| Name | 5 lipoxygenase |
|---|---|
| Synonyms | 5 lipoxygenase; 5 LO; 5LPG; ALOX 5; ALOX5; Arachidonate 5 lipoxygenase; Arachidonate 5 lipoxygenase variant; LOG 5… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19481465 | Schuhly W, Hufner A, Pferschy-Wenzig EM, Prettner E, Adams M, Bodensieck A, Kunert O, Oluwemimo A, Haslinger E, Bauer R: Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. Bioorg Med Chem. 2009 Jul 1;17(13):4459-65. Epub 2009 May 18. |
112(1,2,2,2) | Details |
| 19053751 | Koeberle A, Zettl H, Greiner C, Wurglics M, Schubert-Zsilavecz M, Werz O: Pirinixic acid derivatives as novel dual inhibitors of microsomal synthase-1 and 5-lipoxygenase. J Med Chem. 2008 Dec 25;51(24):8068-76. Target-oriented structural modification of 1, particularly alpha substitution with extended n-alkyl or bulky aryl substituents and concomitant replacement of the 2,3- by a biphenyl-4-yl--amino residue, resulted in potent suppression of mPGES-1 and 5-LO activity, exemplified by 2-(4-(biphenyl-4-ylmethylamino)-6-chloropyrimidin-2-ylthio) octanoic acid (7b, IC (50) = 1.3 and 1 microM, respectively). |
85(1,1,1,5) | Details |
| 20120103 | Fraternale D, Giamperi L, Bucchini A, Sestili P, Paolillo M, Ricci D: Prunus spinosa fresh fruit juice: antioxidant activity in cell-free and cellular systems. Nat Prod Commun. 2009 Dec;4(12):1665-70. The antioxidant activity was assessed of fresh juice from Prunus spinosa L. fruit (Rosaceae) growing wild in Urbino (central Italy) by using different cell-free in vitro analytical methods: 5-lipoxygenase test, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging, and radical absorbance capacity (ORAC). |
2(0,0,0,2) | Details |
| 18640257 | Essop AB, van Zyl RL, van Vuuren SF, Mulholland D, Viljoen AM: The in vitro pharmacological activities of 12 South African Hermannia species. J Ethnopharmacol. 2008 Oct 28;119(3):615-9. Epub 2008 Jul 1. In addition, all species exhibited moderate anti-inflammatory activity in the 5-lipoxygenase assay with the exception of H. cuneifolia (IC (50)=15.32 microg/ml). |
1(0,0,0,1) | Details |