| Name | laminin (protein family or complex) |
|---|---|
| Synonyms | Laminin; Laminins |
| Name | mercuric chloride |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8400622 | Chambers BJ, Klein NW: Role of laminin autoantibodies on the embryo toxicity of sera from mercuric chloride treated brown Norway rats. Reprod Toxicol. 1993 Jul-Aug;7(4):333-41. In order to extend these studies, Brown Norway rats were treated with mercuric chloride, which led to the production of laminin autoantibodies. |
87(1,1,2,2) | Details |
| 7778685 | Aten J, Veninga A, Coers W, Sonnenberg A, Timpl R, Claessen N, van Eendenburg JD, de Heer E, Weening JJ: Autoantibodies to the laminin P1 fragment in HgCl2-induced membranous glomerulopathy. Am J Pathol. 1995 Jun;146(6):1467-80. Exposure to mercuric chloride induces the development of a membranous glomerulopathy with high proteinuria in DZB rats, in which immunoglobulin (Ig) G1 and IgG2a bound in the glomeruli were previously found to react with laminin of the EHS tumor and several unidentified glomerular basement membrane components. |
85(1,1,1,5) | Details |
| 7835975 | Druet E, Guery JC, Ayed K, Guilbert B, Avrameas S, Druet P: Characteristics of polyreactive and monospecific IgG anti-laminin autoantibodies in the rat mercury model. Immunology. 1994 Nov;83(3):489-94. |
6(0,0,0,6) | Details |
| 9570334 | Kosuda LL, Whalen B, Greiner DL, Bigazzi PE: Mercury-induced autoimmunity in Brown Norway rats: kinetics of changes in RT6+ T lymphocytes correlated with IgG isotypes of circulating autoantibodies to laminin 1. Toxicology. 1998 Feb 6;125(2-3):215-31. |
5(0,0,0,5) | Details |
| 2407540 | Guery JC, Druet E, Glotz D, Hirsch F, Mandet C, De Heer E, Druet P: Specificity and cross-reactive idiotypes of anti-glomerular basement membrane autoantibodies in HgCl2-induced autoimmune glomerulonephritis. Eur J Immunol. 1990 Jan;20(1):93-100. Anti-laminin autoantibodies represent the major part of the anti-glomerular basement membrane (GBM) antibodies produced in this model. |
5(0,0,0,5) | Details |
| 11412307 | Dammers PM, Bun JC, Bellon B, Kroese FG, Aten J, Bos NA: Immunoglobulin VH-gene usage of autoantibodies in mercuric chloride-induced membranous glomerulopathy in the rat. Immunology. 2001 Jun;103(2):199-209. Laminin is an important autoantigenic target of the anti-GBM Abs, absorbing approximately 30% of the anti-GBM reactivity. |
3(0,0,0,3) | Details |
| 3621683 | Fukatsu A, Brentjens JR, Killen PD, Kleinman HK, Martin GR, Andres GA: Studies on the formation of glomerular immune deposits in brown Norway rats injected with mercuric chloride. Clin Immunol Immunopathol. 1987 Oct;45(1):35-47. The rats were found to develop circulating anti-laminin, anti-type IV collagen, anti-heparan sulfate proteoglycan, and anti-entactin antibodies. |
3(0,0,0,3) | Details |
| 9550285 | Kosuda LL, Greiner DL, Bigazzi PE: Effects of HgCl2 on the expression of autoimmune responses and disease in diabetes-prone (DP) BB rats. Autoimmunity. 1997;26(3):173-87. Repeated exposure of Brown Norway (BN) rats to relatively low doses of HgCl2 induces autoantibodies to renal antigens (e.g., laminin) and a membranous glomerulonephropathy characterized by proteinuria. |
3(0,0,0,3) | Details |
| 8871763 | Kosuda LL, Hannigan MO, Bigazzi PE, Leif JH, Greiner DL: Thymus atrophy and changes in thymocyte subpopulations of BN rats with mercury-induced renal autoimmune disease. Autoimmunity. 1996;23(2):77-89. Administration of low doses of mercury induces autoantibodies to laminin and autoimmune glomerulonephropathy in BN, MAXX and DZB rats as well as in (BN x LEW) F1 hybrids. |
3(0,0,0,3) | Details |
| 7586682 | Coers W, Vos JT, Van der Meide PH, Van der Horst ML, Huitema S, Weening JJ: Interferon-gamma (IFN-gamma) and IL-4 expressed during mercury-induced membranous nephropathy are toxic for cultured podocytes. Clin Exp Immunol. 1995 Nov;102(2):297-307. The subepithelial immune deposits of Dorus Zadel Black (DZB) rats with mercury-induced membranous nephropathy consist of autoantibodies directed to laminin P1 and of complement. |
2(0,0,0,2) | Details |
| 2519016 | Bigazzi PE, Michaelson JH, Potter NT: Epibodies in autoimmunity: antisera against autoantibodies to the renal glomerular basement membrane react with idiotypes as well as with autoantigens. Autoimmunity. 1989;5(1-2):3-16. The results reported here show that we have experimentally produced xenogeneic anti-idiotypic antibodies to rat autoantibodies specific for the renal GBM and one of its components, laminin. |
2(0,0,0,2) | Details |
