):4068-72.

S nitrosylation was confirmed by the Saville reaction, using mercuric chloride.
2(0,0,0,2) Details
12595158 Farina M, Brandao R, Lara FS, Soares FA, Souza DO, Rocha JB: Mechanisms of the inhibitory effects of selenium and mercury on the activity of delta-aminolevulinate dehydratase from mouse liver, kidney and brain. Toxicol Lett. 2003 Mar 20;139(1):55-66.

The main goal of this study was to investigate the simultaneous in vitro effects of sodium selenite (Se (4+)) and mercuric chloride (Hg (2+)) on the activity of hepatic, renal and cerebral delta-aminolevulinate dehydratase (delta-ALA-D) of adult male mice (Swiss albino).
The oxidation of -SH groups from a dithiol (DTT), a monothiol glutathione (GSH) and a protein (albumin) increased in the presence of Hg (2+).
1(0,0,0,1) Details
11499660 Zweers MM, Douma CE, de Waart DR, Korevaar JC, Krediet RT, Struijk DG: Amphotericin B, mercury chloride and peritoneal transport in rabbits. Clin Nephrol. 2001 Jul;56(1):60-8.


HgCl2 administration due to toxic effects: total protein clearance from 97 to 172 microl/min, p < 0.005, and albumin clearance from 59 to 158 microl/min, p < 0.005.
1(0,0,0,1) Details
8476528 Ghosh N, Bhattacharya S: Acute phase response of rabbit to HgCl2 and CdCl2. Biomed Environ Sci. 1993 Mar;6(1):1-7.


A variety of changes occur in the rabbit under metal stress which include the appearance of the acute phase protein, C-reactive protein in the serum and significant reduction in the serum titres of albumin and acetylcholinesterase.
1(0,0,0,1) Details
1280082 Bernard AM, Collette C, Lauwerys R: Renal effects of in utero exposure to mercuric chloride in rats. Arch Toxicol. 1992;66(7):508-13.

Both mothers and newborns developed a transient renal dysfunction resulting in an increased urinary excretion of beta 2-microglobulin and albumin.
1(0,0,0,1) Details
2058675 Dutczak WJ, Clarkson TW, Ballatori N: Biliary-hepatic recycling of a xenobiotic: gallbladder absorption of methyl mercury. Am J Physiol. 1991 Jun;260(6 Pt 1):G873-80.


When the sulfhydryl-containing compounds L-cysteine, glutathione, and bovine serum albumin (20 microM) were added to the test solution, cysteine increased and albumin decreased absorption of methyl mercury.
1(0,0,0,1) Details
3436100 Savige JA, Lockwood CM: Factors affecting the glomerular protein leak after polyclonal activation in the HgCl2-induced model of anti-GBM disease in the brown Norway rat. Clin Exp Immunol. 1987 Dec;70(3):619-29.


Renal injury as measured by urinary loss of albumin and complement (C3) was also cyclical, being maximal on days 15 and 23-26.
1(0,0,0,1) Details
11164207 Hales CA, Du HK, Volokhov A, Mourfarrej R, Quinn DA: Aquaporin channels may modulate ventilator-induced lung injury. Respir Physiol. 2001 Jan;124(2):159-66.


Evans Blue dye, an albumin marker, increased from a control 37+/-11 to 97+/-41 mg/g wet lung in TV 20 rats (P <0.05).
1(0,0,0,1) Details
16327069 Arabi M, Alaeddini MA: Metal-ion-mediated oxidative stress in the gill homogenate of rainbow trout (Oncorhynchus mykiss): antioxidant potential of manganese, selenium, and albumin. Biol Trace Elem Res. 2005 Winter;108(1-3):155-68.

1(0,0,0,1) Details
8997281 Carlsson O, Nielsen S, Zakaria el-R, Rippe B: In vivo inhibition of transcellular water channels (aquaporin-1) during acute peritoneal dialysis in rats. Am J Physiol. 1996 Dec;271(6 Pt 2):H2254-62.


Dianeal (3.86%) was employed as dialysis fluid, 125I-albumin as an intraperitoneal volume marker, and 51Cr-EDTA (constantly infused intravenously) to assess peritoneal small-solute permeability characteristics.
1(0,0,0,1) Details
9918843 Kinosaki M, Yamaguchi K, Yamashita Y, Uematsu Y, Aihara H, Masunaga H, Morinaga T, Higashio K: A mutant of deleted variant of hepatocyte growth factor (dHGF) with alanine substitution in the N-terminal basic region has higher activity in vivo. Biochem Biophys Res Commun. 1999 Jan 19;254(2):363-7.

Administration of #2 to normal rats significantly increased serum levels of total protein, albumin, free-cholesterol, and HDL-cholesterol and liver weight in a dose-dependent manner.
In addition, #2 reduced mortality of mercuric chloride-administered mice and the effect was stronger than that of dHGF.
1(0,0,0,1) Details
8977204 Mnaimneh S, Geffard M, Veyret B, Vincendeau P: Albumin nitrosylated by activated macrophages possesses antiparasitic effects neutralized by anti-NO-acetylated-cysteine antibodies. J Immunol. 1997 Jan 1;158(1):308-14.


It was completely abolished by mercuric chloride, confirming the presence of an S-NO bond.
0(0,0,0,0) Details
12020603 Seibert H, Morchel S, Gulden M: Factors influencing nominal effective concentrations of chemical compounds in vitro: medium protein concentration. Toxicol In Vitro. 2002 Jun;16(3):289-97.

The fractions bound at 4% albumin varied between 11 and 15% for dextropropoxyphene and potassium cyanide, respectively, and more than 99% for hexachlorophene, pentachlorophenol and mercuric chloride.
40(0,1,2,5) Details
8015651 Thielemans N, Lauwerys R, Bernard A: Competition between albumin and low-molecular-weight proteins for renal tubular uptake in experimental nephropathies. Nephron. 1994;66(4):453-8.

We have examined the urinary excretion of albumin and of 2 low-M (r) proteins, beta 2-microglobulin and cystatin C, in rats treated with toxins affecting primarily the glomerulus (puromycin amino-nucleoside and Adriamycin) or the tubule (mercuric chloride and maleic acid).
9(0,0,1,4) Details