| Name | glutathione transferase |
|---|---|
| Synonyms | GST class mu 2; GST 4; GST4; GSTM; GSTM 2; GSTM2; GSTM2 2; GSTmu3… |
| Name | pentachlorophenol |
|---|---|
| CAS | 2,3,4,5,6-pentachlorophenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16620786 | O'Sullivan SM, McCarthy RM, Vargo MA, Colman RF, Sheehan D: Chemical modification at subunit 1 of rat kidney Alpha class glutathione transferase with 2,3,5,6-tetrachloro- close structural connectivity between conjugation activity and non-substrate ligand binding. Biochem Pharmacol. 2006 May 28;71(11):1629-36. Epub 2006 Apr 18. 2, 3, 5, 6-Tetrachloro-1, 4- (TCBQ) is a metabolite of pentachlorophenol known to react with cysteines of glutathione transferases (GSTs). |
82(1,1,1,2) | Details |
| 19016852 | Allocati N, Federici L, Masulli M, Di Ilio C: Glutathione transferases in bacteria. FEBS J. 2009 Jan;276(1):58-75. In addition to their role in detoxification, bacterial GSTs are also involved in a variety of distinct metabolic processes such as the biotransformation of dichloromethane, the degradation of lignin and atrazine, and the reductive dechlorination of pentachlorophenol. |
2(0,0,0,2) | Details |
| 3469034 | Watabe T, Hiratsuka A, Ogura K: Sulphotransferase-mediated covalent binding of the carcinogen 7,12-dihydroxymethylbenz [a] anthracene to calf thymus DNA and its inhibition by glutathione transferase. Carcinogenesis. 1987 Mar;8(3):445-53. The hydroxysteroid sulphotransferase inhibitor, sulphate, strongly retarded the covalent binding of to DNA as well as the 7-sulphate formation from in the biological system, while pentachlorophenol and dichloronitrophenol showed little effect on these reactions. |
2(0,0,0,2) | Details |
| 3729973 | Stewart FP, Smith AG: Metabolism of the "mixed" cytochrome P-450 inducer hexachlorobenzene by rat liver microsomes. Biochem Pharmacol. 1986 Jul 1;35(13):2163-70. In addition to hydroxylation reactions, evidence was obtained for the conjugation of HCB with catalysed by a microsomal glutathione transferase. Hexachlorobenzene (HCB) was metabolised by phenobarbital-induced liver microsomes from male rats to pentachlorobenzene, pentachlorophenol, tetrachloro-1,2-benzenediol and tetrachloro- (1:88:2:9). |
1(0,0,0,1) | Details |
| 10208882 | Reddy GV, Gold MH: A two-component tetrachlorohydroquinone reductive dehalogenase system from the lignin-degrading basidiomycete Phanerochaete chrysosporium. Biochem Biophys Res Commun. 1999 Apr 21;257(3):901-5. Tetrachloro-1,4- (TClHQ) is an intermediate in the degradation of pentachlorophenol by the lignin-degrading basidiomycete Phanerochaete chrysosporium. This membrane-bound glutathione transferase was specific for GSH as a cosubstrate. |
1(0,0,0,1) | Details |
| 3265913 | Oikari A, Linstrom-Seppa P, Kukkonen J: Subchronic metabolic effects and toxicity of a simulated pulp mill effluent on juvenile lake trout, Salmo trutta m. lacustris. Ecotoxicol Environ Saf. 1988 Dec;16(3):202-18. The greatest total gradient between bile and water CP was 5.2 X 10 (4) for pentachlorophenol. In contrast to PSMO, activities of conjugating enzymes UDP-glucuronosyl and glutathione transferases) were decreased in the liver. |
1(0,0,0,1) | Details |
| 2103323 | Turesky RJ, Bracco-Hammer I, Markovic J, Richli U, Kappeler AM, Welti DH: The contribution of N-oxidation to the metabolism of the food-borne carcinogen 2-amino-3,8-dimethylimidazo [4,5-f] quinoxaline in rat hepatocytes. Chem Res Toxicol. 1990 Nov-Dec;3(6):524-35. However, the binding of HNOH-MeIQx to DNA in hepatocytes was independent of sulfotransferase since inhibitors of this enzyme, 2,6-dichloro- (DCNP) and pentachlorophenol (PCP), did not diminish DNA binding. The nitro derivative of MeIQx, a direct-acting bacterial mutagen, was readily detoxified by glutathione transferase, forming a conjugate where the thiol group of displaced the nitro moiety. |
1(0,0,0,1) | Details |