| 1688961 | Makker SP, Kanalas JJ: Renal antigens in mercuric chloride induced, anti-GBM autoantibody glomerular disease. Kidney Int. 1990 Jan;37(1):64-71. The second probe was a rat monoclonal antibody to the B subunit of laminin that was obtained from fusion of spleen cells of HgCl2 injected BN rat. |
2(0,0,0,2) | Details |
| 8168152 | Kosuda LL, Greiner DL, Bigazzi PE: Mercury-induced renal autoimmunity in BN--> LEW.1N chimeric rats. Cell Immunol. 1994 Apr 15;155(1):77-94. Repeated exposure to relatively low doses of mercuric chloride causes a variety of autoimmune responses in rats of the Brown Norway (BN) strain. These animals experience a membranous glomerulonephritis, characterized by the production of autoantibodies to renal antigens (e.g., laminin) and proteinuria. |
2(0,0,0,2) | Details |
| 1572095 | Lillevang ST, Rosenkvist J, Andersen CB, Larsen S, Kemp E, Kristensen T: Single and combined effects of the analogue KH1060 and cyclosporin A on mercuric-chloride-induced autoimmune disease in the BN rat. Clin Exp Immunol. 1992 May;88(2):301-6. This compound prevents autoimmune manifestations including proteinuria, serum IgE, and serum anti-laminin antibodies in a dose-dependent manner, as does cyclosporin A (CyA). |
2(0,0,0,2) | Details |
| 8550837 | Delaney CP, Murase N, Chen-Woan M, Fung JJ, Starzl TE, Demetris AJ: Allogeneic hematolymphoid microchimerism and prevention of autoimmune disease in the rat. J Clin Invest. 1996 Jan 1;97(1):217-25. More specifically, IgG anti-laminin autoantibody production was decreased by 40% (P < 0.05), and there was less histopathological tissue injury (P < 0.005), less in vitro autoreactivity (P < 0.05), less of an increase in class II MHC expression on B cells (P < 0.01), and 22% less weight loss (P < 0.01), compared with controls. We therefore examined whether inducing hematolymphoid microchimerism without myeloablation could confer the ability to resist mercuric chloride (HgCl2)-induced autoimmunity. |
1(0,0,0,1) | Details |
| 8021964 | Kosuda LL, Hosseinzadeh H, Greiner DL, Bigazzi PE: Role of RT6+ T lymphocytes in mercury-induced renal autoimmunity: experimental manipulations of "susceptible" and "resistant" rats. J Toxicol Environ Health. 1994 Jul;42(3):303-21. Brown Norway (BN) rats, "susceptible" to the autoimmune effects of mercury, experience a decrease of peripheral RT6.2+ T lymphocytes after the injection of relatively low doses of mercuric chloride. This change coincides with the appearance of circulating autoantibodies to renal antigens (e.g., laminin). |
1(0,0,0,1) | Details |
| 14597222 | Bigazzi PE, Kosuda LL, Hannigan MO, Whalen B, Greiner DL: Lack of graft-versus-host-like pathology in mercury-induced autoimmunity of Brown Norway rats. Clin Immunol. 2003 Nov;109(2):229-37. The repeated administration of mercury to Brown Norway (BN) rats induces the production of autoantibodies to laminin 1 and other autoantigens, accompanied by renal deposition of immunoglobulins and a membranous glomerulonephropathy. |
1(0,0,0,1) | Details |
| 1591888 | Aten J, Veninga A, Bruijn JA, Prins FA, de Heer E, Weening JJ: Antigenic specificities of glomerular-bound autoantibodies in membranous glomerulopathy induced by mercuric chloride. Clin Immunol Immunopathol. 1992 Apr;63(1):89-102. High reactivity to GBM was demonstrated by ELISA and Western blotting, which could be absorbed for 30% by laminin or laminin-associated extracellular matrix components. |
1(0,0,0,1) | Details |
| 18432732 | Badou A, Saoudi A, Dietrich G, Druet E, Druet P, Pelletier L: Mercuric chloride-induced autoimmunity. Curr Protoc Immunol. 2001 May;Chapter 15:Unit 15.15. This unit describes methods for inducing autoimmune disease in Brown Norway rats through HgCl (2) injections as well for assessing parameters that characterize the disease by serum IgE concentration assays, anti-laminin antibody measurement, and renal immunofluorescence studies to detect autoantibodies. |
1(0,0,0,1) | Details |
| 19340551 | Watanabe T, Fujii T, Oya T, Horikawa N, Tabuchi Y, Takahashi Y, Morii M, Takeguchi N, Tsukada K, Sakai H: Involvement of aquaporin-5 in differentiation of human gastric cancer cells. J Physiol Sci. 2009 Mar;59(2):113-22. Epub 2009 Jan 14. The AQP5 expression significantly increased the proportion of differentiated cells with a spindle shape, the activity of alkaline phosphatase, a marker for the intestinal epithelial cell type of cancer cells, and the expression level of laminin, an epithelial cell marker. |
1(0,0,0,1) | Details |
| 2015703 | Rossi F, Bellon B, Vial MC, Druet P, Kazatchkine MD: Beneficial effect of human therapeutic intravenous immunoglobulins (IVIg) in mercuric-chloride-induced autoimmune disease of Brown-Norway rats. Clin Exp Immunol. 1991 Apr;84(1):129-33. |
0(0,0,0,0) | Details |