Protein Information

Name immunoglobulin (protein family or complex)
Synonyms Immunoglobulin; Immunoglobulins

Compound Information

Name pentachlorophenol
CAS 2,3,4,5,6-pentachlorophenol

Reference List

PubMed Abstract RScore(About this table)
2069434 McConnachie PR, Zahalsky AC: Immunological consequences of exposure to pentachlorophenol. . Arch Environ Health. 1991 Jul-Aug;46(4):249-53.

Evaluation of lymphocyte phenotype frequencies, functional responses, serum immunoglobulin levels, and autoantibodies was completed for 38 individuals (i.e., 10 families) who were exposed to pentachlorophenol (PCP) in manufacturer-treated log houses.
7(0,0,1,2) Details
11256860 Daniel V, Huber W, Bauer K, Suesal C, Mytilineos J, Melk A, Conradt C, Opelz G: Association of elevated blood levels of pentachlorophenol (PCP) with cellular and humoral immunodeficiencies. Arch Environ Health. 2001 Jan-Feb;56(1):77-83.

Lymphocyte subpopulations, in-vitro responses to mitogens, allogeneic stimulator cells, plasma neopterin, cytokines, soluble cytokine receptors, soluble adhesion molecules, and immunoglobulin autoantibodies were determined.
2(0,0,0,2) Details
11266329 Daniel V, Huber W, Bauer K, Suesal C, Conradt C, Opelz G: Associations of blood levels of PCB, HCHS, and HCB with numbers of lymphocyte subpopulations, in vitro lymphocyte response, plasma cytokine levels, and immunoglobulin autoantibodies. Environ Health Perspect. 2001 Feb;109(2):173-8.

Pentachlorophenol (PCP), hexachlorocyclohexane-[alpha], -beta, and -[gamma] (HCH-[alpha], -beta, and -[gamma]), polychlorinated biphenyls (PCBs), and hexachlorobenzene (HCB) are widely distributed industrial chemicals.
2(0,0,0,2) Details
1771635 Lang D, Mueller-Ruchholtz W: Human lymphocyte reactivity after in vitro exposure to technical and analytical grade pentachlorophenol. Toxicology. 1991;70(3):271-82.

The synthesis of immunoglobulins was determined after stimulation with T-dependent (PWM) and T-independent (KlebsM) polyclonal B cell activators.
1(0,0,0,1) Details
7200151 Forsell JH, Shull LR, Kateley JR: Subchronic administration of technical pentachlorophenol to lactating dairy cattle: immunotoxicologic evaluation. J Toxicol Environ Health. 1981 Oct;8(4):543-58.

Several in vitro and in vivo assays were conducted to evaluate lymphocyte functions, including (1) quantitation of serum immunoglobulins G, M, and A; (2) induction of blastogenesis in vitro, using concanavalin A and leukoagglutinin as mitogens; (3) measurement of extent of skin reaction to injected purified protein derivative in BCG-sensitized cattle to evaluate delayed hypersensitivity; and (4) quantitation of antibody formation in response to injected sheep red blood cells.
1(0,0,0,1) Details