| Name | CYP17 |
|---|---|
| Synonyms | CPT 7; CPT7; CYP17; CYP17A1; CYPXVII; Cytochrome P450 17A1; Cytochrome p450 XVIIA1; P450 C17… |
| Name | biphenyl |
|---|---|
| CAS | 1,1′-biphenyl |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19211174 | Hille UE, Hu Q, Vock C, Negri M, Bartels M, Muller-Vieira U, Lauterbach T, Hartmann RW: Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and -substituted methyleneimidazolyl biphenyls. Eur J Med Chem. 2009 Jul;44(7):2765-75. Epub 2009 Jan 19. |
8(0,0,0,8) | Details |
| 18674917 | Hu Q, Negri M, Jahn-Hoffmann K, Zhuang Y, Olgen S, Bartels M, Muller-Vieira U, Lauterbach T, Hartmann RW: Synthesis, biological evaluation, and molecular modeling studies of methylene substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge. Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. Epub 2008 Jul 9. |
4(0,0,0,4) | Details |
| 18720339 | Pinto-Bazurco Mendieta MA, Negri M, Hu Q, Hille UE, Jagusch C, Jahn-Hoffmann K, Muller-Vieira U, Schmidt D, Lauterbach T, Hartmann RW: CYP17 inhibitors. Arch Pharm. 2008 Oct;341(10):597-609. |
3(0,0,0,3) | Details |
| 18672868 | Pinto-Bazurco Mendieta MA, Negri M, Jagusch C, Muller-Vieira U, Lauterbach T, Hartmann RW: Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer. J Med Chem. 2008 Aug 28;51(16):5009-18. Epub 2008 Aug 2. |
3(0,0,0,3) | Details |
| 18022659 | Canton RF, Scholten DE, Marsh G, de Jong PC, van den Berg M: Inhibition of human placental aromatase activity by hydroxylated polybrominated diphenyl ethers (OH-PBDEs). Toxicol Appl Pharmacol. 2008 Feb 15;227(1):68-75. Epub 2007 Oct 5. For comparison, some structurally related compounds, a dihydroxylated polybrominated biphenyl, which is a natural product (2,2'-dihyroxy-3,3',5,5'-tetrabromobiphenyl (2,2'-diOH-BB80)) and its non-bromo derivative were also included in the study. Recently, our laboratory focused on the possible effects on steroidogenesis of PBDEs and OH-PBDEs, e.g. in the human adrenocortical carcinoma (H295R) cell line indicating that some OH-PBDEs can significantly influence steroidogenic enzymes like CYP19 (aromatase) and CYP17. |
1(0,0,0,1) | Details |
| 18336853 | Furuta C, Noda S, Li C, Suzuki AK, Taneda S, Watanabe G, Taya K: Nitrophenols isolated from diesel exhaust particles regulate steroidogenic gene expression and steroid synthesis in the human H295R adrenocortical cell line. Toxicol Appl Pharmacol. 2008 May 15;229(1):109-20. Epub 2008 Feb 7. To elucidate the non-receptor mediated effects of PNMC and PNMPP, we investigated the production of the steroid hormones and estradiol-17beta and modulation of nine major enzyme genes involved in the synthesis of steroid hormones (CYP11A, CYP11B1, CYP17, CYP19, 17betaHSD1, 17betaHSD4, CYP21, 3betaHSD2, StAR) in human H295R cells supplied with cAMP. |
1(0,0,0,1) | Details |