Protein Information

Name cytochrome b
Synonyms COB; CYTB; Cytochrome b; Cytochrome b of complex III; MT CYB; MTCYB; mitochondrially encoded cytochrome b; Cytochrome bs…

Compound Information

Name trifloxystrobin
CAS

Reference List

PubMed Abstract RScore(About this table)
18366066 Roohparvar R, Mehrabi R, Van Nistelrooy JG, Zwiers LH, De Waard MA: The drug transporter MgMfs1 can modulate sensitivity of field strains of the fungal wheat pathogen Mycosphaerella graminicola to the strobilurin fungicide trifloxystrobin. Pest Manag Sci. 2008 Jul;64(7):685-93.

The data presented in this paper indicate that, in addition to the predominant cause of strobilurin resistance, cytochrome b G143A subsititution, MgMfs1 can play a role in sensitivity of field strains of this pathogen to trifloxystrobin.
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18943171 Kim YS, Dixon EW, Vincelli P, Farman ML: Field Resistance to Strobilurin (Q (o) I) Fungicides in Pyricularia grisea Caused by Mutations in the Mitochondrial Cytochrome b Gene. Phytopathology. 2003 Jul;93(7):891-900.

The Pyricularia grisea isolates possessing the G143A substitution were significantly more resistant to azoxystrobin and trifloxystrobin, in vitro, than those having F129L.
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12639047 Avila-Adame C, Koller W: Impact of alternative respiration and target-site mutations on responses of germinating conidia of Magnaporthe grisea to Qo-inhibiting fungicides. Pest Manag Sci. 2003 Mar;59(3):303-9.

In contrast, conidia derived from two QoI-resistant target site mutants were highly resistant to azoxystrobin and trifloxystrobin and fully capable of infecting leaf surfaces protected with 10 microg ml (-1) of azoxystrobin.
Qo-inhibiting fungicides act as respiration inhibitors by binding to the Qo center of cytochrome b.
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18247319 Fernandez-Ortuno D, Tores JA, de Vicente A, Perez-Garcia A: Field resistance to QoI fungicides in Podosphaera fusca is not supported by typical mutations in the mitochondrial cytochrome b gene. Pest Manag Sci. 2008 Jul;64(7):694-702.

BACKGROUND: A single nucleotide polymorphism in the mitochondrial cytochrome b gene confers resistance to strobilurin (QoI) fungicides in phytopathogenic fungi.
Exposure to salicylhydroxamic acid (SHAM), a specific inhibitor of alternative oxidase, in the presence of trifloxystrobin did not have any effect on QoI resistance, ruling out alternative respiration as the mechanism of resistance.
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11561403 Steinfeld U, Sierotzki H, Parisi S, Poirey S, Gisi U: Sensitivity of mitochondrial respiration to different inhibitors in Venturia inaequalis. Pest Manag Sci. 2001 Sep;57(9):787-96.


Cross-resistance was observed among QoIs such as trifloxystrobin, azoxystrobin, famoxadone, strobilurin B and myxothiazol.
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