| Name | estrogen receptor |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9171990 | Danzo BJ: Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins. Environ Health Perspect. 1997 Mar;105(3):294-301. Methoxychlor, o,p'-DDT1, pentachlorophenol, and nonylphenol significantly reduced [3H] 17 beta- binding to the estrogen receptor by 10, 60, 20, and 75%, respectively. |
82(1,1,1,2) | Details |
| 19765641 | Li J, Ma M, Wang Z: In vitro profiling of endocrine disrupting effects of phenols. Toxicol In Vitro. 2010 Feb;24(1):201-7. Epub 2009 Sep 16. In this study, the ability of 2-tert-butylphenol, 2-isopropylphenol, 4-tert-octylphenol (4-t-OP), (2,4-DCP), 3,4-dichlorophenol (3,4-DCP), pentachlorophenol (PCP), bisphenols A (BPA), tetrabromobisphenol A (TBBPA), tetrachlorobisphenol A (TCBPA) and 4-phenylphenol to activate estrogen receptor (ER), androgen receptor (AR), progesterone receptor (PR) and -related receptor (ERR) were determined using a set of recombined yeast strains. |
82(1,1,1,2) | Details |
| 16626760 | Lemaire G, Mnif W, Mauvais P, Balaguer P, Rahmani R: Activation of alpha- and beta-estrogen receptors by persistent pesticides in reporter cell lines. Life Sci. 2006 Aug 15;79(12):1160-9. Epub 2006 Mar 27. Antagonistic activities toward hERalpha and hERbeta were shown in three (carbaryl, pentachlorophenol and 2,4,5-trichlorophenoxyacetic acid) and seven (chlordecone, methoxychlor, carbaryl, endosulfan, endrin, dieldrin, aldrin) pesticides, respectively. |
6(0,0,0,6) | Details |
| 15081572 | Jung J, Ishida K, Nishihara T: Anti-estrogenic activity of fifty chemicals evaluated by in vitro assays. Life Sci. 2004 May 7;74(25):3065-74. We examined the anti-estrogenic activity of 50 chemicals by the yeast two-hybrid assay and detected the activity of hexachlorophene, pentachlorophenol, and in that order. These chemicals were also observed to inhibit the transcriptional activity of 17beta- in a reporter gene assay system using MCF-7 cells, estrogen receptor-positive breast cancer cells, and to bind directly to estrogen receptor alpha in a competitive binding assay system, although the order of the activity was slightly different among the 3 assays. |
2(0,0,0,2) | Details |
| 8800639 | Flouriot G, Pakdel F, Ducouret B, Valotaire Y: Influence of xenobiotics on rainbow trout liver estrogen receptor and vitellogenin gene expression. J Mol Endocrinol. 1995 Oct;15(2):143-51. Moreover, pentachlorophenol acts as an antagonist of the induction by of rainbow trout ER and Vg gene expression. |
2(0,0,0,2) | Details |
| 16280211 | Terasaka S, Inoue A, Tanji M, Kiyama R: Expression profiling of -responsive genes in breast cancer cells treated with alkylphenols, chlorinated phenols, parabens, or bis- and benzoylphenols for evaluation of estrogenic activity. Toxicol Lett. 2006 May 25;163(2):130-41. Epub 2005 Nov 8. We examined expression profiles of -responsive genes after treatment with alkylphenols (pC), 4-n-ethylphenol (4EP), 4-n-heptylphenol (4HP), 4-t-octylphenol (4OP) and nonylphenol (NP)), chlorinated phenols (4-chlorophenol (4CP), 4-chloro-3,5-dimethylphenol (CDP), (DCP) and pentachlorophenol (PCP)), parabens (methylparaben (MPB), ethylparaben (EPB) propylparaben (PPB) and butylparaben (BuPB)), or bis- and benzoylphenols (bisphenols A and B and p-hydroxybenzophenone (pHBP)) by means of a DNA microarray assay first to evaluate the estrogenic activity of these chemicals and then to understand the structural basis for the activity. By selecting a set of 120 genes showing greater statistical reliability for a more reliable assay for each of the chemicals was achieved and, for the chemicals for which data were available, the results were consistent with those of previously reported estrogen receptor-binding and yeast two-hybrid assays except for chlorinated and few other phenols. |
1(0,0,0,1) | Details |
| 16571359 | Zhao B, Yang J, Liu Z, Xu Z, Qiu Y, Sheng G: Joint anti-estrogenic effects of PCP and TCDD in primary cultures of juvenile goldfish hepatocytes using vitellogenin as a biomarker. Chemosphere. 2006 Oct;65(3):359-64. Epub 2006 Mar 29. This work evaluated the joint anti-estrogenic effects of pentachlorophenol (PCP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) against 17beta- (E2) in juvenile goldfish (Carassius auratus) hepatocyte cultures. The anti-estrogenic effects of PCP appeared to result primarily from the competitive binding to estrogen receptor. |
1(0,0,0,1) | Details |
| 8954930 | Tran DQ, Klotz DM, Ladlie BL, Ide CF, McLachlan JA, Arnold SF: Inhibition of progesterone receptor activity in yeast by synthetic chemicals. Biochem Biophys Res Commun. 1996 Dec 13;229(2):518-23. Numerous synthetic chemicals have estrogenic activity by interacting with the estrogen receptor. However, the estrogenic chemicals p-nonylphenol and 4-tert-octyphenol, and pentachlorophenol, effectively inhibited the activity of the hPR in yeast. |
1(0,0,0,1) | Details |
| 19303142 | Passos AL, Pinto PI, Power DM, Canario AV: A yeast assay based on the gilthead sea bream (teleost fish) estrogen receptor beta for monitoring mimics. Ecotoxicol Environ Saf. 2009 Jul;72(5):1529-37. Epub 2009 Mar 19. The induction of beta-galactosidase activity was strictly dependent on the presence of seabream (Sparus aurata) betaa estrogen receptor (sbERbetaa) and substances known to have estrogenic activity. 17beta- (E (2)) and diethylstilbestrol (DES), both agonists, were most active and the antagonist tamoxifen (TAM) was 14-fold less active than E (2). Among the chemicals tested bisphenol-A was most active, followed by pentachlorophenol and naphthalene. |
1(0,0,0,1) | Details |