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Staub RE, Sparks SE, Quistad GB, Casida JE: S-methylation as a bioactivation mechanism for mono- and dithiocarbamate pesticides as aldehyde dehydrogenase inhibitors. Chem Res Toxicol. 1995 Dec;8(8):1063-9.
Metam, methyl isothiocyanate, dazomet, and three metabolites (metam-oxon [MeNHC (O) SH], MeNHC (S) SMe, and MeNHC-(O) SMe) administered ip to mice at 40 mg/kg inhibit low-Km liver mitochondrial aldehyde dehydrogenase and elevate ethanol-dependent blood and brain acetaldehyde levels. |
82(1,1,1,2) |
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