Protein Information

Name GSTT1
Synonyms GST class theta; GST class theta 1; GSTT 1; GSTT1; GSTT1 protein; Glutathione S transferase theta 1; Glutathione transferase T1 1; glutathione S transferase T1…

Compound Information

Name methyl bromide
CAS bromomethane

Reference List

PubMed Abstract RScore(About this table)
8704864 Garnier R, Rambourg-Schepens MO, Muller A, Hallier E: Glutathione transferase activity and formation of macromolecular adducts in two cases of acute methyl bromide poisoning. Occup Environ Med. 1996 Mar;53(3):211-15.

Seven weeks after the accident, blood samples were drawn from both patients, for measurement of glutathione transferase activity in erythrocytes (conjugator status--that is, GSTT1 phenotype) and measurement of binding products of methyl bromide with blood proteins.
87(1,1,2,2) Details
10650922 Thier R, Wiebel FA, Bolt HM: Differential substrate behaviours of ethylene oxide and propylene oxide towards human glutathione transferase theta hGSTT1-1. Arch Toxicol. 1999 Nov;73(8-9):489-92.

This sequence of reactivities of homologous epoxides towards GSTT1-1 contrasts to the sequence observed in homologous alkyl halides (methyl bromide, MBr; ethyl bromide, EtBr; n-propyl bromide, PrBr) where the relative sequence MeBr >> EtBr > PrBr is observed.
9(0,0,1,4) Details
12872524 Thier R, Bruning T, Roos PH, Rihs HP, Golka K, Ko Y, Bolt HM: Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes. Int J Hyg Environ Health. 2003 Jun;206(3):149-71.

Human phenotyping is facilitated by the GST activity towards methyl bromide or ethylene oxide in erythrocytes which is representative of the metabolic GSTT1 competence of the entire organism.
9(0,0,1,4) Details
11305778 Muller M, Voss M, Heise C, Schulz T, Bunger J, Hallier E: High-performance liquid chromatography/fluorescence detection of S-methylglutathione formed by glutathione-S-transferase T1 in vitro. Arch Toxicol. 2001 Feb;74(12):760-7.

The time-, protein-, and substrate-dependences of the enzymatic catalysis with the model substrates methyl bromide (MeBr) and methyl chloride (MeCl) were studied.
3(0,0,0,3) Details