| Name | transthyretin |
|---|---|
| Synonyms | ATTR; HsT2651; PALB; Prealbumin; TBPA; TTR; Transthyretin; Transthyretin precursor… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20345174 | Gutleb AC, Cenijn P, Velzen MV, Lie E, Ropstad E, Skaare JU, Malmberg T, Bergman A, Gabrielsen GW, Legler J: In Vitro Assay Shows That PCB Metabolites Completely Saturate Thyroid Hormone Transport Capacity in Blood of Wild Polar Bears (Ursus maritimus). Environ Sci Technol. 2010 Mar 26. Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. |
81(1,1,1,1) | Details |
| 17948976 | Gupta S, Chhibber M, Sinha S, Surolia A: Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates. J Med Chem. 2007 Nov 15;50(23):5589-99. Epub 2007 Oct 19. |
33(0,1,1,3) | Details |
| 20039755 | Ucan-Marin F, Arukwe A, Mortensen AS, Gabrielsen GW, Letcher RJ: Recombinant albumin and transthyretin transport proteins from two gull species and human: chlorinated and brominated contaminant binding and thyroid hormones. Environ Sci Technol. 2010 Jan 1;44(1):497-504. Environmentally relevant concentrations of selected polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) flame retardant congeners and their hydroxylated (OH) and methoxylated (MeO) analogues that can perturb thyroid hormone-dependent processes were comparatively examined with respect to competitive binding with (T (4)) and 3,5,3'- (T (3)) thyroid hormones (THs) on recombinant human and gull albumin and transthyretin transport proteins. |
32(0,1,1,2) | Details |
| 19033396 | Ucan-Marin F, Arukwe A, Mortensen A, Gabrielsen GW, Fox GA, Letcher RJ: Recombinant transthyretin purification and competitive binding with organohalogen compounds in two gull species (Larus argentatus and Larus hyperboreus). Toxicol Sci. 2009 Feb;107(2):440-50. Epub 2008 Nov 25. This indicated that the combination of the more thyroid hormone-like brominated diphenyl ether backbone (relative to the chlorinated biphenyl backbone), and in combination of having an OH-group, results in a more effective competitive ligand on gull TTR relative to both T (3) and T (4). |
2(0,0,0,2) | Details |
| 19589873 | Kato Y, Haraguchi K, Kubota M, Seto Y, Ikushiro S, Sakaki T, Koga N, Yamada S, Degawa M: 4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl-mediated decrease in serum level in mice occurs through increase in accumulation of in the liver. Drug Metab Dispos. 2009 Oct;37(10):2095-102. Epub 2009 Jul 9. 4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl (4-OH-CB187) was selected as a major hydroxylated polychlorinated biphenyl metabolite detected from serum of wildlife and humans and was examined for its effect on level of serum thyroid hormone in mice. Binding levels of [(125) I] T (4) to serum proteins after administration of [(125) I] T (4) were significantly changed in 4-OH-CB187-pretreated mice: a decrease in the level of serum [(125) I] T (4)-transthyretin (TTR) complex and an increase in the binding level of [(125) I] T (4) to serum albumin and binding protein in both strains of mice. |
1(0,0,0,1) | Details |