Protein Information

Name NA K ATPase
Synonyms (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase…

Compound Information

Name pentachlorophenol
CAS 2,3,4,5,6-pentachlorophenol

Reference List

PubMed Abstract RScore(About this table)
185909 Franke H, Barlow CH, Chance B: Oxygen delivery in perfused rat kidney: NADH fluorescence and renal functional state. Am J Physiol. 1976 Oct;231(4):1082-9.


Changes in steady-state levels of reduced pyridine nucleotide (PN) recorded by continuous monitoring of surface fluorescence were correlated with changes in physiological function of perfused rat kidneys when subjected to anoxia, ischemia, hypothermia, variations in perfusion pressure, inhibition of Na-K ATPase, and uncoupling of oxidative phosphorylation.
1(0,0,0,1) Details
10564537 Carrasquer G, Li M, Yang S, Schwartz M, Dinno MA: Effect of pentachlorophenol (PCP) on frog cornea epithelium. Proc Soc Exp Biol Med. 1999 Nov;222(2):139-44.

Present experiments, using an in vitro preparation, were designed to study whether PCP affected the electrophysiological parameters of the bullfrog cornea epithelium, specifically, the Na+/K+ ATPase pump and the K+ conductance located in the basolateral membrane and the Cl- conductance located in the apical membrane.
1(0,0,0,1) Details
6460116 Lorusso DJ, Miller TL, Deinzer ML: Effect of hydroxychlorodiphenyl ethers (chlorinated pre-and isopredioxins) on erythrocyte membrane adenosinetriphosphatase activity. J Toxicol Environ Health. 1981 Jul-Aug;8(1-2):215-23.

The effect of hydroxychlorodiphenyl ethers (HO-ClX-DPEs; chlorinated pre- and isopredibenzodioxins), contaminants of technical chlorophenol preparations, on human erythrocyte membrane-bound adenosinetriphosphatases (ATPases) has been investigated.
Pure pentachlorophenol (PCP) caused both inhibition of Na+, K+, Mg2+-ATPase and stimulation of Mg2+-ATPase, although each effect required a higher concentration of PCP than was needed for the HO-CL9-DPEs.
1(0,0,0,1) Details
2027344 Jansson K, Jansson V: Induction of mutation in V79 Chinese hamster cells by tetrachlorohydroquinone, a metabolite of pentachlorophenol. Mutat Res. 1991 May;260(1):83-7.

Tetrachlorohydroquinone (TCHQ) and tetrachlorocatechol (TCC), two metabolites of the environmental mutagen and carcinogen pentachlorophenol, were tested without exogenous activation in V79 Chinese hamster cells for the induction of mutation at the hypoxanthine phosphoribosyl transferase (HPRT) locus to 6-thioguanine resistance (TGr) and at the Na/K-ATPase locus to ouabain resistance (OuaR).
31(0,1,1,1) Details